Comparison of the Efficacy of Atorvastatin and Rosuvastatin in Preventing Atrial Fibrillation after Coronary Artery Bypass Grafting: A Double-blind Randomized Comparative Trial
Background: Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by disorganized atrial activity and subsequent mechanical atrial failure. Postoperative AF is a frequent complication of coronary artery bypass grafting (CABG). Although there is evidence of decreased AF after...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-04-01
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| Series: | Journal of Tehran University Heart Center |
| Subjects: | |
| Online Access: | https://jthc.tums.ac.ir/index.php/jthc/article/view/1584 |
| _version_ | 1797742568410185728 |
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| author | Zahra Samadifar Naser Aslanabadi Babak Kazemi Arbat Ahmad Separham Elnaz Javanshir |
| author_facet | Zahra Samadifar Naser Aslanabadi Babak Kazemi Arbat Ahmad Separham Elnaz Javanshir |
| author_sort | Zahra Samadifar |
| collection | DOAJ |
| description |
Background: Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by disorganized atrial activity and subsequent mechanical atrial failure. Postoperative AF is a frequent complication of coronary artery bypass grafting (CABG). Although there is evidence of decreased AF after CABG with statin usage, information is scarce regarding a direct comparison between atorvastatin and rosuvastatin. The present study was conducted to compare the efficacy of rosuvastatin and atorvastatin in preventing post-CABG AF.
Methods: The present double-blind randomized comparative clinical trial selected CABG candidates with stable ischemic heart disease or acute coronary syndromes. Atorvastatin (40 mg per day) or rosuvastatin (20 mg per day) was prescribed 1 week before surgery, and the outcomes were compared.
Results: Two-hundred patients, 100 cases in each group, completed the study. Twenty-five patients in each group were female, and the mean age was 59.30±8.42 years in the rosuvastatin group and 60.13±9.40 years in the atorvastatin group (P=0.513). The frequency of AF was 31% in the atorvastatin group and 27% in the rosuvastatin group (P=0.534). No significant differences existed between the groups concerning the length of hospital and ICU stay (P=0.333 and P=0.161) and in-hospital and 3-month mortality (P=0.315 and P=0.648). A subgroup analysis of only patients with stable ischemic heart disease could not detect a significant difference between the study groups in any of the investigated outcomes. Our logistic regression analysis showed an association only between age and the incidence of AF after CABG (OR, 1.12; 95% CI, 1.05 to 1.20; P<0.01).
Conclusion: Rosuvastatin and atorvastatin are similar concerning the prevention of post-CABG AF, but there is a need for future well-designed multicenter studies on this topic.
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| first_indexed | 2024-03-12T14:42:33Z |
| format | Article |
| id | doaj.art-f7ca8a4f6c1d4f85ac51088c6decf11b |
| institution | Directory Open Access Journal |
| issn | 1735-8620 2008-2371 |
| language | English |
| last_indexed | 2024-03-12T14:42:33Z |
| publishDate | 2023-04-01 |
| publisher | Tehran University of Medical Sciences |
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| series | Journal of Tehran University Heart Center |
| spelling | doaj.art-f7ca8a4f6c1d4f85ac51088c6decf11b2023-08-16T06:22:49ZengTehran University of Medical SciencesJournal of Tehran University Heart Center1735-86202008-23712023-04-0118210.18502/jthc.v18i2.13321Comparison of the Efficacy of Atorvastatin and Rosuvastatin in Preventing Atrial Fibrillation after Coronary Artery Bypass Grafting: A Double-blind Randomized Comparative TrialZahra Samadifar0Naser Aslanabadi1Babak Kazemi Arbat2Ahmad Separham3Elnaz Javanshir4Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Background: Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by disorganized atrial activity and subsequent mechanical atrial failure. Postoperative AF is a frequent complication of coronary artery bypass grafting (CABG). Although there is evidence of decreased AF after CABG with statin usage, information is scarce regarding a direct comparison between atorvastatin and rosuvastatin. The present study was conducted to compare the efficacy of rosuvastatin and atorvastatin in preventing post-CABG AF. Methods: The present double-blind randomized comparative clinical trial selected CABG candidates with stable ischemic heart disease or acute coronary syndromes. Atorvastatin (40 mg per day) or rosuvastatin (20 mg per day) was prescribed 1 week before surgery, and the outcomes were compared. Results: Two-hundred patients, 100 cases in each group, completed the study. Twenty-five patients in each group were female, and the mean age was 59.30±8.42 years in the rosuvastatin group and 60.13±9.40 years in the atorvastatin group (P=0.513). The frequency of AF was 31% in the atorvastatin group and 27% in the rosuvastatin group (P=0.534). No significant differences existed between the groups concerning the length of hospital and ICU stay (P=0.333 and P=0.161) and in-hospital and 3-month mortality (P=0.315 and P=0.648). A subgroup analysis of only patients with stable ischemic heart disease could not detect a significant difference between the study groups in any of the investigated outcomes. Our logistic regression analysis showed an association only between age and the incidence of AF after CABG (OR, 1.12; 95% CI, 1.05 to 1.20; P<0.01). Conclusion: Rosuvastatin and atorvastatin are similar concerning the prevention of post-CABG AF, but there is a need for future well-designed multicenter studies on this topic. https://jthc.tums.ac.ir/index.php/jthc/article/view/1584Atrial fibrillationCoronary artery bypassRosuvastatin calciumAtorvastatin |
| spellingShingle | Zahra Samadifar Naser Aslanabadi Babak Kazemi Arbat Ahmad Separham Elnaz Javanshir Comparison of the Efficacy of Atorvastatin and Rosuvastatin in Preventing Atrial Fibrillation after Coronary Artery Bypass Grafting: A Double-blind Randomized Comparative Trial Journal of Tehran University Heart Center Atrial fibrillation Coronary artery bypass Rosuvastatin calcium Atorvastatin |
| title | Comparison of the Efficacy of Atorvastatin and Rosuvastatin in Preventing Atrial Fibrillation after Coronary Artery Bypass Grafting: A Double-blind Randomized Comparative Trial |
| title_full | Comparison of the Efficacy of Atorvastatin and Rosuvastatin in Preventing Atrial Fibrillation after Coronary Artery Bypass Grafting: A Double-blind Randomized Comparative Trial |
| title_fullStr | Comparison of the Efficacy of Atorvastatin and Rosuvastatin in Preventing Atrial Fibrillation after Coronary Artery Bypass Grafting: A Double-blind Randomized Comparative Trial |
| title_full_unstemmed | Comparison of the Efficacy of Atorvastatin and Rosuvastatin in Preventing Atrial Fibrillation after Coronary Artery Bypass Grafting: A Double-blind Randomized Comparative Trial |
| title_short | Comparison of the Efficacy of Atorvastatin and Rosuvastatin in Preventing Atrial Fibrillation after Coronary Artery Bypass Grafting: A Double-blind Randomized Comparative Trial |
| title_sort | comparison of the efficacy of atorvastatin and rosuvastatin in preventing atrial fibrillation after coronary artery bypass grafting a double blind randomized comparative trial |
| topic | Atrial fibrillation Coronary artery bypass Rosuvastatin calcium Atorvastatin |
| url | https://jthc.tums.ac.ir/index.php/jthc/article/view/1584 |
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