Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and gen...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-06-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296211021171 |
| _version_ | 1818907030928228352 |
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| author | Adrian Springer MD Ruben Schleberger MD Florian Oyen PhD Boris A. Hoffmann MD Stephan Willems MD Christian Meyer MD Florian Langer MD Renate B. Schnabel MD, MSc Paulus Kirchhof MD, PhD Reinhard Schneppenheim MD, PhD Marc D. Lemoine MD |
| author_facet | Adrian Springer MD Ruben Schleberger MD Florian Oyen PhD Boris A. Hoffmann MD Stephan Willems MD Christian Meyer MD Florian Langer MD Renate B. Schnabel MD, MSc Paulus Kirchhof MD, PhD Reinhard Schneppenheim MD, PhD Marc D. Lemoine MD |
| author_sort | Adrian Springer MD |
| collection | DOAJ |
| description | Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). Patients with LAT had more clinical conditions predisposing to stroke (mean CHA 2 DS 2 -VASc-score 3.4 ± 1.5 vs. 1.9 ± 1.4; P < 0.001), a higher LA volume (96 ± 32 vs. 76 ± 21 ml, P = 0.002) and lower LA appendage emptying velocity (0.21 ± 0.11vs. 0.43 ± 0.19 m/s, P < 0.001). Prevalence of FVL, FIIV and VWF-V mutations was not different, but in the subgroup of patients <65 years (y) there was a tendency for a higher incidence of VWF-V with a prevalence of 27% (LAT <65 y) vs. 7% (CTR <65 y, P = 0.066). These findings warrant further investigation of the VWF-V as a risk factor for LA thrombogenesis in younger patients. |
| first_indexed | 2024-12-19T21:48:39Z |
| format | Article |
| id | doaj.art-f7cac77b9e9941a2bb15f65199f39012 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-19T21:48:39Z |
| publishDate | 2021-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-f7cac77b9e9941a2bb15f65199f390122022-12-21T20:04:28ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232021-06-012710.1177/10760296211021171Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control StudyAdrian Springer MD0Ruben Schleberger MD1Florian Oyen PhD2Boris A. Hoffmann MD3Stephan Willems MD4Christian Meyer MD5Florian Langer MD6Renate B. Schnabel MD, MSc7Paulus Kirchhof MD, PhD8Reinhard Schneppenheim MD, PhD9Marc D. Lemoine MD10 Asklepios Hospital St. Georg, Hamburg, Germany Department of Cardiology, University Heart and Vascular Center, Hamburg, Germany Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Asklepios Hospital Harburg, Hamburg, Germany DZHK, partner Site Hamburg/Kiel/Lübeck, Germany Division of Cardiology, Cardiac Neuro- and Electrophysiology Research Consortium (cNEP), EVK, Düsseldorf, Germany Department of Oncology and Hematology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany DZHK, partner Site Hamburg/Kiel/Lübeck, Germany Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany DZHK, partner Site Hamburg/Kiel/Lübeck, GermanyLeft atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). Patients with LAT had more clinical conditions predisposing to stroke (mean CHA 2 DS 2 -VASc-score 3.4 ± 1.5 vs. 1.9 ± 1.4; P < 0.001), a higher LA volume (96 ± 32 vs. 76 ± 21 ml, P = 0.002) and lower LA appendage emptying velocity (0.21 ± 0.11vs. 0.43 ± 0.19 m/s, P < 0.001). Prevalence of FVL, FIIV and VWF-V mutations was not different, but in the subgroup of patients <65 years (y) there was a tendency for a higher incidence of VWF-V with a prevalence of 27% (LAT <65 y) vs. 7% (CTR <65 y, P = 0.066). These findings warrant further investigation of the VWF-V as a risk factor for LA thrombogenesis in younger patients.https://doi.org/10.1177/10760296211021171 |
| spellingShingle | Adrian Springer MD Ruben Schleberger MD Florian Oyen PhD Boris A. Hoffmann MD Stephan Willems MD Christian Meyer MD Florian Langer MD Renate B. Schnabel MD, MSc Paulus Kirchhof MD, PhD Reinhard Schneppenheim MD, PhD Marc D. Lemoine MD Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study Clinical and Applied Thrombosis/Hemostasis |
| title | Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study |
| title_full | Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study |
| title_fullStr | Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study |
| title_full_unstemmed | Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study |
| title_short | Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study |
| title_sort | genetic and clinical predictors of left atrial thrombus a single center case control study |
| url | https://doi.org/10.1177/10760296211021171 |
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