DENV-3 precursor membrane (prM) glycoprotein enhances E protein immunogenicity and confers protection against DENV-2 infections in a murine model

DENV-3 precursor membrane (prM) glycoprotein enhances E protein immunogenicity and confers protection against DENV-2 infections in a murine model

To improve a DNA vaccine containing the truncated dengue virus serotype 2 (DENV-2) envelope (E) protein and evaluate the influence of precursor membrane (prM) glycoprotein polymorphism on E protein immunogenicity, two vaccine candidates have been constructed by upstream insertion of the DENV-2 and D...

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Bibliographic Details
Main Authors: Roberto S. Dias, Michelle D. Teixeira, Mariana F. Xisto, John W. O. Prates, Jessica D. Da Silva, Iago O. Mello, Cynthia C. Da Silva, Sérgio O. De Paula
Format: Article
Language:English
Published: Taylor & Francis Group 2021-05-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
dengue
dna vaccines
prm protein
e protein
Online Access:http://dx.doi.org/10.1080/21645515.2020.1826798

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