Roadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in Belgium
Abstract In the field of oncology research, next-generation sequencing has contributed significantly to the discovery of DNA mutations associated with diagnosis and prognosis. It also aids in the development of targeted therapies to specific mutations and the rise of personalized medicine. As part o...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | Archives of Public Health |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13690-018-0295-z |
| _version_ | 1818777504119259136 |
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| author | Els Van Valckenborgh Aline Hébrant Aline Antoniou Wannes Van Hoof Johan Van Bussel Patrick Pauwels Roberto Salgado Waltruda Van Doren Anouk Waeytens Marc Van den Bulcke |
| author_facet | Els Van Valckenborgh Aline Hébrant Aline Antoniou Wannes Van Hoof Johan Van Bussel Patrick Pauwels Roberto Salgado Waltruda Van Doren Anouk Waeytens Marc Van den Bulcke |
| author_sort | Els Van Valckenborgh |
| collection | DOAJ |
| description | Abstract In the field of oncology research, next-generation sequencing has contributed significantly to the discovery of DNA mutations associated with diagnosis and prognosis. It also aids in the development of targeted therapies to specific mutations and the rise of personalized medicine. As part of molecular diagnostics in cancer patients, analysis by next-generation sequencing is becoming part of routine clinical practice. The introduction of this complex technology in a healthcare system comes with multiple challenges and requires a clear action plan. Such an action plan, as outlined in this paper, was developed in Belgium and includes steps in ensuring the quality and indications of NGS testing, installing data registration and tackling ethical issues. A final step is to perform a pilot study to control the access, quality, harmonization and expertise in DNA testing. This action plan can serve as a guide for similar initiatives by other countries to facilitate NGS implementation in clinical practice. |
| first_indexed | 2024-12-18T11:29:52Z |
| format | Article |
| id | doaj.art-f7d4899532524424878c6323dec6dfb5 |
| institution | Directory Open Access Journal |
| issn | 2049-3258 |
| language | English |
| last_indexed | 2024-12-18T11:29:52Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Archives of Public Health |
| spelling | doaj.art-f7d4899532524424878c6323dec6dfb52022-12-21T21:09:37ZengBMCArchives of Public Health2049-32582018-09-017611710.1186/s13690-018-0295-zRoadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in BelgiumEls Van Valckenborgh0Aline Hébrant1Aline Antoniou2Wannes Van Hoof3Johan Van Bussel4Patrick Pauwels5Roberto Salgado6Waltruda Van Doren7Anouk Waeytens8Marc Van den Bulcke9Belgian Cancer Centre, SciensanoBelgian Cancer Centre, SciensanoQuality of Laboratories, SciensanoBelgian Cancer Centre, SciensanoHealthdata.be, SciensanoPathology Department, University Hospital of AntwerpDepartment of Pathology, GZA Hospitals AntwerpHealth Care Department, National Institute for Health and Disability InsuranceHealth Care Department, National Institute for Health and Disability InsuranceBelgian Cancer Centre, SciensanoAbstract In the field of oncology research, next-generation sequencing has contributed significantly to the discovery of DNA mutations associated with diagnosis and prognosis. It also aids in the development of targeted therapies to specific mutations and the rise of personalized medicine. As part of molecular diagnostics in cancer patients, analysis by next-generation sequencing is becoming part of routine clinical practice. The introduction of this complex technology in a healthcare system comes with multiple challenges and requires a clear action plan. Such an action plan, as outlined in this paper, was developed in Belgium and includes steps in ensuring the quality and indications of NGS testing, installing data registration and tackling ethical issues. A final step is to perform a pilot study to control the access, quality, harmonization and expertise in DNA testing. This action plan can serve as a guide for similar initiatives by other countries to facilitate NGS implementation in clinical practice.http://link.springer.com/article/10.1186/s13690-018-0295-zNext-generation sequencingHealth careCancerPersonalized medicine |
| spellingShingle | Els Van Valckenborgh Aline Hébrant Aline Antoniou Wannes Van Hoof Johan Van Bussel Patrick Pauwels Roberto Salgado Waltruda Van Doren Anouk Waeytens Marc Van den Bulcke Roadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in Belgium Archives of Public Health Next-generation sequencing Health care Cancer Personalized medicine |
| title | Roadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in Belgium |
| title_full | Roadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in Belgium |
| title_fullStr | Roadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in Belgium |
| title_full_unstemmed | Roadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in Belgium |
| title_short | Roadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in Belgium |
| title_sort | roadbook for the implementation of next generation sequencing in clinical practice in oncology and hemato oncology in belgium |
| topic | Next-generation sequencing Health care Cancer Personalized medicine |
| url | http://link.springer.com/article/10.1186/s13690-018-0295-z |
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