Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk
Abstract Background Endometrial cancer is the fourth most common cancer in European women. The major risk factors for endometrial cancer are related to the exposure of endometrium to estrogens not opposed to progestogens, that can lead to a chronic endometrial inflammation. Diet may play a role in c...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3754-y |
| _version_ | 1819093193703030784 |
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| author | Fulvio Ricceri Maria Teresa Giraudo Francesca Fasanelli Dario Milanese Veronica Sciannameo Laura Fiorini Carlotta Sacerdote |
| author_facet | Fulvio Ricceri Maria Teresa Giraudo Francesca Fasanelli Dario Milanese Veronica Sciannameo Laura Fiorini Carlotta Sacerdote |
| author_sort | Fulvio Ricceri |
| collection | DOAJ |
| description | Abstract Background Endometrial cancer is the fourth most common cancer in European women. The major risk factors for endometrial cancer are related to the exposure of endometrium to estrogens not opposed to progestogens, that can lead to a chronic endometrial inflammation. Diet may play a role in cancer risk by modulating chronic inflammation. Methods In the framework of a case-control study, we recruited 297 women with newly diagnosed endometrial cancer and 307 controls from Northern Italy. Using logistic regression, we investigated the role of fruit and vegetable intake, adherence to the Mediterranean diet (MD), and the dietary inflammatory index (DII) in endometrial cancer risk. Results Women in the highest quintile of vegetable intake had a statistically significantly lower endometrial cancer risk (adjusted OR 5th quintile vs 1st quintile: 0.34, 95% CI 0.17-0.68). Women with high adherence to the MD had a risk of endometrial cancer that was about half that of women with low adherence to the MD (adjusted OR: 0.51, 95% CI 0.39-0.86). A protective effect was detected for all the lower quintiles of DII, with the highest protective effect seen for the lowest quintile (adjusted OR 5th quintile vs 1st quintile: 3.28, 95% CI 1.30-8.26). Conclusions These results suggest that high vegetable intake, adherence to the MD, and a low DII are related to a lower endometrial cancer risk, with several putative connected biological mechanisms that strengthen the biological plausibility of this association. |
| first_indexed | 2024-12-21T23:07:37Z |
| format | Article |
| id | doaj.art-f7d9959954bf4833a7817ceb5080623f |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-21T23:07:37Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-f7d9959954bf4833a7817ceb5080623f2022-12-21T18:47:08ZengBMCBMC Cancer1471-24072017-11-011711710.1186/s12885-017-3754-yDiet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer riskFulvio Ricceri0Maria Teresa Giraudo1Francesca Fasanelli2Dario Milanese3Veronica Sciannameo4Laura Fiorini5Carlotta Sacerdote6Department of Clinical and Biological Sciences, University of TurinDepartment of Mathematics “Giuseppe Peano”, University of TurinUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and University of TurinDepartment of Mathematics “Giuseppe Peano”, University of TurinUnit of Epidemiology, Regional Health Service ASL TO3Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and University of TurinUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and University of TurinAbstract Background Endometrial cancer is the fourth most common cancer in European women. The major risk factors for endometrial cancer are related to the exposure of endometrium to estrogens not opposed to progestogens, that can lead to a chronic endometrial inflammation. Diet may play a role in cancer risk by modulating chronic inflammation. Methods In the framework of a case-control study, we recruited 297 women with newly diagnosed endometrial cancer and 307 controls from Northern Italy. Using logistic regression, we investigated the role of fruit and vegetable intake, adherence to the Mediterranean diet (MD), and the dietary inflammatory index (DII) in endometrial cancer risk. Results Women in the highest quintile of vegetable intake had a statistically significantly lower endometrial cancer risk (adjusted OR 5th quintile vs 1st quintile: 0.34, 95% CI 0.17-0.68). Women with high adherence to the MD had a risk of endometrial cancer that was about half that of women with low adherence to the MD (adjusted OR: 0.51, 95% CI 0.39-0.86). A protective effect was detected for all the lower quintiles of DII, with the highest protective effect seen for the lowest quintile (adjusted OR 5th quintile vs 1st quintile: 3.28, 95% CI 1.30-8.26). Conclusions These results suggest that high vegetable intake, adherence to the MD, and a low DII are related to a lower endometrial cancer risk, with several putative connected biological mechanisms that strengthen the biological plausibility of this association.http://link.springer.com/article/10.1186/s12885-017-3754-yEndometrial cancerFruits and vegetablesMediterranean dietDietary inflammatory indexCase-control study |
| spellingShingle | Fulvio Ricceri Maria Teresa Giraudo Francesca Fasanelli Dario Milanese Veronica Sciannameo Laura Fiorini Carlotta Sacerdote Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk BMC Cancer Endometrial cancer Fruits and vegetables Mediterranean diet Dietary inflammatory index Case-control study |
| title | Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk |
| title_full | Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk |
| title_fullStr | Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk |
| title_full_unstemmed | Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk |
| title_short | Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk |
| title_sort | diet and endometrial cancer a focus on the role of fruit and vegetable intake mediterranean diet and dietary inflammatory index in the endometrial cancer risk |
| topic | Endometrial cancer Fruits and vegetables Mediterranean diet Dietary inflammatory index Case-control study |
| url | http://link.springer.com/article/10.1186/s12885-017-3754-y |
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