The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect
Gestational diabetes mellitus (GDM) is a growing public health concern that affects many pregnancies globally. The condition is associated with adverse maternal and neonatal outcomes including gestational hypertension, preeclampsia, placental abruption, preterm birth, stillbirth, and fetal growth re...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/11/9/2217 |
| _version_ | 1827725241380503552 |
|---|---|
| author | Stephanie Dias Carmen Pheiffer Sumaiya Adam |
| author_facet | Stephanie Dias Carmen Pheiffer Sumaiya Adam |
| author_sort | Stephanie Dias |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is a growing public health concern that affects many pregnancies globally. The condition is associated with adverse maternal and neonatal outcomes including gestational hypertension, preeclampsia, placental abruption, preterm birth, stillbirth, and fetal growth restriction. In the long-term, mothers and children have an increased risk of developing metabolic diseases such as type 2 diabetes and cardiovascular disease. Accumulating evidence suggest that alterations in the maternal microbiome may play a role in the pathogenesis of GDM and adverse pregnancy outcomes. This review describes changes in the maternal microbiome during the physiological adaptations of pregnancy, GDM and adverse maternal and neonatal outcomes. Findings from this review highlight the importance of understanding the link between the maternal microbiome and GDM. Furthermore, new therapeutic approaches to prevent or better manage GDM are discussed. Further research and clinical trials are necessary to fully realize the therapeutic potential of the maternal microbiome and translate these findings into clinical practice. |
| first_indexed | 2024-03-10T22:27:36Z |
| format | Article |
| id | doaj.art-f7d9f450636242a8bcec11ed06a7c1ed |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T22:27:36Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-f7d9f450636242a8bcec11ed06a7c1ed2023-11-19T12:02:13ZengMDPI AGMicroorganisms2076-26072023-08-01119221710.3390/microorganisms11092217The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and EffectStephanie Dias0Carmen Pheiffer1Sumaiya Adam2Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg, Cape Town 7505, South AfricaBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg, Cape Town 7505, South AfricaDepartment of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0028, South AfricaGestational diabetes mellitus (GDM) is a growing public health concern that affects many pregnancies globally. The condition is associated with adverse maternal and neonatal outcomes including gestational hypertension, preeclampsia, placental abruption, preterm birth, stillbirth, and fetal growth restriction. In the long-term, mothers and children have an increased risk of developing metabolic diseases such as type 2 diabetes and cardiovascular disease. Accumulating evidence suggest that alterations in the maternal microbiome may play a role in the pathogenesis of GDM and adverse pregnancy outcomes. This review describes changes in the maternal microbiome during the physiological adaptations of pregnancy, GDM and adverse maternal and neonatal outcomes. Findings from this review highlight the importance of understanding the link between the maternal microbiome and GDM. Furthermore, new therapeutic approaches to prevent or better manage GDM are discussed. Further research and clinical trials are necessary to fully realize the therapeutic potential of the maternal microbiome and translate these findings into clinical practice.https://www.mdpi.com/2076-2607/11/9/2217gestational diabetes mellitusmaternal microbiomepregnancy complicationsadverse maternal outcomesadverse neonatal outcomes |
| spellingShingle | Stephanie Dias Carmen Pheiffer Sumaiya Adam The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect Microorganisms gestational diabetes mellitus maternal microbiome pregnancy complications adverse maternal outcomes adverse neonatal outcomes |
| title | The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect |
| title_full | The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect |
| title_fullStr | The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect |
| title_full_unstemmed | The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect |
| title_short | The Maternal Microbiome and Gestational Diabetes Mellitus: Cause and Effect |
| title_sort | maternal microbiome and gestational diabetes mellitus cause and effect |
| topic | gestational diabetes mellitus maternal microbiome pregnancy complications adverse maternal outcomes adverse neonatal outcomes |
| url | https://www.mdpi.com/2076-2607/11/9/2217 |
| work_keys_str_mv | AT stephaniedias thematernalmicrobiomeandgestationaldiabetesmellituscauseandeffect AT carmenpheiffer thematernalmicrobiomeandgestationaldiabetesmellituscauseandeffect AT sumaiyaadam thematernalmicrobiomeandgestationaldiabetesmellituscauseandeffect AT stephaniedias maternalmicrobiomeandgestationaldiabetesmellituscauseandeffect AT carmenpheiffer maternalmicrobiomeandgestationaldiabetesmellituscauseandeffect AT sumaiyaadam maternalmicrobiomeandgestationaldiabetesmellituscauseandeffect |