Sex differences in alpha-synucleinopathies: a systematic review
BackgroundPast research indicates a higher prevalence, incidence, and severe clinical manifestations of alpha-synucleinopathies in men, leading to a suggestion of neuroprotective properties of female sex hormones (especially estrogen). The potential pathomechanisms of any such effect on alpha-synucl...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1204104/full |
| _version_ | 1797776415897157632 |
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| author | Kausar Raheel Gemma Deegan Gemma Deegan Irene Di Giulio Irene Di Giulio Diana Cash Diana Cash Diana Cash Katarina Ilic Katarina Ilic Katarina Ilic Valentina Gnoni Valentina Gnoni K. Ray Chaudhuri Panagis Drakatos Panagis Drakatos Rosalyn Moran Ivana Rosenzweig Ivana Rosenzweig |
| author_facet | Kausar Raheel Gemma Deegan Gemma Deegan Irene Di Giulio Irene Di Giulio Diana Cash Diana Cash Diana Cash Katarina Ilic Katarina Ilic Katarina Ilic Valentina Gnoni Valentina Gnoni K. Ray Chaudhuri Panagis Drakatos Panagis Drakatos Rosalyn Moran Ivana Rosenzweig Ivana Rosenzweig |
| author_sort | Kausar Raheel |
| collection | DOAJ |
| description | BackgroundPast research indicates a higher prevalence, incidence, and severe clinical manifestations of alpha-synucleinopathies in men, leading to a suggestion of neuroprotective properties of female sex hormones (especially estrogen). The potential pathomechanisms of any such effect on alpha-synucleinopathies, however, are far from understood. With that aim, we undertook to systematically review, and to critically assess, contemporary evidence on sex and gender differences in alpha-synucleinopathies using a bench-to-bedside approach.MethodsIn this systematic review, studies investigating sex and gender differences in alpha-synucleinopathies (Rapid Eye Movement (REM) Behavior Disorder (RBD), Parkinson’s Disease (PD), Dementia with Lewy Bodies (DLB), Multiple System Atrophy (MSA)) from 2012 to 2022 were identified using electronic database searches of PubMed, Embase and Ovid.ResultsOne hundred sixty-two studies were included; 5 RBD, 6 MSA, 20 DLB and 131 PD studies. Overall, there is conclusive evidence to suggest sex-and gender-specific manifestation in demographics, biomarkers, genetics, clinical features, interventions, and quality of life in alpha-synucleinopathies. Only limited data exists on the effects of distinct sex hormones, with majority of studies concentrating on estrogen and its speculated neuroprotective effects.ConclusionFuture studies disentangling the underlying sex-specific mechanisms of alpha-synucleinopathies are urgently needed in order to enable novel sex-specific therapeutics. |
| first_indexed | 2024-03-12T22:49:38Z |
| format | Article |
| id | doaj.art-f7dacaceacac4f12a9b822587820c4be |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T22:49:38Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f7dacaceacac4f12a9b822587820c4be2023-07-20T17:12:54ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-07-011410.3389/fneur.2023.12041041204104Sex differences in alpha-synucleinopathies: a systematic reviewKausar Raheel0Gemma Deegan1Gemma Deegan2Irene Di Giulio3Irene Di Giulio4Diana Cash5Diana Cash6Diana Cash7Katarina Ilic8Katarina Ilic9Katarina Ilic10Valentina Gnoni11Valentina Gnoni12K. Ray Chaudhuri13Panagis Drakatos14Panagis Drakatos15Rosalyn Moran16Ivana Rosenzweig17Ivana Rosenzweig18Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomBRAIN, Imaging Centre, CNS, King’s College London, London, United KingdomSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomSchool of Basic and Medical Biosciences, Faculty of Life Science and Medicine, King’s College London, London, United KingdomSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomBRAIN, Imaging Centre, CNS, King’s College London, London, United KingdomDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomBRAIN, Imaging Centre, CNS, King’s College London, London, United KingdomDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomCenter for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro, Lecce, ItalyMovement Disorders Unit, King’s College Hospital and Department of Clinical and Basic Neurosciences, Institute of Psychiatry, Psychology and Neuroscience and Parkinson Foundation Centre of Excellence, King’s College London, London, United KingdomSchool of Basic and Medical Biosciences, Faculty of Life Science and Medicine, King’s College London, London, United KingdomSleep Disorders Centre, Guy’s and St Thomas’ NHS Foundation Trust, London, United KingdomDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, United KingdomSleep Disorders Centre, Guy’s and St Thomas’ NHS Foundation Trust, London, United KingdomBackgroundPast research indicates a higher prevalence, incidence, and severe clinical manifestations of alpha-synucleinopathies in men, leading to a suggestion of neuroprotective properties of female sex hormones (especially estrogen). The potential pathomechanisms of any such effect on alpha-synucleinopathies, however, are far from understood. With that aim, we undertook to systematically review, and to critically assess, contemporary evidence on sex and gender differences in alpha-synucleinopathies using a bench-to-bedside approach.MethodsIn this systematic review, studies investigating sex and gender differences in alpha-synucleinopathies (Rapid Eye Movement (REM) Behavior Disorder (RBD), Parkinson’s Disease (PD), Dementia with Lewy Bodies (DLB), Multiple System Atrophy (MSA)) from 2012 to 2022 were identified using electronic database searches of PubMed, Embase and Ovid.ResultsOne hundred sixty-two studies were included; 5 RBD, 6 MSA, 20 DLB and 131 PD studies. Overall, there is conclusive evidence to suggest sex-and gender-specific manifestation in demographics, biomarkers, genetics, clinical features, interventions, and quality of life in alpha-synucleinopathies. Only limited data exists on the effects of distinct sex hormones, with majority of studies concentrating on estrogen and its speculated neuroprotective effects.ConclusionFuture studies disentangling the underlying sex-specific mechanisms of alpha-synucleinopathies are urgently needed in order to enable novel sex-specific therapeutics.https://www.frontiersin.org/articles/10.3389/fneur.2023.1204104/fullalpha-synucleinopathiessex differencesestrogenParkinson’s diseaseDementia with Lewy Bodies |
| spellingShingle | Kausar Raheel Gemma Deegan Gemma Deegan Irene Di Giulio Irene Di Giulio Diana Cash Diana Cash Diana Cash Katarina Ilic Katarina Ilic Katarina Ilic Valentina Gnoni Valentina Gnoni K. Ray Chaudhuri Panagis Drakatos Panagis Drakatos Rosalyn Moran Ivana Rosenzweig Ivana Rosenzweig Sex differences in alpha-synucleinopathies: a systematic review Frontiers in Neurology alpha-synucleinopathies sex differences estrogen Parkinson’s disease Dementia with Lewy Bodies |
| title | Sex differences in alpha-synucleinopathies: a systematic review |
| title_full | Sex differences in alpha-synucleinopathies: a systematic review |
| title_fullStr | Sex differences in alpha-synucleinopathies: a systematic review |
| title_full_unstemmed | Sex differences in alpha-synucleinopathies: a systematic review |
| title_short | Sex differences in alpha-synucleinopathies: a systematic review |
| title_sort | sex differences in alpha synucleinopathies a systematic review |
| topic | alpha-synucleinopathies sex differences estrogen Parkinson’s disease Dementia with Lewy Bodies |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1204104/full |
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