Association between metabolic syndrome and progression in Parkinson's disease
Background: Parkinson's disease (PD) and metabolic syndrome are separate entities that share common underlying pathophysiology. Management strategy for metabolic syndrome is clinically better characterized and finding a positive clinical correlation between the two could lead to a better unders...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Clinical Epidemiology and Global Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398423001963 |
| _version_ | 1827582818405842944 |
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| author | Saloni Sharma David Oakes Shirley Eberly Carlos Singer Lowell Jillian Tanya Simuni |
| author_facet | Saloni Sharma David Oakes Shirley Eberly Carlos Singer Lowell Jillian Tanya Simuni |
| author_sort | Saloni Sharma |
| collection | DOAJ |
| description | Background: Parkinson's disease (PD) and metabolic syndrome are separate entities that share common underlying pathophysiology. Management strategy for metabolic syndrome is clinically better characterized and finding a positive clinical correlation between the two could lead to a better understanding of Parkinson's disease progression and prognosis. Purpose: To explore the relationship between progression in PD and metabolic syndrome to characterize the underlying pathophysiology, which could then impact the clinical management of PD. Methods: Using modified NCEP (National Cholesterol Education Program) ATP III (Adult Treatment Plan) criteria, patients enrolled in STEADY-PD III (Safety, Tolerability, and Efficacy Assessment of Isradipine) were classified into one of three categories of metabolic syndrome and compared on PD progression over a period of 3 years. Results: Participants with metabolic syndrome showed a trend for more progression in terms of PD, as measured by the total Unified Parkinson's Disease Rating Scale (UPDRS), the motor EDL (Experiences of daily living) scores of the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS), and the Montreal Cognitive Assessment (MoCA). A significant trend for decline in MoCA was found in the group with metabolic syndrome (−0.78), compared with those without metabolic syndrome (0.14). Greater decline in MoCA signifies worse outcomes. Conclusion: The results demonstrate a trend in more clinical progression in PD in subjects with metabolic syndrome. However, results are limited by the sample size and the limited laboratory measurements available. We hope this study will encourage larger sample studies to explore this relationship further. |
| first_indexed | 2024-03-08T22:57:06Z |
| format | Article |
| id | doaj.art-f7dd25d65a5844499ee539275a23c4e6 |
| institution | Directory Open Access Journal |
| issn | 2213-3984 |
| language | English |
| last_indexed | 2024-03-08T22:57:06Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Epidemiology and Global Health |
| spelling | doaj.art-f7dd25d65a5844499ee539275a23c4e62023-12-16T06:07:12ZengElsevierClinical Epidemiology and Global Health2213-39842023-11-0124101409Association between metabolic syndrome and progression in Parkinson's diseaseSaloni Sharma0David Oakes1Shirley Eberly2Carlos Singer3Lowell Jillian4Tanya Simuni5University of Rochester, 601 Elmwood Ave, Rochester, NY, 14620, USA; Corresponding author.University of Rochester, 601 Elmwood Ave, Rochester, NY, 14620, USAUniversity of Rochester, 601 Elmwood Ave, Rochester, NY, 14620, USAUniversity of Miami, USAUniversity of Rochester, 601 Elmwood Ave, Rochester, NY, 14620, USANorthwestern University, USABackground: Parkinson's disease (PD) and metabolic syndrome are separate entities that share common underlying pathophysiology. Management strategy for metabolic syndrome is clinically better characterized and finding a positive clinical correlation between the two could lead to a better understanding of Parkinson's disease progression and prognosis. Purpose: To explore the relationship between progression in PD and metabolic syndrome to characterize the underlying pathophysiology, which could then impact the clinical management of PD. Methods: Using modified NCEP (National Cholesterol Education Program) ATP III (Adult Treatment Plan) criteria, patients enrolled in STEADY-PD III (Safety, Tolerability, and Efficacy Assessment of Isradipine) were classified into one of three categories of metabolic syndrome and compared on PD progression over a period of 3 years. Results: Participants with metabolic syndrome showed a trend for more progression in terms of PD, as measured by the total Unified Parkinson's Disease Rating Scale (UPDRS), the motor EDL (Experiences of daily living) scores of the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS), and the Montreal Cognitive Assessment (MoCA). A significant trend for decline in MoCA was found in the group with metabolic syndrome (−0.78), compared with those without metabolic syndrome (0.14). Greater decline in MoCA signifies worse outcomes. Conclusion: The results demonstrate a trend in more clinical progression in PD in subjects with metabolic syndrome. However, results are limited by the sample size and the limited laboratory measurements available. We hope this study will encourage larger sample studies to explore this relationship further.http://www.sciencedirect.com/science/article/pii/S2213398423001963Parkinson's diseaseMetabolic syndromeInflammationBiomarkersGeriatrics |
| spellingShingle | Saloni Sharma David Oakes Shirley Eberly Carlos Singer Lowell Jillian Tanya Simuni Association between metabolic syndrome and progression in Parkinson's disease Clinical Epidemiology and Global Health Parkinson's disease Metabolic syndrome Inflammation Biomarkers Geriatrics |
| title | Association between metabolic syndrome and progression in Parkinson's disease |
| title_full | Association between metabolic syndrome and progression in Parkinson's disease |
| title_fullStr | Association between metabolic syndrome and progression in Parkinson's disease |
| title_full_unstemmed | Association between metabolic syndrome and progression in Parkinson's disease |
| title_short | Association between metabolic syndrome and progression in Parkinson's disease |
| title_sort | association between metabolic syndrome and progression in parkinson s disease |
| topic | Parkinson's disease Metabolic syndrome Inflammation Biomarkers Geriatrics |
| url | http://www.sciencedirect.com/science/article/pii/S2213398423001963 |
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