O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis
Hyperammonemia occurs in liver diseases affecting ureagenesis, and is life-threatening. Here, the authors show that liver UDP-GlcNAc is increased during hyperammonemia, leading to O-GlcNAcylation of the rate-limiting ureagenesis enzyme CPS1, that enhanced ureagenesis and ammonia detoxification. They...
Main Authors: | Leandro R. Soria, Georgios Makris, Alfonso M. D’Alessio, Angela De Angelis, Iolanda Boffa, Veronica M. Pravata, Véronique Rüfenacht, Sergio Attanasio, Edoardo Nusco, Paola Arena, Andrew T. Ferenbach, Debora Paris, Paola Cuomo, Andrea Motta, Matthew Nitzahn, Gerald S. Lipshutz, Ainhoa Martínez-Pizarro, Eva Richard, Lourdes R. Desviat, Johannes Häberle, Daan M. F. van Aalten, Nicola Brunetti-Pierri |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-09-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-32904-x |
Similar Items
-
O-GlcNAcylation: the sweet side of epigenetics
by: Thomas Dupas, et al.
Published: (2023-12-01) -
Role and Function of O-GlcNAcylation in Cancer
by: Jii Bum Lee, et al.
Published: (2021-10-01) -
O-GlcNAcylation in Renal (Patho)Physiology
by: Rodrigo P. Silva-Aguiar, et al.
Published: (2022-09-01) -
Emerging field: O-GlcNAcylation in ferroptosis
by: Hongshuo Zhang, et al.
Published: (2023-05-01) -
Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation
by: Lercher, L, et al.
Published: (2015)