Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults
Background: The cause of obesity is an imbalance between the number of calories taken and the amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the genetic factors that contribute to obesity in addition to environmental factors. Numerous researches have sugg...
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| Format: | Article |
| Language: | English |
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Yayasan Aliansi Cendekiawan Indonesia Thailand
2024-03-01
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| Series: | GHMJ (Global Health Management Journal) |
| Subjects: | |
| Online Access: | http://publications.inschool.id/index.php/ghmj/article/view/967 |
| _version_ | 1827311514561806336 |
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| author | Tiar Masykuroh Pratamawati Angel Angriani Elma Budai Sadji Gara Samara Brajadenta Donny Nauphar |
| author_facet | Tiar Masykuroh Pratamawati Angel Angriani Elma Budai Sadji Gara Samara Brajadenta Donny Nauphar |
| author_sort | Tiar Masykuroh Pratamawati |
| collection | DOAJ |
| description |
Background: The cause of obesity is an imbalance between the number of calories taken and the amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the genetic factors that contribute to obesity in addition to environmental factors. Numerous researches have suggested a connection between the prevalence of obesity and the FTO rs9939609 gene polymorphism
Aims: The purpose of this study is to ascertain how the FTO rs9939609 gene polymorphism relates to the prevalence of adult obesity.
Methods: At the Biomolecular and Genetics Laboratory of the UGJ Faculty of Medicine, an analytical observational study using a case-control design was carried out with 84 participants, 42 subjects in case group, and 42 subjects in control groups. Data were collected utilizing DNA from blood collection, PCR-RFLP for genotyping, and 2.5% electrophoretic gel for visualization. Chi-square was used for data analysis.
Results: Findings showed that there is no link between the FTO rs9939609 polymorphism and the prevalence of obesity (p>0.05, OR=0.710).
Conclusion: In the Indonesian population, the FTO rs9939609 gene polymorphism is not associated with an increased risk of obesity.
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| first_indexed | 2024-04-24T20:21:11Z |
| format | Article |
| id | doaj.art-f7dd7c1471774402b4f464f8d43745ad |
| institution | Directory Open Access Journal |
| issn | 2580-9296 |
| language | English |
| last_indexed | 2024-04-24T20:21:11Z |
| publishDate | 2024-03-01 |
| publisher | Yayasan Aliansi Cendekiawan Indonesia Thailand |
| record_format | Article |
| series | GHMJ (Global Health Management Journal) |
| spelling | doaj.art-f7dd7c1471774402b4f464f8d43745ad2024-03-22T08:09:30ZengYayasan Aliansi Cendekiawan Indonesia ThailandGHMJ (Global Health Management Journal)2580-92962024-03-017110.35898/ghmj-71967Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in AdultsTiar Masykuroh Pratamawati0Angel Angriani Elma Budai Sadji1Gara Samara Brajadenta2Donny Nauphar3Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia.Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia.Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia.Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia. Background: The cause of obesity is an imbalance between the number of calories taken and the amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the genetic factors that contribute to obesity in addition to environmental factors. Numerous researches have suggested a connection between the prevalence of obesity and the FTO rs9939609 gene polymorphism Aims: The purpose of this study is to ascertain how the FTO rs9939609 gene polymorphism relates to the prevalence of adult obesity. Methods: At the Biomolecular and Genetics Laboratory of the UGJ Faculty of Medicine, an analytical observational study using a case-control design was carried out with 84 participants, 42 subjects in case group, and 42 subjects in control groups. Data were collected utilizing DNA from blood collection, PCR-RFLP for genotyping, and 2.5% electrophoretic gel for visualization. Chi-square was used for data analysis. Results: Findings showed that there is no link between the FTO rs9939609 polymorphism and the prevalence of obesity (p>0.05, OR=0.710). Conclusion: In the Indonesian population, the FTO rs9939609 gene polymorphism is not associated with an increased risk of obesity. http://publications.inschool.id/index.php/ghmj/article/view/967FTO polymorphism rs9939609ObesityAdult |
| spellingShingle | Tiar Masykuroh Pratamawati Angel Angriani Elma Budai Sadji Gara Samara Brajadenta Donny Nauphar Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults GHMJ (Global Health Management Journal) FTO polymorphism rs9939609 Obesity Adult |
| title | Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults |
| title_full | Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults |
| title_fullStr | Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults |
| title_full_unstemmed | Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults |
| title_short | Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults |
| title_sort | association of rs9939609 fto gene polymorphism as a risk factor of obesity in adults |
| topic | FTO polymorphism rs9939609 Obesity Adult |
| url | http://publications.inschool.id/index.php/ghmj/article/view/967 |
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