Hypothalamic interaction with reward-related regions during subjective evaluation of foods
The reward system implemented in the midbrain, ventral striatum, orbitofrontal cortex, and ventromedial prefrontal cortex evaluates and compares various types of rewards given to the organisms. It has been suggested that autonomic factors influence reward-related processing via the hypothalamus, but...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922008655 |
| _version_ | 1811295567318351872 |
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| author | Akitoshi Ogawa Takahiro Osada Masaki Tanaka Akimitsu Suda Koji Nakajima Satoshi Oka Koji Kamagata Shigeki Aoki Yasushi Oshima Sakae Tanaka Nobutaka Hattori Seiki Konishi |
| author_facet | Akitoshi Ogawa Takahiro Osada Masaki Tanaka Akimitsu Suda Koji Nakajima Satoshi Oka Koji Kamagata Shigeki Aoki Yasushi Oshima Sakae Tanaka Nobutaka Hattori Seiki Konishi |
| author_sort | Akitoshi Ogawa |
| collection | DOAJ |
| description | The reward system implemented in the midbrain, ventral striatum, orbitofrontal cortex, and ventromedial prefrontal cortex evaluates and compares various types of rewards given to the organisms. It has been suggested that autonomic factors influence reward-related processing via the hypothalamus, but how the hypothalamus modulates the reward system remains elusive. In this functional magnetic resonance imaging study, the hypothalamus was parcellated into individual hypothalamic nuclei performing different autonomic functions using boundary mapping parcellation analyses. The effective interaction during subjective evaluation of foods in a reward task was then investigated between the human hypothalamic nuclei and the reward-related regions. We found significant brain activity decrease in the paraventricular nucleus (PVH) and lateral nucleus in the hypothalamus in food evaluation compared with monetary evaluation. A psychophysiological interaction analysis revealed dual interactions between the PVH and (1) midbrain region and (2) ventromedial prefrontal cortex, with the former correlated with the stronger tendency of participants toward food-seeking. A dynamic causal modeling analysis further revealed unidirectional interactions from the PVH to the midbrain and ventromedial prefrontal cortex. These results suggest that the PVH in the human hypothalamus interacts with the reward-related regions in the cerebral cortex via multiple pathways (i.e., the midbrain pathway and ventromedial prefrontal pathway) to evaluate rewards for subsequent decision-making. |
| first_indexed | 2024-04-13T05:35:22Z |
| format | Article |
| id | doaj.art-f7de1058dc7942ad935dd2a9a381da77 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-13T05:35:22Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-f7de1058dc7942ad935dd2a9a381da772022-12-22T03:00:19ZengElsevierNeuroImage1095-95722022-12-01264119744Hypothalamic interaction with reward-related regions during subjective evaluation of foodsAkitoshi Ogawa0Takahiro Osada1Masaki Tanaka2Akimitsu Suda3Koji Nakajima4Satoshi Oka5Koji Kamagata6Shigeki Aoki7Yasushi Oshima8Sakae Tanaka9Nobutaka Hattori10Seiki Konishi11Department of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Orthopaedic Surgery, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Orthopaedic Surgery, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Orthopaedic Surgery, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Research Institute for Diseases of Old Age, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Sportology Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Advanced Research Institute for Health Science, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Corresponding author at: Department of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.The reward system implemented in the midbrain, ventral striatum, orbitofrontal cortex, and ventromedial prefrontal cortex evaluates and compares various types of rewards given to the organisms. It has been suggested that autonomic factors influence reward-related processing via the hypothalamus, but how the hypothalamus modulates the reward system remains elusive. In this functional magnetic resonance imaging study, the hypothalamus was parcellated into individual hypothalamic nuclei performing different autonomic functions using boundary mapping parcellation analyses. The effective interaction during subjective evaluation of foods in a reward task was then investigated between the human hypothalamic nuclei and the reward-related regions. We found significant brain activity decrease in the paraventricular nucleus (PVH) and lateral nucleus in the hypothalamus in food evaluation compared with monetary evaluation. A psychophysiological interaction analysis revealed dual interactions between the PVH and (1) midbrain region and (2) ventromedial prefrontal cortex, with the former correlated with the stronger tendency of participants toward food-seeking. A dynamic causal modeling analysis further revealed unidirectional interactions from the PVH to the midbrain and ventromedial prefrontal cortex. These results suggest that the PVH in the human hypothalamus interacts with the reward-related regions in the cerebral cortex via multiple pathways (i.e., the midbrain pathway and ventromedial prefrontal pathway) to evaluate rewards for subsequent decision-making.http://www.sciencedirect.com/science/article/pii/S1053811922008655Dynamic causal modelingPsychophysiological interactionSubjective value |
| spellingShingle | Akitoshi Ogawa Takahiro Osada Masaki Tanaka Akimitsu Suda Koji Nakajima Satoshi Oka Koji Kamagata Shigeki Aoki Yasushi Oshima Sakae Tanaka Nobutaka Hattori Seiki Konishi Hypothalamic interaction with reward-related regions during subjective evaluation of foods NeuroImage Dynamic causal modeling Psychophysiological interaction Subjective value |
| title | Hypothalamic interaction with reward-related regions during subjective evaluation of foods |
| title_full | Hypothalamic interaction with reward-related regions during subjective evaluation of foods |
| title_fullStr | Hypothalamic interaction with reward-related regions during subjective evaluation of foods |
| title_full_unstemmed | Hypothalamic interaction with reward-related regions during subjective evaluation of foods |
| title_short | Hypothalamic interaction with reward-related regions during subjective evaluation of foods |
| title_sort | hypothalamic interaction with reward related regions during subjective evaluation of foods |
| topic | Dynamic causal modeling Psychophysiological interaction Subjective value |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922008655 |
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