The leachate from the Urban Solid Waste Transfer Station produces neurotoxicity in Wistar rats
Leachate from municipal solid waste is a mixture of xenobiotics capable of contaminating bodies of water and causing damage to the health of living beings that inhabit or consume contaminated water. A previous study revealed the presence of heavy metals in Urban Solid Waste Transfer Station (USWTS)...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221475002400026X |
| _version_ | 1797262960161193984 |
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| author | Torres-González Omar Ricardo Flores-Soto Mario Eduardo Tejeda-Martínez Aldo Rafael Sánchez-Hernández Iván Moisés Chaparro-Huerta Verónica Soria-Fregozo Cesar González-Garibay Angélica Sofía Padilla-Camberos Eduardo |
| author_facet | Torres-González Omar Ricardo Flores-Soto Mario Eduardo Tejeda-Martínez Aldo Rafael Sánchez-Hernández Iván Moisés Chaparro-Huerta Verónica Soria-Fregozo Cesar González-Garibay Angélica Sofía Padilla-Camberos Eduardo |
| author_sort | Torres-González Omar Ricardo |
| collection | DOAJ |
| description | Leachate from municipal solid waste is a mixture of xenobiotics capable of contaminating bodies of water and causing damage to the health of living beings that inhabit or consume contaminated water. A previous study revealed the presence of heavy metals in Urban Solid Waste Transfer Station (USWTS) leachate above the permissible national and international limits. In the present study, we demonstrate that subchronic oral administration (5 and 25 % v/v) of leachate to male Wistar rats caused changes in the immunoreactivity of the glial markers: GFAP and Iba-1, accompanied by an increase in the expression of caspase-3, and a decrease in the expression of the NeuN protein. Results indicate that the heavy metals present in the leachate induced neuronal loss in the prefrontal cortex, suggesting that these contaminants can cause neurological problems in mammals that consume surface water with xenobiotics, since the leachate could contaminate water bodies and underground water. |
| first_indexed | 2024-04-25T00:05:24Z |
| format | Article |
| id | doaj.art-f7de7f0355ce4dc28cf64e11d48f0222 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-25T00:05:24Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-f7de7f0355ce4dc28cf64e11d48f02222024-03-14T06:14:37ZengElsevierToxicology Reports2214-75002024-06-0112318324The leachate from the Urban Solid Waste Transfer Station produces neurotoxicity in Wistar ratsTorres-González Omar Ricardo0Flores-Soto Mario Eduardo1Tejeda-Martínez Aldo Rafael2Sánchez-Hernández Iván Moisés3Chaparro-Huerta Verónica4Soria-Fregozo Cesar5González-Garibay Angélica Sofía6Padilla-Camberos Eduardo7Unidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ), MexicoDivision de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), MexicoDivision de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), MexicoUnidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ), MexicoDivision de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), MexicoDepartamento de Ciencias de la Tierra y de la Vida, Centro Universitario de los Lagos, Universidad de Guadalajara, MexicoUnidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ), MexicoUnidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ), Mexico; Corresponding author.Leachate from municipal solid waste is a mixture of xenobiotics capable of contaminating bodies of water and causing damage to the health of living beings that inhabit or consume contaminated water. A previous study revealed the presence of heavy metals in Urban Solid Waste Transfer Station (USWTS) leachate above the permissible national and international limits. In the present study, we demonstrate that subchronic oral administration (5 and 25 % v/v) of leachate to male Wistar rats caused changes in the immunoreactivity of the glial markers: GFAP and Iba-1, accompanied by an increase in the expression of caspase-3, and a decrease in the expression of the NeuN protein. Results indicate that the heavy metals present in the leachate induced neuronal loss in the prefrontal cortex, suggesting that these contaminants can cause neurological problems in mammals that consume surface water with xenobiotics, since the leachate could contaminate water bodies and underground water.http://www.sciencedirect.com/science/article/pii/S221475002400026XLeachateLandfillIn vivoNeurotoxicityImmunochemistry |
| spellingShingle | Torres-González Omar Ricardo Flores-Soto Mario Eduardo Tejeda-Martínez Aldo Rafael Sánchez-Hernández Iván Moisés Chaparro-Huerta Verónica Soria-Fregozo Cesar González-Garibay Angélica Sofía Padilla-Camberos Eduardo The leachate from the Urban Solid Waste Transfer Station produces neurotoxicity in Wistar rats Toxicology Reports Leachate Landfill In vivo Neurotoxicity Immunochemistry |
| title | The leachate from the Urban Solid Waste Transfer Station produces neurotoxicity in Wistar rats |
| title_full | The leachate from the Urban Solid Waste Transfer Station produces neurotoxicity in Wistar rats |
| title_fullStr | The leachate from the Urban Solid Waste Transfer Station produces neurotoxicity in Wistar rats |
| title_full_unstemmed | The leachate from the Urban Solid Waste Transfer Station produces neurotoxicity in Wistar rats |
| title_short | The leachate from the Urban Solid Waste Transfer Station produces neurotoxicity in Wistar rats |
| title_sort | leachate from the urban solid waste transfer station produces neurotoxicity in wistar rats |
| topic | Leachate Landfill In vivo Neurotoxicity Immunochemistry |
| url | http://www.sciencedirect.com/science/article/pii/S221475002400026X |
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