Gut bacterial bile salt hydrolase activity correlates with cardiovascular risk: a case-control study
Background. Serum cholesterol may be regulated by bile acid metabolism in the gut that depends on bacterial bile salt hydrolase (BSH) activity. There are limiting data regarding the clear effect of BSH on host lipid metabolism and cardiovascular risk (CVR). The investigation aimed to assess the rela...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2020-10-01
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| Series: | Gastroenterologìa |
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| Online Access: | http://gastro.zaslavsky.com.ua/article/view/216711 |
| _version_ | 1819279569855709184 |
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| author | A. Neverovskyi V. Chernyavskyi V. Shypulin L. Gvozdecka N. Mikhnova |
| author_facet | A. Neverovskyi V. Chernyavskyi V. Shypulin L. Gvozdecka N. Mikhnova |
| author_sort | A. Neverovskyi |
| collection | DOAJ |
| description | Background. Serum cholesterol may be regulated by bile acid metabolism in the gut that depends on bacterial bile salt hydrolase (BSH) activity. There are limiting data regarding the clear effect of BSH on host lipid metabolism and cardiovascular risk (CVR). The investigation aimed to assess the relationship between the gut bacterial BSH relative activity (RA) and serum cholesterol with CVR levels. Materials and methods. The investigation was conducted as a case-control study and included 26 almost healthy participants (a control group) and 77 patients with dyslipidemia and without anamnesis of major cardiovascular events (a case group). The total RA of gut BSH, lipid profile, and CVR level according to 5 risk scores were assessed. Results. The RA of BSH was higher in healthy adults comparing to participants with dyslipidemia (p < 0.001). There were found moderate negative correlation between RA of gut bacterial BSH and total cholesterol (TC) (–0.38) and moderate correlation with low-density lipoproteins (LDL) (–0.36) with linear relationship that is defined by equation: LDL = –5.33 • RA of BSH + 4.479. It was revealed that with increasing of RA of gut bacterial BSH, the risk of dyslipidemia decreased (р < 0.001), OR = 1.06 • 10–10 (95% confidence interval; 2.5 • 10–15 – 4.5 • 10–6). There was found a moderate negative correlation between RA of gut bacterial BSH and CVR levels according to Globorisk score (–0.34), Framingham score (–0.34), 2013 ACC/AHA algorithm (–0.32), PROCAM score (–0.35), and WHO risk chart (–0.34). Conclusions. The total RA of the gut bacterial BSH negatively correlated with TC, LDL, and CVR levels according to 5 risk scores and was negatively associated with the risk of dyslipidemia. |
| first_indexed | 2024-12-24T00:30:00Z |
| format | Article |
| id | doaj.art-f7de9983f3134d4988fea646bdc36dae |
| institution | Directory Open Access Journal |
| issn | 2308-2097 2518-7880 |
| language | English |
| last_indexed | 2024-12-24T00:30:00Z |
| publishDate | 2020-10-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Gastroenterologìa |
| spelling | doaj.art-f7de9983f3134d4988fea646bdc36dae2022-12-21T17:24:17ZengZaslavsky O.Yu.Gastroenterologìa2308-20972518-78802020-10-0154422823310.22141/2308-2097.54.4.2020.216711216711Gut bacterial bile salt hydrolase activity correlates with cardiovascular risk: a case-control studyA. Neverovskyi0V. Chernyavskyi1V. Shypulin2L. Gvozdecka3N. Mikhnova4Bogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineBackground. Serum cholesterol may be regulated by bile acid metabolism in the gut that depends on bacterial bile salt hydrolase (BSH) activity. There are limiting data regarding the clear effect of BSH on host lipid metabolism and cardiovascular risk (CVR). The investigation aimed to assess the relationship between the gut bacterial BSH relative activity (RA) and serum cholesterol with CVR levels. Materials and methods. The investigation was conducted as a case-control study and included 26 almost healthy participants (a control group) and 77 patients with dyslipidemia and without anamnesis of major cardiovascular events (a case group). The total RA of gut BSH, lipid profile, and CVR level according to 5 risk scores were assessed. Results. The RA of BSH was higher in healthy adults comparing to participants with dyslipidemia (p < 0.001). There were found moderate negative correlation between RA of gut bacterial BSH and total cholesterol (TC) (–0.38) and moderate correlation with low-density lipoproteins (LDL) (–0.36) with linear relationship that is defined by equation: LDL = –5.33 • RA of BSH + 4.479. It was revealed that with increasing of RA of gut bacterial BSH, the risk of dyslipidemia decreased (р < 0.001), OR = 1.06 • 10–10 (95% confidence interval; 2.5 • 10–15 – 4.5 • 10–6). There was found a moderate negative correlation between RA of gut bacterial BSH and CVR levels according to Globorisk score (–0.34), Framingham score (–0.34), 2013 ACC/AHA algorithm (–0.32), PROCAM score (–0.35), and WHO risk chart (–0.34). Conclusions. The total RA of the gut bacterial BSH negatively correlated with TC, LDL, and CVR levels according to 5 risk scores and was negatively associated with the risk of dyslipidemia.http://gastro.zaslavsky.com.ua/article/view/216711bile salt hydrolase activitydyslipidemiacardiovascular risk |
| spellingShingle | A. Neverovskyi V. Chernyavskyi V. Shypulin L. Gvozdecka N. Mikhnova Gut bacterial bile salt hydrolase activity correlates with cardiovascular risk: a case-control study Gastroenterologìa bile salt hydrolase activity dyslipidemia cardiovascular risk |
| title | Gut bacterial bile salt hydrolase activity correlates with cardiovascular risk: a case-control study |
| title_full | Gut bacterial bile salt hydrolase activity correlates with cardiovascular risk: a case-control study |
| title_fullStr | Gut bacterial bile salt hydrolase activity correlates with cardiovascular risk: a case-control study |
| title_full_unstemmed | Gut bacterial bile salt hydrolase activity correlates with cardiovascular risk: a case-control study |
| title_short | Gut bacterial bile salt hydrolase activity correlates with cardiovascular risk: a case-control study |
| title_sort | gut bacterial bile salt hydrolase activity correlates with cardiovascular risk a case control study |
| topic | bile salt hydrolase activity dyslipidemia cardiovascular risk |
| url | http://gastro.zaslavsky.com.ua/article/view/216711 |
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