RON is not a prognostic marker for resectable pancreatic cancer
<p>Abstract</p> <p>Background</p> <p>The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognosti...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-09-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2407/12/395 |
| _version_ | 1811251574430760960 |
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| author | Tactacan Carole M Chang David K Cowley Mark J Humphrey Emily S Wu Jianmin Gill Anthony J Chou Angela Nones Katia Grimmond Sean M Sutherland Robert L Biankin Andrew V Daly Roger J |
| author_facet | Tactacan Carole M Chang David K Cowley Mark J Humphrey Emily S Wu Jianmin Gill Anthony J Chou Angela Nones Katia Grimmond Sean M Sutherland Robert L Biankin Andrew V Daly Roger J |
| author_sort | Tactacan Carole M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown.</p> <p>Methods</p> <p>RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed.</p> <p>Results</p> <p>RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study.</p> <p>Conclusions</p> <p>Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.</p> |
| first_indexed | 2024-04-12T16:22:28Z |
| format | Article |
| id | doaj.art-f7e1728bb7404ee3aa7efaa1e2f6b3ff |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T16:22:28Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-f7e1728bb7404ee3aa7efaa1e2f6b3ff2022-12-22T03:25:32ZengBMCBMC Cancer1471-24072012-09-0112139510.1186/1471-2407-12-395RON is not a prognostic marker for resectable pancreatic cancerTactacan Carole MChang David KCowley Mark JHumphrey Emily SWu JianminGill Anthony JChou AngelaNones KatiaGrimmond Sean MSutherland Robert LBiankin Andrew VDaly Roger J<p>Abstract</p> <p>Background</p> <p>The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown.</p> <p>Methods</p> <p>RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed.</p> <p>Results</p> <p>RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study.</p> <p>Conclusions</p> <p>Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.</p>http://www.biomedcentral.com/1471-2407/12/395Receptor tyrosine kinaseBiomarkerGemcitabineChemotherapy |
| spellingShingle | Tactacan Carole M Chang David K Cowley Mark J Humphrey Emily S Wu Jianmin Gill Anthony J Chou Angela Nones Katia Grimmond Sean M Sutherland Robert L Biankin Andrew V Daly Roger J RON is not a prognostic marker for resectable pancreatic cancer BMC Cancer Receptor tyrosine kinase Biomarker Gemcitabine Chemotherapy |
| title | RON is not a prognostic marker for resectable pancreatic cancer |
| title_full | RON is not a prognostic marker for resectable pancreatic cancer |
| title_fullStr | RON is not a prognostic marker for resectable pancreatic cancer |
| title_full_unstemmed | RON is not a prognostic marker for resectable pancreatic cancer |
| title_short | RON is not a prognostic marker for resectable pancreatic cancer |
| title_sort | ron is not a prognostic marker for resectable pancreatic cancer |
| topic | Receptor tyrosine kinase Biomarker Gemcitabine Chemotherapy |
| url | http://www.biomedcentral.com/1471-2407/12/395 |
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