Contributions of Costimulatory Molecule CD137 in Endothelial Cells
Abstract CD137 (4‐1BB, tumor necrosis factor receptor superfamily 9) is a surface glycoprotein of the tumor necrosis factor receptor family that can be induced on a variety of immunocytes and nonimmune cells, including endothelial cells and smooth muscle cells. The importance of CD137 in immune resp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-06-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.120.020721 |
| _version_ | 1811275172096770048 |
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| author | Wei Yuan Chong Xu Bo Li Hao Xia Yingjie Pan Wei Zhong Liangjie Xu Rui Chen Bin Wang |
| author_facet | Wei Yuan Chong Xu Bo Li Hao Xia Yingjie Pan Wei Zhong Liangjie Xu Rui Chen Bin Wang |
| author_sort | Wei Yuan |
| collection | DOAJ |
| description | Abstract CD137 (4‐1BB, tumor necrosis factor receptor superfamily 9) is a surface glycoprotein of the tumor necrosis factor receptor family that can be induced on a variety of immunocytes and nonimmune cells, including endothelial cells and smooth muscle cells. The importance of CD137 in immune response has been well recognized; however, the precise biological effects and underlying mechanisms of CD137 in endothelial cells are unclear. A single layer of cells called the endothelium constitutes the innermost layer of blood vessels including larger arteries, veins, the capillaries, and the lymphatic vessels. It not only acts as an important functional interface, but also participates in local inflammatory response. This review covers recent findings to illuminate the role of CD137 in endothelial cells in different pathophysiologic settings. |
| first_indexed | 2024-04-12T23:33:18Z |
| format | Article |
| id | doaj.art-f7e2c49eba9d48fb8354f1514aaf6d93 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-12T23:33:18Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-f7e2c49eba9d48fb8354f1514aaf6d932022-12-22T03:12:14ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802021-06-01101110.1161/JAHA.120.020721Contributions of Costimulatory Molecule CD137 in Endothelial CellsWei Yuan0Chong Xu1Bo Li2Hao Xia3Yingjie Pan4Wei Zhong5Liangjie Xu6Rui Chen7Bin Wang8Department of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang ChinaDepartment of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang ChinaDepartment of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang ChinaDepartment of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang ChinaDepartment of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang ChinaDepartment of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang ChinaDepartment of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang ChinaDepartment of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang ChinaDepartment of Geriatrics Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology Wuhan ChinaAbstract CD137 (4‐1BB, tumor necrosis factor receptor superfamily 9) is a surface glycoprotein of the tumor necrosis factor receptor family that can be induced on a variety of immunocytes and nonimmune cells, including endothelial cells and smooth muscle cells. The importance of CD137 in immune response has been well recognized; however, the precise biological effects and underlying mechanisms of CD137 in endothelial cells are unclear. A single layer of cells called the endothelium constitutes the innermost layer of blood vessels including larger arteries, veins, the capillaries, and the lymphatic vessels. It not only acts as an important functional interface, but also participates in local inflammatory response. This review covers recent findings to illuminate the role of CD137 in endothelial cells in different pathophysiologic settings.https://www.ahajournals.org/doi/10.1161/JAHA.120.020721atherosclerosisCD137CD137Lendothelial cellvascular inflammation |
| spellingShingle | Wei Yuan Chong Xu Bo Li Hao Xia Yingjie Pan Wei Zhong Liangjie Xu Rui Chen Bin Wang Contributions of Costimulatory Molecule CD137 in Endothelial Cells Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atherosclerosis CD137 CD137L endothelial cell vascular inflammation |
| title | Contributions of Costimulatory Molecule CD137 in Endothelial Cells |
| title_full | Contributions of Costimulatory Molecule CD137 in Endothelial Cells |
| title_fullStr | Contributions of Costimulatory Molecule CD137 in Endothelial Cells |
| title_full_unstemmed | Contributions of Costimulatory Molecule CD137 in Endothelial Cells |
| title_short | Contributions of Costimulatory Molecule CD137 in Endothelial Cells |
| title_sort | contributions of costimulatory molecule cd137 in endothelial cells |
| topic | atherosclerosis CD137 CD137L endothelial cell vascular inflammation |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.120.020721 |
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