Evolution of codon usage in Zika virus genomes is host and vector specific
The codon usage patterns of viruses reflect the evolutionary changes that allow them to optimize their survival and adapt their fitness to the external environment and, most importantly, their hosts. Here we report the genotype-specific codon usage patterns of Zika virus (ZIKV) strains from the curr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2016-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1038/emi.2016.106 |
| _version_ | 1797679129683820544 |
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| author | Azeem Mehmood Butt Izza Nasrullah Raheel Qamar Yigang Tong |
| author_facet | Azeem Mehmood Butt Izza Nasrullah Raheel Qamar Yigang Tong |
| author_sort | Azeem Mehmood Butt |
| collection | DOAJ |
| description | The codon usage patterns of viruses reflect the evolutionary changes that allow them to optimize their survival and adapt their fitness to the external environment and, most importantly, their hosts. Here we report the genotype-specific codon usage patterns of Zika virus (ZIKV) strains from the current and previous outbreaks. Several genotype-specific and common codon usage traits were noted in the ZIKV coding sequences, indicating their independent evolutionary origins from a common ancestor. The overall influence of natural selection was more profound than that of mutation pressure, acting on a specific set of viral genes in the Asian-genotype ZIKV strains from the recent outbreak. An interplay between codon adaptation and deoptimization may have allowed the virus to adapt to multiple host and vectors and is reported for the first time in ZIKV genomes. Combining our codon analysis with geographical data on Aedes populations in the Americas suggested that ZIKV has evolved host- and vector-specific codon usage patterns to maintain successful replication and transmission chains within multiple hosts and vectors. |
| first_indexed | 2024-03-11T23:09:56Z |
| format | Article |
| id | doaj.art-f7e363f9169c4cd2a52496e2788b3a5e |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-11T23:09:56Z |
| publishDate | 2016-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-f7e363f9169c4cd2a52496e2788b3a5e2023-09-21T12:27:55ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512016-01-015111410.1038/emi.2016.106Evolution of codon usage in Zika virus genomes is host and vector specificAzeem Mehmood Butt0Izza Nasrullah1Raheel Qamar2Yigang Tong3Genomics Laboratory, Department of Biosciences, COMSATS Institute of Information Technology, Islamabad 45550, PakistanGenomics Laboratory, Department of Biosciences, COMSATS Institute of Information Technology, Islamabad 45550, PakistanGenomics Laboratory, Department of Biosciences, COMSATS Institute of Information Technology, Islamabad 45550, PakistanState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, ChinaThe codon usage patterns of viruses reflect the evolutionary changes that allow them to optimize their survival and adapt their fitness to the external environment and, most importantly, their hosts. Here we report the genotype-specific codon usage patterns of Zika virus (ZIKV) strains from the current and previous outbreaks. Several genotype-specific and common codon usage traits were noted in the ZIKV coding sequences, indicating their independent evolutionary origins from a common ancestor. The overall influence of natural selection was more profound than that of mutation pressure, acting on a specific set of viral genes in the Asian-genotype ZIKV strains from the recent outbreak. An interplay between codon adaptation and deoptimization may have allowed the virus to adapt to multiple host and vectors and is reported for the first time in ZIKV genomes. Combining our codon analysis with geographical data on Aedes populations in the Americas suggested that ZIKV has evolved host- and vector-specific codon usage patterns to maintain successful replication and transmission chains within multiple hosts and vectors.https://www.tandfonline.com/doi/10.1038/emi.2016.106codon usageevolutionmutation pressurenatural selectionZika virus |
| spellingShingle | Azeem Mehmood Butt Izza Nasrullah Raheel Qamar Yigang Tong Evolution of codon usage in Zika virus genomes is host and vector specific Emerging Microbes and Infections codon usage evolution mutation pressure natural selection Zika virus |
| title | Evolution of codon usage in Zika virus genomes is host and vector specific |
| title_full | Evolution of codon usage in Zika virus genomes is host and vector specific |
| title_fullStr | Evolution of codon usage in Zika virus genomes is host and vector specific |
| title_full_unstemmed | Evolution of codon usage in Zika virus genomes is host and vector specific |
| title_short | Evolution of codon usage in Zika virus genomes is host and vector specific |
| title_sort | evolution of codon usage in zika virus genomes is host and vector specific |
| topic | codon usage evolution mutation pressure natural selection Zika virus |
| url | https://www.tandfonline.com/doi/10.1038/emi.2016.106 |
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