Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer : A Mono-Institutional Series
Background The development of new metabolic diagnostic imaging PET is changing the history of metastatic prostate cancer (pCa), identifying situations of progression with a low disease burden; radiation treatment of metabolically active oligometastatic sites has been shown to be effective to prolong...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Asian Medical Press Ltd.(H.K.)
2022-10-01
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| Series: | Annals of Urologic Oncology |
| Subjects: | |
| Online Access: | http://auo.asmepress.com/articles/new-26-3.html |
| _version_ | 1811227127236788224 |
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| author | Riccardo Vigna-Taglianti Alberto Boriano Anna Maria Merlotti Stefania Martini Gianello Luca Salvatore Solla Spinelli Lavinia Francesco Olivero Fabrizio Bergesio Adriano De Maggi Alessia Reali Elvio Grazioso Russi |
| author_facet | Riccardo Vigna-Taglianti Alberto Boriano Anna Maria Merlotti Stefania Martini Gianello Luca Salvatore Solla Spinelli Lavinia Francesco Olivero Fabrizio Bergesio Adriano De Maggi Alessia Reali Elvio Grazioso Russi |
| author_sort | Riccardo Vigna-Taglianti |
| collection | DOAJ |
| description | Background The development of new metabolic diagnostic imaging PET is changing the history of metastatic prostate cancer (pCa), identifying situations of progression with a low disease burden; radiation treatment of metabolically active oligometastatic sites has been shown to be effective to prolong patient survival. In the scenario of oligometastatic disease to pelvic lymph nodes there is no uniform consensus on treatment volumes and radiotherapy doses to use.
Methods We retrospectively assessed a series of 50 patients treated from 2015 to 2021 at our center who presented with recurrent pelvic lymph node pCa disease with 1-3 lymph-nodes lateralized to one side of the pelvis. Patients were treated with intensity modulated Rapid Arc radiotherapy (IMRT), limiting the treatment volume to the chain of the affected side only. During the follow-up, the patients who presented a biochemical recurrence of the disease were evaluated by PET.
Results The biochemical progression-free survival and the metastatic progression-free survival were respectively 36% and 49% at 5 years. 22/50 patients presented a documented recurrence on PET. Only one patient presented a relapse within the irradiated volume and no patient presented a relapse on the contralateral pelvic lymph node chain. No patient had gastrointestinal toxicity > grade 1 RTOG.
Conclusion Treatment of patients with oligorecurrent (1-3 lesions) pelvic pCa, limiting the volume of irradiation to only one side of the affected lymph node chain, results in good biochemical disease control and presents a low risk of neoplastic contralateral progression. |
| first_indexed | 2024-04-12T09:36:14Z |
| format | Article |
| id | doaj.art-f7e406eba6c143ada24e8f5505827404 |
| institution | Directory Open Access Journal |
| issn | 2617-7765 2617-7773 |
| language | English |
| last_indexed | 2024-04-12T09:36:14Z |
| publishDate | 2022-10-01 |
| publisher | Asian Medical Press Ltd.(H.K.) |
| record_format | Article |
| series | Annals of Urologic Oncology |
| spelling | doaj.art-f7e406eba6c143ada24e8f55058274042022-12-22T03:38:13ZengAsian Medical Press Ltd.(H.K.)Annals of Urologic Oncology2617-77652617-77732022-10-0151810.32948/auo.2022.09.30Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer : A Mono-Institutional SeriesRiccardo Vigna-Taglianti0 Alberto Boriano1 Anna Maria Merlotti2Stefania Martini3Gianello Luca4Salvatore Solla5Spinelli Lavinia6 Francesco Olivero7 Fabrizio Bergesio8Adriano De Maggi9Alessia Reali10 Elvio Grazioso Russi11Radiation Oncology Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Medical Physics Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Radiation Oncology Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Radiation Oncology Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Radiation Oncology Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Radiation Oncology Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Radiation Oncology Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Medical Physics Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Medical Physics Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Medical Physics Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Radiation Oncology S.S., Michele and Pietro Ferrero Hospital, Verduno (CN), Italy.Radiation Oncology Department, Santa Croce and Carle Hospital, 12100, Cuneo, Italy.Background The development of new metabolic diagnostic imaging PET is changing the history of metastatic prostate cancer (pCa), identifying situations of progression with a low disease burden; radiation treatment of metabolically active oligometastatic sites has been shown to be effective to prolong patient survival. In the scenario of oligometastatic disease to pelvic lymph nodes there is no uniform consensus on treatment volumes and radiotherapy doses to use. Methods We retrospectively assessed a series of 50 patients treated from 2015 to 2021 at our center who presented with recurrent pelvic lymph node pCa disease with 1-3 lymph-nodes lateralized to one side of the pelvis. Patients were treated with intensity modulated Rapid Arc radiotherapy (IMRT), limiting the treatment volume to the chain of the affected side only. During the follow-up, the patients who presented a biochemical recurrence of the disease were evaluated by PET. Results The biochemical progression-free survival and the metastatic progression-free survival were respectively 36% and 49% at 5 years. 22/50 patients presented a documented recurrence on PET. Only one patient presented a relapse within the irradiated volume and no patient presented a relapse on the contralateral pelvic lymph node chain. No patient had gastrointestinal toxicity > grade 1 RTOG. Conclusion Treatment of patients with oligorecurrent (1-3 lesions) pelvic pCa, limiting the volume of irradiation to only one side of the affected lymph node chain, results in good biochemical disease control and presents a low risk of neoplastic contralateral progression.http://auo.asmepress.com/articles/new-26-3.htmlprostate cancerenrtsbrtsalvageoligometastatic |
| spellingShingle | Riccardo Vigna-Taglianti Alberto Boriano Anna Maria Merlotti Stefania Martini Gianello Luca Salvatore Solla Spinelli Lavinia Francesco Olivero Fabrizio Bergesio Adriano De Maggi Alessia Reali Elvio Grazioso Russi Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer : A Mono-Institutional Series Annals of Urologic Oncology prostate cancer enrt sbrt salvage oligometastatic |
| title | Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer : A Mono-Institutional Series |
| title_full | Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer : A Mono-Institutional Series |
| title_fullStr | Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer : A Mono-Institutional Series |
| title_full_unstemmed | Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer : A Mono-Institutional Series |
| title_short | Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer : A Mono-Institutional Series |
| title_sort | long term results of elective nodal salvage radiotherapy in oligometastatic prostate cancer a mono institutional series |
| topic | prostate cancer enrt sbrt salvage oligometastatic |
| url | http://auo.asmepress.com/articles/new-26-3.html |
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