Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytes
Perfluorooctanoic acid (PFOA), commonly found in drinking water, leads to widespread exposure through skin contact, inhalation, and ingestion, resulting in detectable levels of PFOA in the bloodstream. In this study, we found that exposure to PFOA disrupts cardiac function in human induced pluripote...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324002458 |
| _version_ | 1797261880506449920 |
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| author | Moon Yi Ko Sun-Hwa Chon Heejin Park Euijun Min Younhee Kim Sin-Woo Cha Joung-Wook Seo Byoung-Seok Lee Minhan Ka Sung-Ae Hyun |
| author_facet | Moon Yi Ko Sun-Hwa Chon Heejin Park Euijun Min Younhee Kim Sin-Woo Cha Joung-Wook Seo Byoung-Seok Lee Minhan Ka Sung-Ae Hyun |
| author_sort | Moon Yi Ko |
| collection | DOAJ |
| description | Perfluorooctanoic acid (PFOA), commonly found in drinking water, leads to widespread exposure through skin contact, inhalation, and ingestion, resulting in detectable levels of PFOA in the bloodstream. In this study, we found that exposure to PFOA disrupts cardiac function in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). We observed reductions in field and action potentials in hiPSC-CMs exposed to PFOA. Furthermore, PFOA demonstrated a dose-dependent inhibitory effect on various ion channels, including the calcium, sodium, and potassium channels. Additionally, we noted dose-dependent inhibition of the expression of these ion channels in hiPSC-CMs following exposure to PFOA. These findings suggest that PFOA exposure can impair cardiac ion channel function and decrease the transcription of genes associated with these channels, potentially contributing to cardiac dysfunction such as arrhythmias. Our study sheds light on the electrophysiological and epigenetic consequences of PFOA-induced cardiac dysfunction, underscoring the importance of further research on the cardiovascular effects of perfluorinated compounds (PFCs). |
| first_indexed | 2024-03-07T14:02:35Z |
| format | Article |
| id | doaj.art-f7e4d15192cb4717883818586e06e37e |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-24T23:48:15Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-f7e4d15192cb4717883818586e06e37e2024-03-15T04:42:56ZengElsevierEcotoxicology and Environmental Safety0147-65132024-03-01273116170Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytesMoon Yi Ko0Sun-Hwa Chon1Heejin Park2Euijun Min3Younhee Kim4Sin-Woo Cha5Joung-Wook Seo6Byoung-Seok Lee7Minhan Ka8Sung-Ae Hyun9Department of Advanced Toxicology Research, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of KoreaDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of Korea; Graduate School of Pre-Clinical Laboratory Science, Konyang University, Daejeon 35365, Republic of KoreaDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of KoreaDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of KoreaDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of KoreaDepartment of Nonclinical Studies, Korea Institute of Toxicology, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of KoreaDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of KoreaDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of Korea; Corresponding authors.Department of Advanced Toxicology Research, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of Korea; Corresponding authors.Department of Advanced Toxicology Research, Korea Institute of Toxicology, KRICT, Daejeon 34114, Republic of Korea; Corresponding authors.Perfluorooctanoic acid (PFOA), commonly found in drinking water, leads to widespread exposure through skin contact, inhalation, and ingestion, resulting in detectable levels of PFOA in the bloodstream. In this study, we found that exposure to PFOA disrupts cardiac function in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). We observed reductions in field and action potentials in hiPSC-CMs exposed to PFOA. Furthermore, PFOA demonstrated a dose-dependent inhibitory effect on various ion channels, including the calcium, sodium, and potassium channels. Additionally, we noted dose-dependent inhibition of the expression of these ion channels in hiPSC-CMs following exposure to PFOA. These findings suggest that PFOA exposure can impair cardiac ion channel function and decrease the transcription of genes associated with these channels, potentially contributing to cardiac dysfunction such as arrhythmias. Our study sheds light on the electrophysiological and epigenetic consequences of PFOA-induced cardiac dysfunction, underscoring the importance of further research on the cardiovascular effects of perfluorinated compounds (PFCs).http://www.sciencedirect.com/science/article/pii/S0147651324002458Perfluorooctanoic acid (PFOA)Cardiac dysfunctionField potentialsCardiac ion channels |
| spellingShingle | Moon Yi Ko Sun-Hwa Chon Heejin Park Euijun Min Younhee Kim Sin-Woo Cha Joung-Wook Seo Byoung-Seok Lee Minhan Ka Sung-Ae Hyun Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytes Ecotoxicology and Environmental Safety Perfluorooctanoic acid (PFOA) Cardiac dysfunction Field potentials Cardiac ion channels |
| title | Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytes |
| title_full | Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytes |
| title_fullStr | Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytes |
| title_full_unstemmed | Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytes |
| title_short | Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytes |
| title_sort | perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell derived cardiomyocytes |
| topic | Perfluorooctanoic acid (PFOA) Cardiac dysfunction Field potentials Cardiac ion channels |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324002458 |
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