BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas
Although several biomarkers have been identified to predict the prognosis of lower-grade (Grade II/III) gliomas (LGGs), we still need to identify new markers to facilitate those well-known markers to obtain more accurate prognosis prediction in LGGs. Bioinformatics data from The Cancer Genome Atlas...
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MDPI AG
2021-07-01
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| Online Access: | https://www.mdpi.com/2079-7737/10/8/701 |
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| author | Shang-Pen Huang Chien-Hsiu Li Wei-Min Chang Yuan-Feng Lin |
| author_facet | Shang-Pen Huang Chien-Hsiu Li Wei-Min Chang Yuan-Feng Lin |
| author_sort | Shang-Pen Huang |
| collection | DOAJ |
| description | Although several biomarkers have been identified to predict the prognosis of lower-grade (Grade II/III) gliomas (LGGs), we still need to identify new markers to facilitate those well-known markers to obtain more accurate prognosis prediction in LGGs. Bioinformatics data from The Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA), and the Cancer Cell Line Encyclopedia (CCLE) datasets were used as the research materials. In total, 34 genes associated with the HIF1A pathway were analyzed using the hierarchical method to search for the most compatible gene. The BICD cargo adaptor 1 (BICD1) gene (<i>BICD1</i>) was shown to be significantly correlated with The hypoxic inducible factor 1A (HIF1A) expression, the World Health Organization (WHO) grade, and <i>IDH1</i> mutation status. In addition, <i>BICD1</i> downregulation was significantly correlated with a higher Karnofsky performance score (KPS), <i>IDH1</i>/<i>TP53</i>/<i>ATRX</i> mutations, wild-type <i>EGFR,</i> and younger patient age in the enrolled LGG cohort. Moreover, <i>BICD1</i> expression was significantly upregulated in wild-type <i>IDH1</i> LGGs with <i>EGFR</i> mutations. Kaplan–Meier survival analysis revealed that <i>BICD1</i> downregulation predicts a favorable overall survival (OS) in LGG patients, especially in those with <i>IDH1</i> mutations. Intriguingly, we found a significant correlation between <i>BICD1</i> downregulation and a decreased level of <i>CD274</i>, <i>GSK3B</i>, <i>HGF</i>, or <i>STAT3</i> in LGGs. Our findings suggest that BICD1 downregulation could be a potential biomarker for a favorable prognosis of LGGs. |
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| language | English |
| last_indexed | 2024-03-10T09:00:57Z |
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| spelling | doaj.art-f7e4dff56be54c4fb8f4d1e13d640a7b2023-11-22T06:49:18ZengMDPI AGBiology2079-77372021-07-0110870110.3390/biology10080701BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade GliomasShang-Pen Huang0Chien-Hsiu Li1Wei-Min Chang2Yuan-Feng Lin3Center of General Education, Chung Hua University, Hsinchu 707, TaiwanGenomics Research Center, Academia Sinica, Taipei 11529, TaiwanSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 11031, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, TaiwanAlthough several biomarkers have been identified to predict the prognosis of lower-grade (Grade II/III) gliomas (LGGs), we still need to identify new markers to facilitate those well-known markers to obtain more accurate prognosis prediction in LGGs. Bioinformatics data from The Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA), and the Cancer Cell Line Encyclopedia (CCLE) datasets were used as the research materials. In total, 34 genes associated with the HIF1A pathway were analyzed using the hierarchical method to search for the most compatible gene. The BICD cargo adaptor 1 (BICD1) gene (<i>BICD1</i>) was shown to be significantly correlated with The hypoxic inducible factor 1A (HIF1A) expression, the World Health Organization (WHO) grade, and <i>IDH1</i> mutation status. In addition, <i>BICD1</i> downregulation was significantly correlated with a higher Karnofsky performance score (KPS), <i>IDH1</i>/<i>TP53</i>/<i>ATRX</i> mutations, wild-type <i>EGFR,</i> and younger patient age in the enrolled LGG cohort. Moreover, <i>BICD1</i> expression was significantly upregulated in wild-type <i>IDH1</i> LGGs with <i>EGFR</i> mutations. Kaplan–Meier survival analysis revealed that <i>BICD1</i> downregulation predicts a favorable overall survival (OS) in LGG patients, especially in those with <i>IDH1</i> mutations. Intriguingly, we found a significant correlation between <i>BICD1</i> downregulation and a decreased level of <i>CD274</i>, <i>GSK3B</i>, <i>HGF</i>, or <i>STAT3</i> in LGGs. Our findings suggest that BICD1 downregulation could be a potential biomarker for a favorable prognosis of LGGs.https://www.mdpi.com/2079-7737/10/8/701<i>BICD1</i>lower-grade gliomasbiomarkerprognosis<i>PD-L1</i> |
| spellingShingle | Shang-Pen Huang Chien-Hsiu Li Wei-Min Chang Yuan-Feng Lin BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas Biology <i>BICD1</i> lower-grade gliomas biomarker prognosis <i>PD-L1</i> |
| title | BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas |
| title_full | BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas |
| title_fullStr | BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas |
| title_full_unstemmed | BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas |
| title_short | BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas |
| title_sort | bicd cargo adaptor 1 bicd1 downregulation correlates with a decreased level of pd l1 and predicts a favorable prognosis in patients with idh1 mutant lower grade gliomas |
| topic | <i>BICD1</i> lower-grade gliomas biomarker prognosis <i>PD-L1</i> |
| url | https://www.mdpi.com/2079-7737/10/8/701 |
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