Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain
Abstract Background Human papillomavirus (HPV) bivalent and quadrivalent vaccines have been widely implemented in worldwide organized immunization programs. A nonavalent HPV vaccine is now available in several countries. The objective was to describe the fraction of squamous non-invasive high-grade...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Virology Journal |
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| Online Access: | http://link.springer.com/article/10.1186/s12985-017-0879-1 |
| _version_ | 1819152751612919808 |
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| author | S. Perez A. Iñarrea R. Pérez-Tanoira M. Gil E. López-Díez O. Valenzuela M. Porto L. Alberte-Lista M. A. Peteiro-Cancelo A. Treinta R. Carballo M. C. Reboredo M. E. Alvarez-Argüelles M. J. Purriños |
| author_facet | S. Perez A. Iñarrea R. Pérez-Tanoira M. Gil E. López-Díez O. Valenzuela M. Porto L. Alberte-Lista M. A. Peteiro-Cancelo A. Treinta R. Carballo M. C. Reboredo M. E. Alvarez-Argüelles M. J. Purriños |
| author_sort | S. Perez |
| collection | DOAJ |
| description | Abstract Background Human papillomavirus (HPV) bivalent and quadrivalent vaccines have been widely implemented in worldwide organized immunization programs. A nonavalent HPV vaccine is now available in several countries. The objective was to describe the fraction of squamous non-invasive high-grade cervical intraepithelial lesions attributable to genotypes targeted by bi-quadrivalent vaccines and by nonavalent vaccine according to age and diagnosis in women living in the city of Vigo (Galicia, Spain). Methods Cervical scrapings (2009–2014) of women with histological diagnosis of cervical intraepithelial neoplasia grade 2 (CIN2, n = 145) and grade 3-carcinoma in situ (CIN3-CIS, n = 244) were tested with Linear Array HPV Genotyping test (Roche diagnostics, Mannheim, Germany). Hierarchical estimation of the fraction attributable to HPV 16/18 or HPV 31/33/45/52/58 detected alone or in combination was calculated. Absolute additional fraction attributable to genotypes targeted by nonavalent vaccine compared to genotypes targeted by bi-quadrivalent vaccines was calculated as the increment of attributable cases with respect to all studied cases. Age group 1, 2 and 3 included women 18 to 34, 35–44 and ≥45 years old, respectively. EPIDAT 3.1 was used. Results Fraction attributable to genotypes targeted by bi-quadrivalent vaccines was 59% CIN2 vs. 69% CIN3-CIS (p < 0.001). It was 63/51/50% of CIN2 and 78/66/45% of CIN3-CIS in age group 1, 2, 3, respectively. Fraction attributable to genotypes targeted by nonavalent vaccine was 86% CIN2 and 86% CIN3-CIS. It was 87/91/75% of CIN2 and 90/86/76% of CIN3-CIS in age group 1, 2, 3, respectively. Fraction attributable to genotypes targeted by these vaccines tended to decrease as age increased (p-trend <0.05). Globally, absolute additional attributable fraction was 16%, 26% and 29% in age group 1, 2 and 3, respectively (p < 0.005). Conclusions Absolute additional fraction of CIN2 and CIN3-CIS attributable to genotypes targeted by nonavalent vaccine was observed in women of any age, especially in those over 35 years old. |
| first_indexed | 2024-12-22T14:54:16Z |
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| id | doaj.art-f7e4fb41cc974876a5f0d067c8aa94b6 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-22T14:54:16Z |
| publishDate | 2017-11-01 |
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| series | Virology Journal |
| spelling | doaj.art-f7e4fb41cc974876a5f0d067c8aa94b62022-12-21T18:22:16ZengBMCVirology Journal1743-422X2017-11-011411710.1186/s12985-017-0879-1Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, SpainS. Perez0A. Iñarrea1R. Pérez-Tanoira2M. Gil3E. López-Díez4O. Valenzuela5M. Porto6L. Alberte-Lista7M. A. Peteiro-Cancelo8A. Treinta9R. Carballo10M. C. Reboredo11M. E. Alvarez-Argüelles12M. J. Purriños13Microbiology Department, Institute of Biomedical Research of Vigo, University Hospital of VigoGynecology Department, University Hospital of VigoInternal Medicine Department, Hospital Fundación Jiménez DíazGynecology Department, University Hospital of VigoUrology Department, University Hospital of VigoGynecology Department, University Hospital of VigoGynecology Department, University Hospital of VigoPathology Department, University Hospital of VigoPathology Department, University Hospital of VigoMicrobiology Department, Institute of Biomedical Research of Vigo, University Hospital of VigoMicrobiology Department, Institute of Biomedical Research of Vigo, University Hospital of VigoGynecology Department, University Hospital of VigoVirology Department, Central University Hospital of AsturiasHealth and Epidemiology Department. Innovation and management of public health. Consellería de Sanidade, Xunta de GaliciaAbstract Background Human papillomavirus (HPV) bivalent and quadrivalent vaccines have been widely implemented in worldwide organized immunization programs. A nonavalent HPV vaccine is now available in several countries. The objective was to describe the fraction of squamous non-invasive high-grade cervical intraepithelial lesions attributable to genotypes targeted by bi-quadrivalent vaccines and by nonavalent vaccine according to age and diagnosis in women living in the city of Vigo (Galicia, Spain). Methods Cervical scrapings (2009–2014) of women with histological diagnosis of cervical intraepithelial neoplasia grade 2 (CIN2, n = 145) and grade 3-carcinoma in situ (CIN3-CIS, n = 244) were tested with Linear Array HPV Genotyping test (Roche diagnostics, Mannheim, Germany). Hierarchical estimation of the fraction attributable to HPV 16/18 or HPV 31/33/45/52/58 detected alone or in combination was calculated. Absolute additional fraction attributable to genotypes targeted by nonavalent vaccine compared to genotypes targeted by bi-quadrivalent vaccines was calculated as the increment of attributable cases with respect to all studied cases. Age group 1, 2 and 3 included women 18 to 34, 35–44 and ≥45 years old, respectively. EPIDAT 3.1 was used. Results Fraction attributable to genotypes targeted by bi-quadrivalent vaccines was 59% CIN2 vs. 69% CIN3-CIS (p < 0.001). It was 63/51/50% of CIN2 and 78/66/45% of CIN3-CIS in age group 1, 2, 3, respectively. Fraction attributable to genotypes targeted by nonavalent vaccine was 86% CIN2 and 86% CIN3-CIS. It was 87/91/75% of CIN2 and 90/86/76% of CIN3-CIS in age group 1, 2, 3, respectively. Fraction attributable to genotypes targeted by these vaccines tended to decrease as age increased (p-trend <0.05). Globally, absolute additional attributable fraction was 16%, 26% and 29% in age group 1, 2 and 3, respectively (p < 0.005). Conclusions Absolute additional fraction of CIN2 and CIN3-CIS attributable to genotypes targeted by nonavalent vaccine was observed in women of any age, especially in those over 35 years old.http://link.springer.com/article/10.1186/s12985-017-0879-1Nonavalent vaccineHPVPotential impactCervical lesionAdditional impact |
| spellingShingle | S. Perez A. Iñarrea R. Pérez-Tanoira M. Gil E. López-Díez O. Valenzuela M. Porto L. Alberte-Lista M. A. Peteiro-Cancelo A. Treinta R. Carballo M. C. Reboredo M. E. Alvarez-Argüelles M. J. Purriños Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain Virology Journal Nonavalent vaccine HPV Potential impact Cervical lesion Additional impact |
| title | Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain |
| title_full | Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain |
| title_fullStr | Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain |
| title_full_unstemmed | Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain |
| title_short | Fraction of high-grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent HPV vaccine in Galicia, Spain |
| title_sort | fraction of high grade cervical intraepithelial lesions attributable to genotypes targeted by a nonavalent hpv vaccine in galicia spain |
| topic | Nonavalent vaccine HPV Potential impact Cervical lesion Additional impact |
| url | http://link.springer.com/article/10.1186/s12985-017-0879-1 |
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