Cellular and molecular characteristics of the premetastatic niches
Abstract The premetastatic niches (PMN) formed by primary tumor‐derived molecules regulate distant organs and tissues to further favor tumor colonization. Targeted PMN therapy may prevent tumor metastasis in the early stages, which is becoming increasingly important. At present, there is a lack of i...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-10-01
|
| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12356 |
| _version_ | 1827779275544068096 |
|---|---|
| author | Hongfei Liu Guoxin Zhang Ran Gao |
| author_facet | Hongfei Liu Guoxin Zhang Ran Gao |
| author_sort | Hongfei Liu |
| collection | DOAJ |
| description | Abstract The premetastatic niches (PMN) formed by primary tumor‐derived molecules regulate distant organs and tissues to further favor tumor colonization. Targeted PMN therapy may prevent tumor metastasis in the early stages, which is becoming increasingly important. At present, there is a lack of in‐depth understanding of the cellular and molecular characteristics of the PMN. Here, we summarize current research advances on the cellular and molecular characteristics of the PMN. We emphasize that PMN intervention is a potential therapeutic strategy for early prevention of tumor metastasis, which provides a promising basis for future research and clinical application. |
| first_indexed | 2024-03-11T14:47:31Z |
| format | Article |
| id | doaj.art-f7e61f37899b4cb7bbaa36d9a2cd3893 |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-03-11T14:47:31Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-f7e61f37899b4cb7bbaa36d9a2cd38932023-10-30T10:48:25ZengWileyAnimal Models and Experimental Medicine2576-20952023-10-016539940810.1002/ame2.12356Cellular and molecular characteristics of the premetastatic nichesHongfei Liu0Guoxin Zhang1Ran Gao2Department of Otolaryngology, Head and Neck Surgery Beijing Tongren Hospital, Capital Medical University Beijing ChinaNational Human Diseases Animal Model Resource Center, The Institute of Laboratory Animal Science Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaNational Human Diseases Animal Model Resource Center, The Institute of Laboratory Animal Science Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaAbstract The premetastatic niches (PMN) formed by primary tumor‐derived molecules regulate distant organs and tissues to further favor tumor colonization. Targeted PMN therapy may prevent tumor metastasis in the early stages, which is becoming increasingly important. At present, there is a lack of in‐depth understanding of the cellular and molecular characteristics of the PMN. Here, we summarize current research advances on the cellular and molecular characteristics of the PMN. We emphasize that PMN intervention is a potential therapeutic strategy for early prevention of tumor metastasis, which provides a promising basis for future research and clinical application.https://doi.org/10.1002/ame2.12356extracellular vesiclesimmunosuppressionpremetastatic nichestumor metastasis |
| spellingShingle | Hongfei Liu Guoxin Zhang Ran Gao Cellular and molecular characteristics of the premetastatic niches Animal Models and Experimental Medicine extracellular vesicles immunosuppression premetastatic niches tumor metastasis |
| title | Cellular and molecular characteristics of the premetastatic niches |
| title_full | Cellular and molecular characteristics of the premetastatic niches |
| title_fullStr | Cellular and molecular characteristics of the premetastatic niches |
| title_full_unstemmed | Cellular and molecular characteristics of the premetastatic niches |
| title_short | Cellular and molecular characteristics of the premetastatic niches |
| title_sort | cellular and molecular characteristics of the premetastatic niches |
| topic | extracellular vesicles immunosuppression premetastatic niches tumor metastasis |
| url | https://doi.org/10.1002/ame2.12356 |
| work_keys_str_mv | AT hongfeiliu cellularandmolecularcharacteristicsofthepremetastaticniches AT guoxinzhang cellularandmolecularcharacteristicsofthepremetastaticniches AT rangao cellularandmolecularcharacteristicsofthepremetastaticniches |