Mechanisms of wound repair in crayfish
their regulation using the crayfish as a model system. Injuries to integument precipitate a cascade of cellular events that lead to rapid healing of the wound, regeneration of damaged tissues and repair of the integument. The first step in this cascade is hemolymph clotting and subsequent melanizati...
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| Format: | Article |
| Language: | English |
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University of Modena and Reggio Emilia
2009-09-01
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| Series: | Invertebrate Survival Journal |
| Subjects: | |
| Online Access: | http://www.isj.unimo.it/articoli/ISJ191.pdf |
| _version_ | 1818554537253797888 |
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| author | X Vafopoulou |
| author_facet | X Vafopoulou |
| author_sort | X Vafopoulou |
| collection | DOAJ |
| description | their regulation using the crayfish as a model system. Injuries to integument precipitate a cascade of cellular events that lead to rapid healing of the wound, regeneration of damaged tissues and repair of the integument. The first step in this cascade is hemolymph clotting and subsequent melanization, events documented thoroughly elsewhere and not discussed here. Wound healing and repair in crayfish involves the action of two physiological systems, the immune system and the neuroendocrine system regulating synthesis of the steroid molting hormones, ecdysteroids. Injury promotes a swift rise in hemolymph ecdysteroids to a low, sustained plateau, followed by a premolt peak and molting. The plateau is essential for wound healing since its principal targets are the circulating cells of the immune system, the hemocytes, and healthy epidermal cells and fibrocytes. Massive migration of these cells occurs under the wound and their concerted efforts under ecdysteroid control are paramount to wound healing and repair. These cells are likely engaged in physiological and biochemical activities that promote cell communication and cell to cell adhesion, removal of dead and harmful material and production of molecules essential to tissue regeneration. |
| first_indexed | 2024-12-12T09:41:07Z |
| format | Article |
| id | doaj.art-f7eb3eff3dd842ceb4456261c8814ffb |
| institution | Directory Open Access Journal |
| issn | 1824-307X |
| language | English |
| last_indexed | 2024-12-12T09:41:07Z |
| publishDate | 2009-09-01 |
| publisher | University of Modena and Reggio Emilia |
| record_format | Article |
| series | Invertebrate Survival Journal |
| spelling | doaj.art-f7eb3eff3dd842ceb4456261c8814ffb2022-12-22T00:28:33ZengUniversity of Modena and Reggio EmiliaInvertebrate Survival Journal1824-307X2009-09-0162125137Mechanisms of wound repair in crayfishX Vafopouloutheir regulation using the crayfish as a model system. Injuries to integument precipitate a cascade of cellular events that lead to rapid healing of the wound, regeneration of damaged tissues and repair of the integument. The first step in this cascade is hemolymph clotting and subsequent melanization, events documented thoroughly elsewhere and not discussed here. Wound healing and repair in crayfish involves the action of two physiological systems, the immune system and the neuroendocrine system regulating synthesis of the steroid molting hormones, ecdysteroids. Injury promotes a swift rise in hemolymph ecdysteroids to a low, sustained plateau, followed by a premolt peak and molting. The plateau is essential for wound healing since its principal targets are the circulating cells of the immune system, the hemocytes, and healthy epidermal cells and fibrocytes. Massive migration of these cells occurs under the wound and their concerted efforts under ecdysteroid control are paramount to wound healing and repair. These cells are likely engaged in physiological and biochemical activities that promote cell communication and cell to cell adhesion, removal of dead and harmful material and production of molecules essential to tissue regeneration.http://www.isj.unimo.it/articoli/ISJ191.pdfCrustaceaimmune systemecdysteroidshemocytesepidermisregeneration |
| spellingShingle | X Vafopoulou Mechanisms of wound repair in crayfish Invertebrate Survival Journal Crustacea immune system ecdysteroids hemocytes epidermis regeneration |
| title | Mechanisms of wound repair in crayfish |
| title_full | Mechanisms of wound repair in crayfish |
| title_fullStr | Mechanisms of wound repair in crayfish |
| title_full_unstemmed | Mechanisms of wound repair in crayfish |
| title_short | Mechanisms of wound repair in crayfish |
| title_sort | mechanisms of wound repair in crayfish |
| topic | Crustacea immune system ecdysteroids hemocytes epidermis regeneration |
| url | http://www.isj.unimo.it/articoli/ISJ191.pdf |
| work_keys_str_mv | AT xvafopoulou mechanismsofwoundrepairincrayfish |