Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer
Colitis-associated colorectal cancer is the most serious complication of ulcerative colitis. Long-term chronic inflammation increases the incidence of CAC in UC patients. Compared with sporadic colorectal cancer, CAC means multiple lesions, worse pathological type and worse prognosis. Macrophage is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1103617/full |
| _version_ | 1797869874834309120 |
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| author | Maorun Zhang Xiaoping Li Qi Zhang Jiahua Yang Gang Liu |
| author_facet | Maorun Zhang Xiaoping Li Qi Zhang Jiahua Yang Gang Liu |
| author_sort | Maorun Zhang |
| collection | DOAJ |
| description | Colitis-associated colorectal cancer is the most serious complication of ulcerative colitis. Long-term chronic inflammation increases the incidence of CAC in UC patients. Compared with sporadic colorectal cancer, CAC means multiple lesions, worse pathological type and worse prognosis. Macrophage is a kind of innate immune cell, which play an important role both in inflammatory response and tumor immunity. Macrophages are polarized into two phenotypes under different conditions: M1 and M2. In UC, enhanced macrophage infiltration produces a large number of inflammatory cytokines, which promote tumorigenesis of UC. M1 polarization has an anti-tumor effect after CAC formation, whereas M2 polarization promotes tumor growth. M2 polarization plays a tumor-promoting role. Some drugs have been shown to that prevent and treat CAC effectively by targeting macrophages. |
| first_indexed | 2024-04-10T00:19:22Z |
| format | Article |
| id | doaj.art-f7eb5159dcb6478b9ffbd233bbb6bd71 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T00:19:22Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f7eb5159dcb6478b9ffbd233bbb6bd712023-03-16T05:02:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11036171103617Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancerMaorun ZhangXiaoping LiQi ZhangJiahua YangGang LiuColitis-associated colorectal cancer is the most serious complication of ulcerative colitis. Long-term chronic inflammation increases the incidence of CAC in UC patients. Compared with sporadic colorectal cancer, CAC means multiple lesions, worse pathological type and worse prognosis. Macrophage is a kind of innate immune cell, which play an important role both in inflammatory response and tumor immunity. Macrophages are polarized into two phenotypes under different conditions: M1 and M2. In UC, enhanced macrophage infiltration produces a large number of inflammatory cytokines, which promote tumorigenesis of UC. M1 polarization has an anti-tumor effect after CAC formation, whereas M2 polarization promotes tumor growth. M2 polarization plays a tumor-promoting role. Some drugs have been shown to that prevent and treat CAC effectively by targeting macrophages.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1103617/fullulcerative colitiscolitis-associated colorectal cancermacrophage infiltrationmacrophage polarizationmacrophage |
| spellingShingle | Maorun Zhang Xiaoping Li Qi Zhang Jiahua Yang Gang Liu Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer Frontiers in Immunology ulcerative colitis colitis-associated colorectal cancer macrophage infiltration macrophage polarization macrophage |
| title | Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer |
| title_full | Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer |
| title_fullStr | Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer |
| title_full_unstemmed | Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer |
| title_short | Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer |
| title_sort | roles of macrophages on ulcerative colitis and colitis associated colorectal cancer |
| topic | ulcerative colitis colitis-associated colorectal cancer macrophage infiltration macrophage polarization macrophage |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1103617/full |
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