Obesity Promotes Liver Carcinogenesis via Mcl-1 Stabilization Independent of IL-6Rα Signaling

Obesity Promotes Liver Carcinogenesis via Mcl-1 Stabilization Independent of IL-6Rα Signaling

Obesity increases the incidence of hepatocellular carcinoma (HCC) development in part through the activation of obesity-associated proinflammatory signaling. Here, we show that in lean mice, abrogation of IL-6Rα signaling protects against diethylnitrosamine (DEN)-induced HCC development. HCC protect...

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Bibliographic Details
Main Authors: Sabine Gruber, Beate K. Straub, P. Justus Ackermann, Claudia M. Wunderlich, Jan Mauer, Jens M. Seeger, Hildegard Büning, Lukas Heukamp, Hamid Kashkar, Peter Schirmacher, Jens C. Brüning, F. Thomas Wunderlich
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003859

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http://www.sciencedirect.com/science/article/pii/S2211124713003859

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