Obesity Promotes Liver Carcinogenesis via Mcl-1 Stabilization Independent of IL-6Rα Signaling
Obesity increases the incidence of hepatocellular carcinoma (HCC) development in part through the activation of obesity-associated proinflammatory signaling. Here, we show that in lean mice, abrogation of IL-6Rα signaling protects against diethylnitrosamine (DEN)-induced HCC development. HCC protect...
Main Authors: | Sabine Gruber, Beate K. Straub, P. Justus Ackermann, Claudia M. Wunderlich, Jan Mauer, Jens M. Seeger, Hildegard Büning, Lukas Heukamp, Hamid Kashkar, Peter Schirmacher, Jens C. Brüning, F. Thomas Wunderlich |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2013-08-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713003859 |
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