Expanding functions of lipoprotein receptors
Lipoprotein receptors are evolutionarily ancient proteins that are expressed on the surface of many cell types. Beginning with the appearance of the first primitive multicellular organisms, several structurally and functionally distinct families of lipoprotein receptors evolved. Originally, these ce...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2009-01-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520306271 |
| _version_ | 1818899405134102528 |
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| author | Joachim Herz Ying Chen Irene Masiulis Li Zhou |
| author_facet | Joachim Herz Ying Chen Irene Masiulis Li Zhou |
| author_sort | Joachim Herz |
| collection | DOAJ |
| description | Lipoprotein receptors are evolutionarily ancient proteins that are expressed on the surface of many cell types. Beginning with the appearance of the first primitive multicellular organisms, several structurally and functionally distinct families of lipoprotein receptors evolved. Originally, these cell surface proteins were thought to merely mediate the traffic of lipids and nutrients between cells and, in some cases, by functioning as scavenger receptors, remove other kinds of macromolecules, such as proteases and protease inhibitors from the extracellular space and the cell surface. Over the last decade, this picture has fundamentally changed. We now appreciate that many of these receptors are not mere cargo transporters; they are deeply embedded in the machinery by which cells communicate with each other. By physically interacting and coevolving with fundamental signaling pathways, lipoprotein receptors have occupied essential and surprisingly diverse functions that are indispensable for integrating the complex web of cellular signal input during development and in differentiated tissues. |
| first_indexed | 2024-12-19T19:47:26Z |
| format | Article |
| id | doaj.art-f7edf6052d7841cea9201c2098ba1d85 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-19T19:47:26Z |
| publishDate | 2009-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-f7edf6052d7841cea9201c2098ba1d852022-12-21T20:08:07ZengElsevierJournal of Lipid Research0022-22752009-01-0150S287S292Expanding functions of lipoprotein receptorsJoachim Herz0Ying Chen1Irene Masiulis2Li Zhou3To whom correspondence should be addressed; Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046Lipoprotein receptors are evolutionarily ancient proteins that are expressed on the surface of many cell types. Beginning with the appearance of the first primitive multicellular organisms, several structurally and functionally distinct families of lipoprotein receptors evolved. Originally, these cell surface proteins were thought to merely mediate the traffic of lipids and nutrients between cells and, in some cases, by functioning as scavenger receptors, remove other kinds of macromolecules, such as proteases and protease inhibitors from the extracellular space and the cell surface. Over the last decade, this picture has fundamentally changed. We now appreciate that many of these receptors are not mere cargo transporters; they are deeply embedded in the machinery by which cells communicate with each other. By physically interacting and coevolving with fundamental signaling pathways, lipoprotein receptors have occupied essential and surprisingly diverse functions that are indispensable for integrating the complex web of cellular signal input during development and in differentiated tissues.http://www.sciencedirect.com/science/article/pii/S0022227520306271nervous systemApoer2VldlrLRP1LRP4 |
| spellingShingle | Joachim Herz Ying Chen Irene Masiulis Li Zhou Expanding functions of lipoprotein receptors Journal of Lipid Research nervous system Apoer2 Vldlr LRP1 LRP4 |
| title | Expanding functions of lipoprotein receptors |
| title_full | Expanding functions of lipoprotein receptors |
| title_fullStr | Expanding functions of lipoprotein receptors |
| title_full_unstemmed | Expanding functions of lipoprotein receptors |
| title_short | Expanding functions of lipoprotein receptors |
| title_sort | expanding functions of lipoprotein receptors |
| topic | nervous system Apoer2 Vldlr LRP1 LRP4 |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520306271 |
| work_keys_str_mv | AT joachimherz expandingfunctionsoflipoproteinreceptors AT yingchen expandingfunctionsoflipoproteinreceptors AT irenemasiulis expandingfunctionsoflipoproteinreceptors AT lizhou expandingfunctionsoflipoproteinreceptors |