Dietary fat intake and the risk of depression: the SUN Project.
Emerging evidence relates some nutritional factors to depression risk. However, there is a scarcity of longitudinal assessments on this relationship.To evaluate the association between fatty acid intake or the use of culinary fats and depression incidence in a Mediterranean population.Prospective co...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3027671?pdf=render |
| _version_ | 1811319741074112512 |
|---|---|
| author | Almudena Sánchez-Villegas Lisa Verberne Jokin De Irala Miguel Ruíz-Canela Estefanía Toledo Lluis Serra-Majem Miguel Angel Martínez-González |
| author_facet | Almudena Sánchez-Villegas Lisa Verberne Jokin De Irala Miguel Ruíz-Canela Estefanía Toledo Lluis Serra-Majem Miguel Angel Martínez-González |
| author_sort | Almudena Sánchez-Villegas |
| collection | DOAJ |
| description | Emerging evidence relates some nutritional factors to depression risk. However, there is a scarcity of longitudinal assessments on this relationship.To evaluate the association between fatty acid intake or the use of culinary fats and depression incidence in a Mediterranean population.Prospective cohort study (1999-2010) of 12,059 Spanish university graduates (mean age: 37.5 years) initially free of depression with permanently open enrolment. At baseline, a 136-item validated food frequency questionnaire was used to estimate the intake of fatty acids (saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA), trans unsaturated fatty acids (TFA) and monounsaturated fatty acids (MUFA) and culinary fats (olive oil, seed oils, butter and margarine) During follow-up participants were classified as incident cases of depression if they reported a new clinical diagnosis of depression by a physician and/or initiated the use of antidepressant drugs. Cox regression models were used to calculate Hazard Ratios (HR) of incident depression and their 95% confidence intervals (CI) for successive quintiles of fats.During follow-up (median: 6.1 years), 657 new cases of depression were identified. Multivariable-adjusted HR (95% CI) for depression incidence across successive quintiles of TFA intake were: 1 (ref), 1.08 (0.82-1.43), 1.17 (0.88-1.53), 1.28 (0.97-1.68), 1.42 (1.09-1.84) with a significant dose-response relationship (p for trend = 0.003). Results did not substantially change after adjusting for potential lifestyle or dietary confounders, including adherence to a Mediterranean Dietary Pattern. On the other hand, an inverse and significant dose-response relationship was obtained for MUFA (p for trend = 0.05) and PUFA (p for trend = 0.03) intake.A detrimental relationship was found between TFA intake and depression risk, whereas weak inverse associations were found for MUFA, PUFA and olive oil. These findings suggest that cardiovascular disease and depression may share some common nutritional determinants related to subtypes of fat intake. |
| first_indexed | 2024-04-13T12:47:56Z |
| format | Article |
| id | doaj.art-f7f0ff2bf2c64d6688043f37b27b1ccd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T12:47:56Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f7f0ff2bf2c64d6688043f37b27b1ccd2022-12-22T02:46:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0161e1626810.1371/journal.pone.0016268Dietary fat intake and the risk of depression: the SUN Project.Almudena Sánchez-VillegasLisa VerberneJokin De IralaMiguel Ruíz-CanelaEstefanía ToledoLluis Serra-MajemMiguel Angel Martínez-GonzálezEmerging evidence relates some nutritional factors to depression risk. However, there is a scarcity of longitudinal assessments on this relationship.To evaluate the association between fatty acid intake or the use of culinary fats and depression incidence in a Mediterranean population.Prospective cohort study (1999-2010) of 12,059 Spanish university graduates (mean age: 37.5 years) initially free of depression with permanently open enrolment. At baseline, a 136-item validated food frequency questionnaire was used to estimate the intake of fatty acids (saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA), trans unsaturated fatty acids (TFA) and monounsaturated fatty acids (MUFA) and culinary fats (olive oil, seed oils, butter and margarine) During follow-up participants were classified as incident cases of depression if they reported a new clinical diagnosis of depression by a physician and/or initiated the use of antidepressant drugs. Cox regression models were used to calculate Hazard Ratios (HR) of incident depression and their 95% confidence intervals (CI) for successive quintiles of fats.During follow-up (median: 6.1 years), 657 new cases of depression were identified. Multivariable-adjusted HR (95% CI) for depression incidence across successive quintiles of TFA intake were: 1 (ref), 1.08 (0.82-1.43), 1.17 (0.88-1.53), 1.28 (0.97-1.68), 1.42 (1.09-1.84) with a significant dose-response relationship (p for trend = 0.003). Results did not substantially change after adjusting for potential lifestyle or dietary confounders, including adherence to a Mediterranean Dietary Pattern. On the other hand, an inverse and significant dose-response relationship was obtained for MUFA (p for trend = 0.05) and PUFA (p for trend = 0.03) intake.A detrimental relationship was found between TFA intake and depression risk, whereas weak inverse associations were found for MUFA, PUFA and olive oil. These findings suggest that cardiovascular disease and depression may share some common nutritional determinants related to subtypes of fat intake.http://europepmc.org/articles/PMC3027671?pdf=render |
| spellingShingle | Almudena Sánchez-Villegas Lisa Verberne Jokin De Irala Miguel Ruíz-Canela Estefanía Toledo Lluis Serra-Majem Miguel Angel Martínez-González Dietary fat intake and the risk of depression: the SUN Project. PLoS ONE |
| title | Dietary fat intake and the risk of depression: the SUN Project. |
| title_full | Dietary fat intake and the risk of depression: the SUN Project. |
| title_fullStr | Dietary fat intake and the risk of depression: the SUN Project. |
| title_full_unstemmed | Dietary fat intake and the risk of depression: the SUN Project. |
| title_short | Dietary fat intake and the risk of depression: the SUN Project. |
| title_sort | dietary fat intake and the risk of depression the sun project |
| url | http://europepmc.org/articles/PMC3027671?pdf=render |
| work_keys_str_mv | AT almudenasanchezvillegas dietaryfatintakeandtheriskofdepressionthesunproject AT lisaverberne dietaryfatintakeandtheriskofdepressionthesunproject AT jokindeirala dietaryfatintakeandtheriskofdepressionthesunproject AT miguelruizcanela dietaryfatintakeandtheriskofdepressionthesunproject AT estefaniatoledo dietaryfatintakeandtheriskofdepressionthesunproject AT lluisserramajem dietaryfatintakeandtheriskofdepressionthesunproject AT miguelangelmartinezgonzalez dietaryfatintakeandtheriskofdepressionthesunproject |