A dual role of HIF1α in regulating osteogenesis–angiogenesis coupling

A dual role of HIF1α in regulating osteogenesis–angiogenesis coupling

Abstract Objectives The hypoxia-inducible factor 1-α (HIF1α), a key molecule in mediating bone-vessel crosstalk, has been considered a promising target for treating osteoporosis caused by gonadal hormones. However, senile osteoporosis, with accumulated senescent cells in aged bone, has a distinct pa...

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Bibliographic Details
Main Authors: Jingjing Shao, Shibo Liu, Min Zhang, Shujiang Chen, Shuaiqi Gan, Chenfeng Chen, Wenchuan Chen, Lei Li, Zhimin Zhu
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Stem Cell Research & Therapy
Subjects:
HIF1α
p53
ROS
Osteogenesis–angiogenesis coupling
Senile osteoporosis
Online Access:https://doi.org/10.1186/s13287-022-02742-1

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