Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action
The aerosol inhalation delivery of composite particles consisting of Ag nanoparticles enveloped by polyvinylpyrrolidone was investigated in experiments with mice. An ultrasonic nebulizing system was created for the generation of aerosols with a mean diameter and mass concentration of 700 ± 50 nm and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/10/1534 |
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| author | Sergey V. Valiulin Andrei A. Onischuk Alexandra P. Pyryaeva Sergey V. An’kov Anatoly M. Baklanov Nikolay N. Shkil Ekaterina V. Nefedova Kirill S. Ershov Tatyana G. Tolstikova Galina G. Dultseva |
| author_facet | Sergey V. Valiulin Andrei A. Onischuk Alexandra P. Pyryaeva Sergey V. An’kov Anatoly M. Baklanov Nikolay N. Shkil Ekaterina V. Nefedova Kirill S. Ershov Tatyana G. Tolstikova Galina G. Dultseva |
| author_sort | Sergey V. Valiulin |
| collection | DOAJ |
| description | The aerosol inhalation delivery of composite particles consisting of Ag nanoparticles enveloped by polyvinylpyrrolidone was investigated in experiments with mice. An ultrasonic nebulizing system was created for the generation of aerosols with a mean diameter and mass concentration of 700 ± 50 nm and 65 ± 5 mg/m<sup>3</sup>, respectively. The mass fraction of Ag in the composite particles was <i>α</i> = 0.061. The aerosol delivery was performed in a whole-body chamber with an exposition time of 20 min. Pharmacokinetic measurements were taken and the silver concentrations in the blood and lungs of the mice were measured as a function of time after exposition by means of electrothermal (graphite furnace) atomic absorption spectrometry. The inhalation dose and other pharmacokinetic parameters were determined. The antibacterial effect of aerosolized silver was assessed for mice infected with <i>Klebsiella pneumoniae 82</i> and <i>Staphylococcus aureus ATCC 25953</i>. The survival rate of the infected mice after the aerosol exposure demonstrated the high antibacterial efficiency of Ag nanoparticles after inhalation delivery. |
| first_indexed | 2024-03-10T21:29:55Z |
| format | Article |
| id | doaj.art-f7f22af3ff6f4222b7ab8e14c893c7ab |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T21:29:55Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-f7f22af3ff6f4222b7ab8e14c893c7ab2023-11-19T15:26:51ZengMDPI AGAntibiotics2079-63822023-10-011210153410.3390/antibiotics12101534Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial ActionSergey V. Valiulin0Andrei A. Onischuk1Alexandra P. Pyryaeva2Sergey V. An’kov3Anatoly M. Baklanov4Nikolay N. Shkil5Ekaterina V. Nefedova6Kirill S. Ershov7Tatyana G. Tolstikova8Galina G. Dultseva9Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya Str., 630090 Novosibirsk, RussiaVoevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya Str., 630090 Novosibirsk, RussiaVoevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya Str., 630090 Novosibirsk, RussiaVoevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya Str., 630090 Novosibirsk, RussiaVoevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya Str., 630090 Novosibirsk, RussiaSiberian Federal Scientific Center of Agro-BioTechnologies RAS, 630501 Krasnoobsk, RussiaSiberian Federal Scientific Center of Agro-BioTechnologies RAS, 630501 Krasnoobsk, RussiaVoevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya Str., 630090 Novosibirsk, RussiaVoevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya Str., 630090 Novosibirsk, RussiaVoevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya Str., 630090 Novosibirsk, RussiaThe aerosol inhalation delivery of composite particles consisting of Ag nanoparticles enveloped by polyvinylpyrrolidone was investigated in experiments with mice. An ultrasonic nebulizing system was created for the generation of aerosols with a mean diameter and mass concentration of 700 ± 50 nm and 65 ± 5 mg/m<sup>3</sup>, respectively. The mass fraction of Ag in the composite particles was <i>α</i> = 0.061. The aerosol delivery was performed in a whole-body chamber with an exposition time of 20 min. Pharmacokinetic measurements were taken and the silver concentrations in the blood and lungs of the mice were measured as a function of time after exposition by means of electrothermal (graphite furnace) atomic absorption spectrometry. The inhalation dose and other pharmacokinetic parameters were determined. The antibacterial effect of aerosolized silver was assessed for mice infected with <i>Klebsiella pneumoniae 82</i> and <i>Staphylococcus aureus ATCC 25953</i>. The survival rate of the infected mice after the aerosol exposure demonstrated the high antibacterial efficiency of Ag nanoparticles after inhalation delivery.https://www.mdpi.com/2079-6382/12/10/1534aerosol inhalation deliverysilver nanoparticlespharmacokineticsantibacterial activity |
| spellingShingle | Sergey V. Valiulin Andrei A. Onischuk Alexandra P. Pyryaeva Sergey V. An’kov Anatoly M. Baklanov Nikolay N. Shkil Ekaterina V. Nefedova Kirill S. Ershov Tatyana G. Tolstikova Galina G. Dultseva Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action Antibiotics aerosol inhalation delivery silver nanoparticles pharmacokinetics antibacterial activity |
| title | Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action |
| title_full | Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action |
| title_fullStr | Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action |
| title_full_unstemmed | Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action |
| title_short | Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action |
| title_sort | aerosol inhalation delivery of ag nanoparticles in mice pharmacokinetics and antibacterial action |
| topic | aerosol inhalation delivery silver nanoparticles pharmacokinetics antibacterial activity |
| url | https://www.mdpi.com/2079-6382/12/10/1534 |
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