Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment options
Abstract Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes dysregulation of vasodilatory and vasoconstrictive properties of smooth vascular...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-02-01
|
| Series: | Critical Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13054-020-2743-8 |
| _version_ | 1818388146822316032 |
|---|---|
| author | Laurence W. Busse Nicholas Barker Christopher Petersen |
| author_facet | Laurence W. Busse Nicholas Barker Christopher Petersen |
| author_sort | Laurence W. Busse |
| collection | DOAJ |
| description | Abstract Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes dysregulation of vasodilatory and vasoconstrictive properties of smooth vascular muscle cells. Specific bypass machine and patient factors play key roles in occurrence. Research into treatment of this syndrome is limited and extrapolated primarily from that pertaining to septic shock, but is evolving with the expanded use of catecholamine-sparing agents. Recent reports demonstrate potential benefit in novel treatment options, but large clinical trials are needed to confirm. |
| first_indexed | 2024-12-14T04:21:12Z |
| format | Article |
| id | doaj.art-f7f26645681f4205829d930e243e2db2 |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-12-14T04:21:12Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-f7f26645681f4205829d930e243e2db22022-12-21T23:17:22ZengBMCCritical Care1364-85352020-02-0124111110.1186/s13054-020-2743-8Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment optionsLaurence W. Busse0Nicholas Barker1Christopher Petersen2Department of Medicine, Emory University, Emory Critical Care CenterDepartment of Pharmacy, Emory St. Joseph’s HospitalDepartment of Pharmacy, Stanford Health Care, Palo AltoAbstract Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes dysregulation of vasodilatory and vasoconstrictive properties of smooth vascular muscle cells. Specific bypass machine and patient factors play key roles in occurrence. Research into treatment of this syndrome is limited and extrapolated primarily from that pertaining to septic shock, but is evolving with the expanded use of catecholamine-sparing agents. Recent reports demonstrate potential benefit in novel treatment options, but large clinical trials are needed to confirm.https://doi.org/10.1186/s13054-020-2743-8Vasoplegic syndromeShockDe-catecholaminizationHydroxocobalaminAngiotensin IICardiopulmonary bypass |
| spellingShingle | Laurence W. Busse Nicholas Barker Christopher Petersen Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment options Critical Care Vasoplegic syndrome Shock De-catecholaminization Hydroxocobalamin Angiotensin II Cardiopulmonary bypass |
| title | Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment options |
| title_full | Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment options |
| title_fullStr | Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment options |
| title_full_unstemmed | Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment options |
| title_short | Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment options |
| title_sort | vasoplegic syndrome following cardiothoracic surgery review of pathophysiology and update of treatment options |
| topic | Vasoplegic syndrome Shock De-catecholaminization Hydroxocobalamin Angiotensin II Cardiopulmonary bypass |
| url | https://doi.org/10.1186/s13054-020-2743-8 |
| work_keys_str_mv | AT laurencewbusse vasoplegicsyndromefollowingcardiothoracicsurgeryreviewofpathophysiologyandupdateoftreatmentoptions AT nicholasbarker vasoplegicsyndromefollowingcardiothoracicsurgeryreviewofpathophysiologyandupdateoftreatmentoptions AT christopherpetersen vasoplegicsyndromefollowingcardiothoracicsurgeryreviewofpathophysiologyandupdateoftreatmentoptions |