Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model.
The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that the metabolic dysfunction accelerates AD development, including exac...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0221828 |
| _version_ | 1818725844419346432 |
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| author | Jared D Hoffman Lucille M Yanckello George Chlipala Tyler C Hammond Scott D McCulloch Ishita Parikh Sydney Sun Josh M Morganti Stefan J Green Ai-Ling Lin |
| author_facet | Jared D Hoffman Lucille M Yanckello George Chlipala Tyler C Hammond Scott D McCulloch Ishita Parikh Sydney Sun Josh M Morganti Stefan J Green Ai-Ling Lin |
| author_sort | Jared D Hoffman |
| collection | DOAJ |
| description | The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that the metabolic dysfunction accelerates AD development, including exacerbated amyloid-beta (Aβ) retention, neuroinflammation and cognitive decline. Therefore, preserving metabolic function early on may be critical to reducing the risk for AD. Here, we show that inulin increases beneficial microbiota and decreases harmful microbiota in the feces of young, asymptomatic APOE4 transgenic (E4FAD) mice and enhances metabolism in the cecum, periphery and brain, as demonstrated by increases in the levels of SCFAs, tryptophan-derived metabolites, bile acids, glycolytic metabolites and scyllo-inositol. We show that inulin also reduces inflammatory gene expression in the hippocampus. This knowledge can be utilized to design early precision nutrition intervention strategies that use a prebiotic diet to enhance systemic metabolism and may be useful for reducing AD risk in asymptomatic APOE4 carriers. |
| first_indexed | 2024-12-17T21:48:46Z |
| format | Article |
| id | doaj.art-f7f2ee8277c149b28149183347404334 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T21:48:46Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f7f2ee8277c149b281491833474043342022-12-21T21:31:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01148e022182810.1371/journal.pone.0221828Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model.Jared D HoffmanLucille M YanckelloGeorge ChlipalaTyler C HammondScott D McCullochIshita ParikhSydney SunJosh M MorgantiStefan J GreenAi-Ling LinThe apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that the metabolic dysfunction accelerates AD development, including exacerbated amyloid-beta (Aβ) retention, neuroinflammation and cognitive decline. Therefore, preserving metabolic function early on may be critical to reducing the risk for AD. Here, we show that inulin increases beneficial microbiota and decreases harmful microbiota in the feces of young, asymptomatic APOE4 transgenic (E4FAD) mice and enhances metabolism in the cecum, periphery and brain, as demonstrated by increases in the levels of SCFAs, tryptophan-derived metabolites, bile acids, glycolytic metabolites and scyllo-inositol. We show that inulin also reduces inflammatory gene expression in the hippocampus. This knowledge can be utilized to design early precision nutrition intervention strategies that use a prebiotic diet to enhance systemic metabolism and may be useful for reducing AD risk in asymptomatic APOE4 carriers.https://doi.org/10.1371/journal.pone.0221828 |
| spellingShingle | Jared D Hoffman Lucille M Yanckello George Chlipala Tyler C Hammond Scott D McCulloch Ishita Parikh Sydney Sun Josh M Morganti Stefan J Green Ai-Ling Lin Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. PLoS ONE |
| title | Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. |
| title_full | Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. |
| title_fullStr | Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. |
| title_full_unstemmed | Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. |
| title_short | Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. |
| title_sort | dietary inulin alters the gut microbiome enhances systemic metabolism and reduces neuroinflammation in an apoe4 mouse model |
| url | https://doi.org/10.1371/journal.pone.0221828 |
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