Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model.

Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model.

The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that the metabolic dysfunction accelerates AD development, including exac...

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Bibliographic Details
Main Authors: Jared D Hoffman, Lucille M Yanckello, George Chlipala, Tyler C Hammond, Scott D McCulloch, Ishita Parikh, Sydney Sun, Josh M Morganti, Stefan J Green, Ai-Ling Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221828

Internet

https://doi.org/10.1371/journal.pone.0221828

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