Molecular mechanism by which CDCP1 promotes proneural-mesenchymal transformation in primary glioblastoma

Molecular mechanism by which CDCP1 promotes proneural-mesenchymal transformation in primary glioblastoma

Abstract Background Compared with the proneural (PN) subtype of glioblastoma (GBM), the mesenchymal (MES) subtype is more invasive and immune evasive and is closely related to poor prognosis. Here, we used transcriptome data and experimental evidence to indicate that CUB domain-containing protein 1...

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Bibliographic Details
Main Authors: Zhiying Lin, Zhu Zhang, Haojie Zheng, Haiyan Xu, Yajuan Wang, Chao Chen, Junlu Liu, Guozhong Yi, Zhiyong Li, Xiaoyan Wang, Guanglong Huang
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Cancer Cell International
Subjects:
Glioma
CDCP1
Proneural-mesenchymal transition
Epithelial-mesenchymal transition
Prognostic risk model
Online Access:https://doi.org/10.1186/s12935-021-02373-1

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