Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects
OBJECTIVES: To compare the metabolic, hemodynamic, autonomic, and endothelial responses to short-term red wine consumption in subjects with hypercholesterolemia or arterial hypertension, and healthy controls. METHODS: Subjects with hypercholesterolemia (n=10) or arterial hypertension (n=9), or healt...
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| Format: | Article |
| Language: | English |
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Elsevier España
2009-05-01
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| Series: | Clinics |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322009000500011 |
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| author | Ana CM Andrade Fernando HY Cesena Fernanda M Consolim-Colombo Silmara R Coimbra Alexandre M Benjó Eduardo M Krieger Protasio Lemos da Luz |
| author_facet | Ana CM Andrade Fernando HY Cesena Fernanda M Consolim-Colombo Silmara R Coimbra Alexandre M Benjó Eduardo M Krieger Protasio Lemos da Luz |
| author_sort | Ana CM Andrade |
| collection | DOAJ |
| description | OBJECTIVES: To compare the metabolic, hemodynamic, autonomic, and endothelial responses to short-term red wine consumption in subjects with hypercholesterolemia or arterial hypertension, and healthy controls. METHODS: Subjects with hypercholesterolemia (n=10) or arterial hypertension (n=9), or healthy controls (n=7) were given red wine (250 mL/night) for 15 days. Analyses were performed before and after red wine intake. RESULTS: Red wine significantly increased the plasma levels of HDL-cholesterol in the controls, but not in the other groups. The effects on hemodynamic measurements were mild, non-significantly more prominent in healthy subjects, and exhibited high interindividual variability. Across all participants, mean blood pressure decreased 7 mmHg (p <0.01) and systemic vascular resistance decreased 7% (p = 0.05). Heart rate and cardiac output did not significantly change in any group. Red wine enhanced muscle sympathetic fibular nerve activity in hypercholesterolemic and hypertensive patients, but not in controls. At baseline, brachial artery flow-mediated dilation was impaired in patients with hypercholesterolemia and arterial hypertension; red wine restored the dilation in the hypercholesterolemic group but not in the hypertensive group. CONCLUSIONS: Red wine elicits different metabolic, autonomic, and endothelial responses among individuals with hypercholesterolemia or arterial hypertension and healthy controls. Our findings highlight the need to consider patient characteristics when evaluating the response to red wine. |
| first_indexed | 2024-04-12T09:24:14Z |
| format | Article |
| id | doaj.art-f7f54c35e52e4e688aa850b64d06e2f8 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T09:24:14Z |
| publishDate | 2009-05-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-f7f54c35e52e4e688aa850b64d06e2f82022-12-22T03:38:32ZengElsevier EspañaClinics1807-59321980-53222009-05-0164543544210.1590/S1807-59322009000500011Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjectsAna CM AndradeFernando HY CesenaFernanda M Consolim-ColomboSilmara R CoimbraAlexandre M BenjóEduardo M KriegerProtasio Lemos da LuzOBJECTIVES: To compare the metabolic, hemodynamic, autonomic, and endothelial responses to short-term red wine consumption in subjects with hypercholesterolemia or arterial hypertension, and healthy controls. METHODS: Subjects with hypercholesterolemia (n=10) or arterial hypertension (n=9), or healthy controls (n=7) were given red wine (250 mL/night) for 15 days. Analyses were performed before and after red wine intake. RESULTS: Red wine significantly increased the plasma levels of HDL-cholesterol in the controls, but not in the other groups. The effects on hemodynamic measurements were mild, non-significantly more prominent in healthy subjects, and exhibited high interindividual variability. Across all participants, mean blood pressure decreased 7 mmHg (p <0.01) and systemic vascular resistance decreased 7% (p = 0.05). Heart rate and cardiac output did not significantly change in any group. Red wine enhanced muscle sympathetic fibular nerve activity in hypercholesterolemic and hypertensive patients, but not in controls. At baseline, brachial artery flow-mediated dilation was impaired in patients with hypercholesterolemia and arterial hypertension; red wine restored the dilation in the hypercholesterolemic group but not in the hypertensive group. CONCLUSIONS: Red wine elicits different metabolic, autonomic, and endothelial responses among individuals with hypercholesterolemia or arterial hypertension and healthy controls. Our findings highlight the need to consider patient characteristics when evaluating the response to red wine.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322009000500011AlcoholRed WineEndothelial FunctionFlow-mediated DilationSympathetic Activity |
| spellingShingle | Ana CM Andrade Fernando HY Cesena Fernanda M Consolim-Colombo Silmara R Coimbra Alexandre M Benjó Eduardo M Krieger Protasio Lemos da Luz Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects Clinics Alcohol Red Wine Endothelial Function Flow-mediated Dilation Sympathetic Activity |
| title | Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects |
| title_full | Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects |
| title_fullStr | Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects |
| title_full_unstemmed | Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects |
| title_short | Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects |
| title_sort | short term red wine consumption promotes differential effects on plasma levels of high density lipoprotein cholesterol sympathetic activity and endothelial function in hypercholesterolemic hypertensive and healthy subjects |
| topic | Alcohol Red Wine Endothelial Function Flow-mediated Dilation Sympathetic Activity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322009000500011 |
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