Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis
To assess the variation in left atrial (LA) and biventricular strain and its prognostic value in the course of suspected myocarditis, this retrospective study included 55 patients with clinically suspected myocarditis who underwent cardiac magnetic resonance (CMR) examinations at baseline and follow...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/2/457 |
| _version_ | 1797440785196515328 |
|---|---|
| author | Yan Chen Wenjing Zhao Nan Zhang Jiayi Liu Dongting Liu Zhonghua Sun Lei Xu Zhaoying Wen |
| author_facet | Yan Chen Wenjing Zhao Nan Zhang Jiayi Liu Dongting Liu Zhonghua Sun Lei Xu Zhaoying Wen |
| author_sort | Yan Chen |
| collection | DOAJ |
| description | To assess the variation in left atrial (LA) and biventricular strain and its prognostic value in the course of suspected myocarditis, this retrospective study included 55 patients with clinically suspected myocarditis who underwent cardiac magnetic resonance (CMR) examinations at baseline and follow-up periods. Cine images were used for feature tracking analysis. Paired Student’s <i>t</i> test, McNemar’s test, and Cox proportional hazard regression were used for statistical analysis. The LA total emptying fraction was the only functional index that showed a statistically significant improvement. The initial LA peak’s late negative strain rate (SRa) was the only parameter with a significant predictive power of major adverse cardiac events under univariable (hazard ratio [HR] 2.396, 95% confidence interval [CI] 1.044–5.498, <i>p</i> = 0.039) and multivariable Cox survival analysis when adjusted by LA strain parameters (HR 5.072, 95% CI 1.478–17.404, <i>p</i> = 0.010), LA strain and functional parameters (HR 7.197, 95% CI 1.679–30.846, <i>p</i> = 0.008), and LA and biventricular strain and functional parameters (HR 10.389, 95% CI 2.250–47.977, <i>p</i> = 0.003). Thus, our findings indicate that CMR strain is useful for monitoring LA and ventricular function in suspected myocarditis, that LA function may recover preceding ventricular function changes, and that LA strain may serve as an incremental tool to predict adverse outcomes. |
| first_indexed | 2024-03-09T12:13:25Z |
| format | Article |
| id | doaj.art-f7f558ddbc0245688ed455fae1b437b7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:13:25Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f7f558ddbc0245688ed455fae1b437b72023-11-30T22:50:13ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112245710.3390/jcm12020457Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected MyocarditisYan Chen0Wenjing Zhao1Nan Zhang2Jiayi Liu3Dongting Liu4Zhonghua Sun5Lei Xu6Zhaoying Wen7Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing 100029, ChinaDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing 100029, ChinaDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing 100029, ChinaDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing 100029, ChinaDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing 100029, ChinaDiscipline of Medical Radiation Science, Curtin Medical School, Curtin University, Perth 6102, AustraliaDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing 100029, ChinaDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing 100029, ChinaTo assess the variation in left atrial (LA) and biventricular strain and its prognostic value in the course of suspected myocarditis, this retrospective study included 55 patients with clinically suspected myocarditis who underwent cardiac magnetic resonance (CMR) examinations at baseline and follow-up periods. Cine images were used for feature tracking analysis. Paired Student’s <i>t</i> test, McNemar’s test, and Cox proportional hazard regression were used for statistical analysis. The LA total emptying fraction was the only functional index that showed a statistically significant improvement. The initial LA peak’s late negative strain rate (SRa) was the only parameter with a significant predictive power of major adverse cardiac events under univariable (hazard ratio [HR] 2.396, 95% confidence interval [CI] 1.044–5.498, <i>p</i> = 0.039) and multivariable Cox survival analysis when adjusted by LA strain parameters (HR 5.072, 95% CI 1.478–17.404, <i>p</i> = 0.010), LA strain and functional parameters (HR 7.197, 95% CI 1.679–30.846, <i>p</i> = 0.008), and LA and biventricular strain and functional parameters (HR 10.389, 95% CI 2.250–47.977, <i>p</i> = 0.003). Thus, our findings indicate that CMR strain is useful for monitoring LA and ventricular function in suspected myocarditis, that LA function may recover preceding ventricular function changes, and that LA strain may serve as an incremental tool to predict adverse outcomes.https://www.mdpi.com/2077-0383/12/2/457myocarditisatriumventriclemagnetic resonance imagingfeature trackingstrain |
| spellingShingle | Yan Chen Wenjing Zhao Nan Zhang Jiayi Liu Dongting Liu Zhonghua Sun Lei Xu Zhaoying Wen Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis Journal of Clinical Medicine myocarditis atrium ventricle magnetic resonance imaging feature tracking strain |
| title | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_full | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_fullStr | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_full_unstemmed | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_short | Prognostic Significance of Cardiac Magnetic Resonance in Left Atrial and Biventricular Strain Analysis during the Follow-Up of Suspected Myocarditis |
| title_sort | prognostic significance of cardiac magnetic resonance in left atrial and biventricular strain analysis during the follow up of suspected myocarditis |
| topic | myocarditis atrium ventricle magnetic resonance imaging feature tracking strain |
| url | https://www.mdpi.com/2077-0383/12/2/457 |
| work_keys_str_mv | AT yanchen prognosticsignificanceofcardiacmagneticresonanceinleftatrialandbiventricularstrainanalysisduringthefollowupofsuspectedmyocarditis AT wenjingzhao prognosticsignificanceofcardiacmagneticresonanceinleftatrialandbiventricularstrainanalysisduringthefollowupofsuspectedmyocarditis AT nanzhang prognosticsignificanceofcardiacmagneticresonanceinleftatrialandbiventricularstrainanalysisduringthefollowupofsuspectedmyocarditis AT jiayiliu prognosticsignificanceofcardiacmagneticresonanceinleftatrialandbiventricularstrainanalysisduringthefollowupofsuspectedmyocarditis AT dongtingliu prognosticsignificanceofcardiacmagneticresonanceinleftatrialandbiventricularstrainanalysisduringthefollowupofsuspectedmyocarditis AT zhonghuasun prognosticsignificanceofcardiacmagneticresonanceinleftatrialandbiventricularstrainanalysisduringthefollowupofsuspectedmyocarditis AT leixu prognosticsignificanceofcardiacmagneticresonanceinleftatrialandbiventricularstrainanalysisduringthefollowupofsuspectedmyocarditis AT zhaoyingwen prognosticsignificanceofcardiacmagneticresonanceinleftatrialandbiventricularstrainanalysisduringthefollowupofsuspectedmyocarditis |