Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique
Granules with superior fluidity and low moisture absorption are ideal for tableting and capsule filling. Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs. The objective of the present study was to develop a solvent-less a...
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| Format: | Article |
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MDPI AG
2019-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/5/198 |
| _version_ | 1811263792407904256 |
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| author | Yan Yang Nan Zheng Xiaoyue Wang Ryan Ivone Weiguang Shan Jie Shen |
| author_facet | Yan Yang Nan Zheng Xiaoyue Wang Ryan Ivone Weiguang Shan Jie Shen |
| author_sort | Yan Yang |
| collection | DOAJ |
| description | Granules with superior fluidity and low moisture absorption are ideal for tableting and capsule filling. Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs. The objective of the present study was to develop a solvent-less and high throughput melt granulation method via the melt centrifugal atomization (MCA) technique. The granule formability of various drugs and excipients via MCA and their dissolution properties were studied. It was found that the yield, fluidity, and moisture resistance of the granules were affected by the drug and excipient types, operation temperature, and collector diameter. The drugs were in an amorphous state in pure drug granules, or were highly dispersed in excipients as solid dispersions. The granules produced via MCA showed an improved drug dissolution. The present study demonstrated that the solvent-free, one-step, and high-throughput MCA approach can be used to produce spherical granules with superior fluidity and immediate drug release characteristics for poorly water-soluble and moisture-sensitive therapeutics. |
| first_indexed | 2024-04-12T19:50:26Z |
| format | Article |
| id | doaj.art-f7f5d2d1fc9e480bba87a1e0f8af2d3b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-12T19:50:26Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f7f5d2d1fc9e480bba87a1e0f8af2d3b2022-12-22T03:18:50ZengMDPI AGPharmaceutics1999-49232019-04-0111519810.3390/pharmaceutics11050198pharmaceutics11050198Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization TechniqueYan Yang0Nan Zheng1Xiaoyue Wang2Ryan Ivone3Weiguang Shan4Jie Shen5College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmacy, University of Rhode Island, Kingston, RI 02881, USACollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmacy, University of Rhode Island, Kingston, RI 02881, USAGranules with superior fluidity and low moisture absorption are ideal for tableting and capsule filling. Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs. The objective of the present study was to develop a solvent-less and high throughput melt granulation method via the melt centrifugal atomization (MCA) technique. The granule formability of various drugs and excipients via MCA and their dissolution properties were studied. It was found that the yield, fluidity, and moisture resistance of the granules were affected by the drug and excipient types, operation temperature, and collector diameter. The drugs were in an amorphous state in pure drug granules, or were highly dispersed in excipients as solid dispersions. The granules produced via MCA showed an improved drug dissolution. The present study demonstrated that the solvent-free, one-step, and high-throughput MCA approach can be used to produce spherical granules with superior fluidity and immediate drug release characteristics for poorly water-soluble and moisture-sensitive therapeutics.https://www.mdpi.com/1999-4923/11/5/198melt centrifugal atomization (MCA)spherical granulesmelt rheologyimmediate releasemoisture absorption |
| spellingShingle | Yan Yang Nan Zheng Xiaoyue Wang Ryan Ivone Weiguang Shan Jie Shen Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique Pharmaceutics melt centrifugal atomization (MCA) spherical granules melt rheology immediate release moisture absorption |
| title | Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique |
| title_full | Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique |
| title_fullStr | Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique |
| title_full_unstemmed | Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique |
| title_short | Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique |
| title_sort | rapid preparation of spherical granules via the melt centrifugal atomization technique |
| topic | melt centrifugal atomization (MCA) spherical granules melt rheology immediate release moisture absorption |
| url | https://www.mdpi.com/1999-4923/11/5/198 |
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