Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique

Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique

Granules with superior fluidity and low moisture absorption are ideal for tableting and capsule filling. Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs. The objective of the present study was to develop a solvent-less a...

Full description

Bibliographic Details
Main Authors:	Yan Yang, Nan Zheng, Xiaoyue Wang, Ryan Ivone, Weiguang Shan, Jie Shen
Format:	Article
Language:	English
Published:	MDPI AG 2019-04-01
Series:	Pharmaceutics
Subjects:	melt centrifugal atomization (MCA) spherical granules melt rheology immediate release moisture absorption
Online Access:	https://www.mdpi.com/1999-4923/11/5/198

Similar Items

Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt Granulation of Metformin Hydrochloride: Effect of Rheological Properties of Polymer on Melt Granulation and Granule Properties
by: Amol Batra, et al.
Published: (2021-12-01)

Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical properties of ascorbic acid granules
by: Valentyn Mohylyuk, et al.
Published: (2022-11-01)

Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products
by: Seth P. Forster, et al.
Published: (2021-05-01)

Melt granulation as an alternative technique in solid dosage forms manufacture
by: Aleksić Ivana, et al.
Published: (2015-01-01)

Soft-chewable paracetamol tablets by melt granulation method: Formulation and characterization
by: Awis Sukarni Mohmad Sabere, et al.
Published: (2021-01-01)

Continuous Melt Granulation for Taste-Masking of Ibuprofen
by: Seth P. Forster, et al.
Published: (2021-06-01)

Material Transport Characteristics in Planetary Roller Melt Granulation
by: Tom Lang, et al.
Published: (2023-07-01)

A versatile hot melt centrifugal spinning apparatus for thermoplastic microfibres production
by: Jason Gunther, et al.
Published: (2023-09-01)

The Impacts of Method Selectivity and Binders on the Properties of Carbamazepine Granules and Their Applications: A Case Study
by: Rahul Tatyarao Shete, et al.
Published: (2022-07-01)

Glyceryl Laurate Tablets: Effect of the Excipients and Granule Size on the Tablet Quality
by: Špaglová M., et al.
Published: (2023-08-01)

Studies on preparation of aceclofenac pellets by centrifugal granulator
by: Zibin GAO, et al.

Preparation of tin alloys spherical fine metal powders by centrifugal atomization based on mono-sized droplets
by: DONG Wei, et al.
Published: (2020-09-01)

Continuous melt granulation to develop high drug loaded sustained release tablet of Metformin HCl
by: Pradnya Vaingankar, et al.
Published: (2017-01-01)

Application of multivariate techniques in the evaluation of melt granulation products
by: Ana Teresa Ochoa Andrade
Published: (2011-12-01)

The Influence of the Polymer Type on the Quality of Newly Developed Oral Immediate-Release Tablets Containing Amiodarone Solid Dispersions Obtained by Hot-Melt Extrusion
by: Ancuța Cătălina Fița, et al.
Published: (2022-10-01)

Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms
by: Jaemin Lee, et al.
Published: (2020-08-01)

ON THE DEPENDENCIES OF THE MELTING PARAMETERS VERSUS NUMBER OF ATOMS IN THE SILICON NANOCRYSTAL
by: M.N. Magomedov
Published: (2015-11-01)

Solubility enhancement of glimperide: Development of solid dispersion by solvent melt method, characterization and dosage form development
by: Kamla Pathak, et al.
Published: (2017-05-01)

Solubility enhancement of glimperide: Development of solid dispersion by solvent melt method, characterization and dosage form development
by: Kamla Pathak, et al.
Published: (2017-12-01)

Decay of the melt stream during dispersion in granulation devices
by: Sklabinskiy Vsevolod I., et al.
Published: (2019-01-01)

Dense Pure Tungsten Fabricated by Selective Laser Melting
by: Dianzheng Wang, et al.
Published: (2017-04-01)

A new technological approach to the granulation of slag melts of ferrous metallurgy: obtaining glassy fine-grained granules of improved quality
by: David Sakhvadze, et al.
Published: (2021-11-01)

Composition-specific granulation characteristics of molten slag at improved throughput and high temperature of 1,723 K
by: Junjun Wu, et al.
Published: (2023-12-01)

Melting trajectory of the asymmetrically-heated conical thermal head for ice-melting probes
by: Yuting Ye, et al.
Published: (2024-03-01)

New Equivalent Thermal Conductivity Model for Size-Dependent Convection-Driven Melting of Spherically Encapsulated Phase Change Material
by: Feng Hou, et al.
Published: (2021-08-01)

Transient Powder Melting in SLM Using an Analytical Model with Phase Change and Spherical Symmetry in a Semi-Infinite Medium
by: Marios M. Fyrillas, et al.
Published: (2019-06-01)

Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation
by: Esther S. Bochmann, et al.
Published: (2018-08-01)

Fluidized Bed Co-Melt Granulation: New Insights in the Influence of Process Variables and Validation of Regime Map Theory
by: Jacquelina C. Lobos de Ponga, et al.
Published: (2023-09-01)

CRITERIA AND METHODS OF PRODUCTION OF AMORPHOUS MATERIALS
by: Bartlomiej JEZ, et al.
Published: (2017-06-01)

Investigation of Polyetherimide Melt-Extruded Fibers Modified by Carbon Nanoparticles
by: Elena Ivan’kova, et al.
Published: (2021-11-01)

GLASS MELTING PHENOMENA, THEIR ORDERING AND MELTING SPACE UTILISATION
by: Němec L., et al.
Published: (2013-12-01)

Predicting the melting temperature and the heat of melting of ionic liquids
by: José O. Valderrama, et al.
Published: (2021-09-01)

Nonlinear Rheology of Unentangled Polymer Melts Reinforced with High Concentration of Rigid Nanoparticles
by: Sarvestani Alireza
Published: (2010-01-01)

Formulation and Evaluation of Fenbendazole Extended-Release Extrudes Processed by Hot-Melt Extrusion
by: Gilberto S. N. Bezerra, et al.
Published: (2022-10-01)

Melt Network Reorientation and Crystallographic Preferred Orientation Development in Sheared Partially Molten Rocks
by: Cassandra Seltzer, et al.
Published: (2023-09-01)

The Role of Fluids in Melting the Continental Crust and Generating Granitoids: An Overview
by: Jiahao Li, et al.
Published: (2022-07-01)

Influence of Lithology on Reactive Melt Flow Channelization
by: M. Pec, et al.
Published: (2020-08-01)

Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing
by: Djordje Medarević, et al.
Published: (2021-12-01)

Thermodynamic metal melting bases. Foundry production and metallurgy
by: E. I. Marukovich, et al.
Published: (2020-04-01)

Melt processable homo- and copolyimides with high thermo-oxidative stability as derived from mixed thioetherdiphthalic anhydride isomers
Published: (2010-11-01)