The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery
BACKGROUND AND OBJECTIVE: Intraoperative bleeding during endoscopic sinus surgery compromises the surgeon s vision for surgery at the surgical field. Since tizanidine causes contraction of peripheral blood vessels and hypotension, which together reduce blood flow to nasal mucosa, this study was perf...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2020-03-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
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| Online Access: | http://jbums.org/article-1-8791-en.html |
| _version_ | 1818749620705034240 |
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| author | A Mahoori B Gholamveisi M Golmohammadi Sh Pashaei Khoei Sh Sane |
| author_facet | A Mahoori B Gholamveisi M Golmohammadi Sh Pashaei Khoei Sh Sane |
| author_sort | A Mahoori |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVE: Intraoperative bleeding during endoscopic sinus surgery compromises the surgeon s vision for surgery at the surgical field. Since tizanidine causes contraction of peripheral blood vessels and hypotension, which together reduce blood flow to nasal mucosa, this study was performed to evaluate the effect of oral tizanidine on the quality of vision at the surgical field during endoscopic sinus surgery.
METHODS: This double-blind clinical study was performed on 60 patients. Patients were randomly divided into two groups by computer randomization software (2.0) and received 6 mg tizanidine and placebo before the surgery. During the operation, the quality of the operation field was evaluated and scored by the surgeon based on Boezaart scale. Pain score in recovery and 6 hours after surgery and intraoperative hemodynamic parameters were assessed.
FINDINGS: The quality of the surgical field based on the Boezaart scale was significantly better in the group receiving tizanidine (p=0.04). Pain score in recovery was 2.83±1.17 in the case group and 4.53±1.56 in the control group (p=0.001). Pain score 6 hours after surgery in the case group was 3.23±1.22 and in the control group was 4.13±1.33 (p=0.008). Mean arterial blood pressure (p=0.03) and heart rate (p=0.19) during surgery were lower in the tizanidine group.
CONCLUSION: The results of the study showed that tizanidine as a perioperative medication before endoscopic sinus surgery improves the quality of vision at the surgical field and provides a better hemodynamic profile for patients. |
| first_indexed | 2024-12-18T04:06:41Z |
| format | Article |
| id | doaj.art-f7f650384ad34641b3e87abfd60f21a1 |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-12-18T04:06:41Z |
| publishDate | 2020-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-f7f650384ad34641b3e87abfd60f21a12022-12-21T21:21:35ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702020-03-01221181187The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus SurgeryA Mahoori0B Gholamveisi1M Golmohammadi2Sh Pashaei Khoei3Sh Sane4 1. Department of Anesthesiology, School of Medicine, Urmia University of Medical Sciences, Urmia, I.R.Iran 2. Department of Operating Room, Faculty of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, I.R.Iran 1. Department of Anesthesiology, School of Medicine, Urmia University of Medical Sciences, Urmia, I.R.Iran 1. Department of Anesthesiology, School of Medicine, Urmia University of Medical Sciences, Urmia, I.R.Iran 1. Department of Anesthesiology, School of Medicine, Urmia University of Medical Sciences, Urmia, I.R.Iran BACKGROUND AND OBJECTIVE: Intraoperative bleeding during endoscopic sinus surgery compromises the surgeon s vision for surgery at the surgical field. Since tizanidine causes contraction of peripheral blood vessels and hypotension, which together reduce blood flow to nasal mucosa, this study was performed to evaluate the effect of oral tizanidine on the quality of vision at the surgical field during endoscopic sinus surgery. METHODS: This double-blind clinical study was performed on 60 patients. Patients were randomly divided into two groups by computer randomization software (2.0) and received 6 mg tizanidine and placebo before the surgery. During the operation, the quality of the operation field was evaluated and scored by the surgeon based on Boezaart scale. Pain score in recovery and 6 hours after surgery and intraoperative hemodynamic parameters were assessed. FINDINGS: The quality of the surgical field based on the Boezaart scale was significantly better in the group receiving tizanidine (p=0.04). Pain score in recovery was 2.83±1.17 in the case group and 4.53±1.56 in the control group (p=0.001). Pain score 6 hours after surgery in the case group was 3.23±1.22 and in the control group was 4.13±1.33 (p=0.008). Mean arterial blood pressure (p=0.03) and heart rate (p=0.19) during surgery were lower in the tizanidine group. CONCLUSION: The results of the study showed that tizanidine as a perioperative medication before endoscopic sinus surgery improves the quality of vision at the surgical field and provides a better hemodynamic profile for patients.http://jbums.org/article-1-8791-en.htmltizanidineendoscopic sinus surgerybleedingarterial pressure. |
| spellingShingle | A Mahoori B Gholamveisi M Golmohammadi Sh Pashaei Khoei Sh Sane The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul tizanidine endoscopic sinus surgery bleeding arterial pressure. |
| title | The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_full | The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_fullStr | The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_full_unstemmed | The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_short | The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_sort | effect of oral tizanidine on bleeding and quality of surgical field during endoscopic sinus surgery |
| topic | tizanidine endoscopic sinus surgery bleeding arterial pressure. |
| url | http://jbums.org/article-1-8791-en.html |
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