Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer

Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer

Objective: Ki67 is a prognostic and predictive marker in breast cancer (BC). However, manual scoring (MS) by visual assessment suffers from high inter-observer variability which limits its clinical use. Here, we developed a new digital image analysis (DIA) workflow, named KiQuant for automated scori...

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Bibliographic Details
Main Authors: Garazi Serna, Sara Simonetti, Roberta Fasani, Francesca Pagliuca, Xavier Guardia, Paqui Gallego, Jose Jimenez, Vicente Peg, Cristina Saura, Serenella Eppenberger-Castori, Santiago Ramon y Cajal, Luigi Terracciano, Paolo Nuciforo
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Breast
Subjects:
Ki67 quantification
Breast cancer
Prognosis
Sequential immunohistochemistry
Digital image analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0960977620301442

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