The effects of oral vitamin D on insulin resistance in pre-diabetic patients
Background: Some epidemiological and interventional studies have shown the role of vitamin D on insulin secretion and resistance. A previous study in our center showed that intramuscular vitamin D decreases insulin sensitivity in pre-diabetic patients. We investigated the role of oral vitamin D on t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=1;spage=47;epage=51;aulast=Hoseini |
| _version_ | 1818532754237685760 |
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| author | Seyed A Hoseini Ashraf Aminorroaya Bijan Iraj Massoud Amini |
| author_facet | Seyed A Hoseini Ashraf Aminorroaya Bijan Iraj Massoud Amini |
| author_sort | Seyed A Hoseini |
| collection | DOAJ |
| description | Background: Some epidemiological and interventional studies have shown the role of vitamin D on insulin secretion and resistance. A previous study in our center showed that intramuscular vitamin D decreases insulin sensitivity in pre-diabetic patients. We investigated the role of oral vitamin D on the insulin sensitivity index and insulin resistance in pre-diabetic patients. Materials and Methods: In a randomized clinical trial, we divided 45 people with pre-diabetes aged 47.4 ± 6.6 (range 33-61) years into three groups: group A subjects treated with 50,000 IU oral vitamin D and 500 mg calcium carbonate (n = 21), group B subjects treated with a single 300,000 IU intramuscular vitamin D and 500 mg calcium carbonate (n = 9), and group C subjects treated with 500 mg calcium carbonate alone (n = 15). Serum 25-hydroxyvitamin D [25(OH) D] was measured at baseline. If it was less than 75 nmol/l, 50,000 IU vitamin D was given weekly, and if serum 25(OH) D was more than that, vitamin D was administered every 2 weeks. Before and after 12 weeks of treatment, a 75-g glucose tolerance test was performed. We used paired t-test and analysis of variance (ANOVA) to analyze the data. P values less than 0.05 were considered significant. Results: Mean (SD) of serum vitamin D increased from 77.5 ± 39.2 to 118.8 ± 56.3 nmol/l (P = 0.009) in group A and from 80 ± 36 to 102.8 ± 43.3 nmol/l (P = 0.053) in group B, and decreased from 44.8 ± 18.3 to 34.6 ± 13.9 nmol/l (P = 0.06) in group C. Insulin sensitivity index (Matsuda) decreased from 11.4 ± 3 to 9.9 ± 3.2 (P = 0.046) in group A, but in comparison with other groups, it was not significant. Conclusion: Oral vitamin D had no effect on insulin sensitivity in pre-diabetes patients in 12 weeks treatment. A randomized double-blind study with a longer duration of treatment is suggested to investigate the effect of vitamin D on insulin resistance. |
| first_indexed | 2024-12-11T17:49:39Z |
| format | Article |
| id | doaj.art-f7fa8dc0fe894560b4017bb82e97c616 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-11T17:49:39Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-f7fa8dc0fe894560b4017bb82e97c6162022-12-22T00:56:16ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362013-01-011814751The effects of oral vitamin D on insulin resistance in pre-diabetic patientsSeyed A HoseiniAshraf AminorroayaBijan IrajMassoud AminiBackground: Some epidemiological and interventional studies have shown the role of vitamin D on insulin secretion and resistance. A previous study in our center showed that intramuscular vitamin D decreases insulin sensitivity in pre-diabetic patients. We investigated the role of oral vitamin D on the insulin sensitivity index and insulin resistance in pre-diabetic patients. Materials and Methods: In a randomized clinical trial, we divided 45 people with pre-diabetes aged 47.4 ± 6.6 (range 33-61) years into three groups: group A subjects treated with 50,000 IU oral vitamin D and 500 mg calcium carbonate (n = 21), group B subjects treated with a single 300,000 IU intramuscular vitamin D and 500 mg calcium carbonate (n = 9), and group C subjects treated with 500 mg calcium carbonate alone (n = 15). Serum 25-hydroxyvitamin D [25(OH) D] was measured at baseline. If it was less than 75 nmol/l, 50,000 IU vitamin D was given weekly, and if serum 25(OH) D was more than that, vitamin D was administered every 2 weeks. Before and after 12 weeks of treatment, a 75-g glucose tolerance test was performed. We used paired t-test and analysis of variance (ANOVA) to analyze the data. P values less than 0.05 were considered significant. Results: Mean (SD) of serum vitamin D increased from 77.5 ± 39.2 to 118.8 ± 56.3 nmol/l (P = 0.009) in group A and from 80 ± 36 to 102.8 ± 43.3 nmol/l (P = 0.053) in group B, and decreased from 44.8 ± 18.3 to 34.6 ± 13.9 nmol/l (P = 0.06) in group C. Insulin sensitivity index (Matsuda) decreased from 11.4 ± 3 to 9.9 ± 3.2 (P = 0.046) in group A, but in comparison with other groups, it was not significant. Conclusion: Oral vitamin D had no effect on insulin sensitivity in pre-diabetes patients in 12 weeks treatment. A randomized double-blind study with a longer duration of treatment is suggested to investigate the effect of vitamin D on insulin resistance.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=1;spage=47;epage=51;aulast=HoseiniGlucose tolerance testinsulin resistancepre-diabetesvitamin Dvitamin D deficiency |
| spellingShingle | Seyed A Hoseini Ashraf Aminorroaya Bijan Iraj Massoud Amini The effects of oral vitamin D on insulin resistance in pre-diabetic patients Journal of Research in Medical Sciences Glucose tolerance test insulin resistance pre-diabetes vitamin D vitamin D deficiency |
| title | The effects of oral vitamin D on insulin resistance in pre-diabetic patients |
| title_full | The effects of oral vitamin D on insulin resistance in pre-diabetic patients |
| title_fullStr | The effects of oral vitamin D on insulin resistance in pre-diabetic patients |
| title_full_unstemmed | The effects of oral vitamin D on insulin resistance in pre-diabetic patients |
| title_short | The effects of oral vitamin D on insulin resistance in pre-diabetic patients |
| title_sort | effects of oral vitamin d on insulin resistance in pre diabetic patients |
| topic | Glucose tolerance test insulin resistance pre-diabetes vitamin D vitamin D deficiency |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=1;spage=47;epage=51;aulast=Hoseini |
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