Age and gender as determinants of the bone quality of the greater tuberosity: A HR-pQCT cadaver study
<p>Abstract</p> <p>Background</p> <p>Age-dependent trabecular changes of the humeral head might weaken the fixation of suture anchors used for rotator cuff (RC) repair. This might lead to suture anchor loosening and thus compromise the integrity of the repair. The aim o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-11-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2474/13/221 |
| _version_ | 1818755612860743680 |
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| author | Kirchhoff Chlodwig Braunstein Volker Milz Stefan Sprecher Christoph M Kirchhoff Sonja Graw Mathias Imhoff Andreas B Hinterwimmer Stefan |
| author_facet | Kirchhoff Chlodwig Braunstein Volker Milz Stefan Sprecher Christoph M Kirchhoff Sonja Graw Mathias Imhoff Andreas B Hinterwimmer Stefan |
| author_sort | Kirchhoff Chlodwig |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Age-dependent trabecular changes of the humeral head might weaken the fixation of suture anchors used for rotator cuff (RC) repair. This might lead to suture anchor loosening and thus compromise the integrity of the repair. The aim of this study was to analyze whether the trabecular microstructure within the RC footprint is influenced by age, gender or handedness.</p> <p>Methods</p> <p>Axial HR-pQCT scans (Scanco Medical) of 64 freshly frozen cadaveric human humeral head specimens (age 72.3 ± 17.4 years) were analyzed to determine the bone volume-to-total volume ratio (BV/TV), trabecular thickness (Trab Th), trabecular number (Trab N) and connectivity density (Conn Dens). Within the RC footprint, 2 volumes of interest (VOI), posteromedial (PM) and anterolateral (AL) and one control VOI in the subarticular bone (SC) were set.</p> <p>Results</p> <p>The highest BV/TV was found in SC: 0.22 ± 0.06% vs. PM: 0.04 ± 0.05% vs. AL: 0.02 ± 0.04%; p < 0.05. Trab Th accounted for 0.26 ± 0.05 μm in SC, 0.23 ± 0.09 μm in AL and 0.21 ± 0.05 μm in PM. In parallel, Trab N and Conn Dens were found to be the highest in SC. Gender analysis yielded higher values for BV/TV, Trab Th, Trab N and Conn Dens for PM in males compared to females (p < 0.05). There were no significant findings when comparing both sides. We furthermore found a strong inverse correlation between age and BV/TV, which was more pronounced in the female specimens (r = −0.72, p < 0.00001).</p> <p>Conclusions</p> <p>The presented microarchitectural data allow for future subtle biomechanical testing comprising knowledge on age- and sex-related changes of the tuberosities of the humeral head. Furthermore, the insights on the trabecular structure of the humeral head of the elderly may lead to the development of new fixation materials in bone with inferior bone quality.</p> |
| first_indexed | 2024-12-18T05:41:55Z |
| format | Article |
| id | doaj.art-f7fb902a1ece4318ae53ee7e87b88046 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-18T05:41:55Z |
| publishDate | 2012-11-01 |
| publisher | BMC |
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| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-f7fb902a1ece4318ae53ee7e87b880462022-12-21T21:19:10ZengBMCBMC Musculoskeletal Disorders1471-24742012-11-0113122110.1186/1471-2474-13-221Age and gender as determinants of the bone quality of the greater tuberosity: A HR-pQCT cadaver studyKirchhoff ChlodwigBraunstein VolkerMilz StefanSprecher Christoph MKirchhoff SonjaGraw MathiasImhoff Andreas BHinterwimmer Stefan<p>Abstract</p> <p>Background</p> <p>Age-dependent trabecular changes of the humeral head might weaken the fixation of suture anchors used for rotator cuff (RC) repair. This might lead to suture anchor loosening and thus compromise the integrity of the repair. The aim of this study was to analyze whether the trabecular microstructure within the RC footprint is influenced by age, gender or handedness.</p> <p>Methods</p> <p>Axial HR-pQCT scans (Scanco Medical) of 64 freshly frozen cadaveric human humeral head specimens (age 72.3 ± 17.4 years) were analyzed to determine the bone volume-to-total volume ratio (BV/TV), trabecular thickness (Trab Th), trabecular number (Trab N) and connectivity density (Conn Dens). Within the RC footprint, 2 volumes of interest (VOI), posteromedial (PM) and anterolateral (AL) and one control VOI in the subarticular bone (SC) were set.</p> <p>Results</p> <p>The highest BV/TV was found in SC: 0.22 ± 0.06% vs. PM: 0.04 ± 0.05% vs. AL: 0.02 ± 0.04%; p < 0.05. Trab Th accounted for 0.26 ± 0.05 μm in SC, 0.23 ± 0.09 μm in AL and 0.21 ± 0.05 μm in PM. In parallel, Trab N and Conn Dens were found to be the highest in SC. Gender analysis yielded higher values for BV/TV, Trab Th, Trab N and Conn Dens for PM in males compared to females (p < 0.05). There were no significant findings when comparing both sides. We furthermore found a strong inverse correlation between age and BV/TV, which was more pronounced in the female specimens (r = −0.72, p < 0.00001).</p> <p>Conclusions</p> <p>The presented microarchitectural data allow for future subtle biomechanical testing comprising knowledge on age- and sex-related changes of the tuberosities of the humeral head. Furthermore, the insights on the trabecular structure of the humeral head of the elderly may lead to the development of new fixation materials in bone with inferior bone quality.</p>http://www.biomedcentral.com/1471-2474/13/221AgingHumeral headMicroarchitectureRotator cuffGender |
| spellingShingle | Kirchhoff Chlodwig Braunstein Volker Milz Stefan Sprecher Christoph M Kirchhoff Sonja Graw Mathias Imhoff Andreas B Hinterwimmer Stefan Age and gender as determinants of the bone quality of the greater tuberosity: A HR-pQCT cadaver study BMC Musculoskeletal Disorders Aging Humeral head Microarchitecture Rotator cuff Gender |
| title | Age and gender as determinants of the bone quality of the greater tuberosity: A HR-pQCT cadaver study |
| title_full | Age and gender as determinants of the bone quality of the greater tuberosity: A HR-pQCT cadaver study |
| title_fullStr | Age and gender as determinants of the bone quality of the greater tuberosity: A HR-pQCT cadaver study |
| title_full_unstemmed | Age and gender as determinants of the bone quality of the greater tuberosity: A HR-pQCT cadaver study |
| title_short | Age and gender as determinants of the bone quality of the greater tuberosity: A HR-pQCT cadaver study |
| title_sort | age and gender as determinants of the bone quality of the greater tuberosity a hr pqct cadaver study |
| topic | Aging Humeral head Microarchitecture Rotator cuff Gender |
| url | http://www.biomedcentral.com/1471-2474/13/221 |
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