Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium

Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium

Objectives Programmed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5− T cells, termed T peripheral helper (Tph) cells, which drive B cell differentiation, have been identified in ec...

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Main Authors: Susanna M Proudman, Ling-Yang Hao, William Murray-Brown, Helen Weedon, Malcolm D Smith, Mihir D Wechalekar, Susan E Lester, Sunil Nagpal, Yanxia Guo, Annabelle Small, Katie Lowe, Navin L Rao
Format: Article
Language:English
Published: BMJ Publishing Group 2022-10-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/8/2/e002563.full

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