Glomerular Filtration Rate Assessment in Children
Glomerular filtration rate (GFR) measurement is a key tool for determining the degree of chronic kidney disease. The assessment of GFR is even more challenging in children than in adults with more variables in the equation than race and sex. Monitoring the progress of the kidney disease can therefor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/12/1995 |
| _version_ | 1827641292875628544 |
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| author | Sonja Golob Jančič Mirjam Močnik Nataša Marčun Varda |
| author_facet | Sonja Golob Jančič Mirjam Močnik Nataša Marčun Varda |
| author_sort | Sonja Golob Jančič |
| collection | DOAJ |
| description | Glomerular filtration rate (GFR) measurement is a key tool for determining the degree of chronic kidney disease. The assessment of GFR is even more challenging in children than in adults with more variables in the equation than race and sex. Monitoring the progress of the kidney disease can therefore be difficult as in the initial stages of a decline in kidney function, there are no clinical signs. Due to children’s growth and development, changes in muscle mass and growth impair GFR estimation based solely on serum creatinine values. More invasive methods of GFR measurement are more reliable, but techniques using ionising agents, requiring large volume blood samples or timed voiding, have limited application in children. This paper reviews the methods of measuring and determining glomerular filtration rate and kidney function in children. |
| first_indexed | 2024-03-09T17:11:56Z |
| format | Article |
| id | doaj.art-f7ff7808808c481e93f4f2f32156833d |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T17:11:56Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-f7ff7808808c481e93f4f2f32156833d2023-11-24T14:03:14ZengMDPI AGChildren2227-90672022-12-01912199510.3390/children9121995Glomerular Filtration Rate Assessment in ChildrenSonja Golob Jančič0Mirjam Močnik1Nataša Marčun Varda2Department of Paediatrics, University Medical Centre Maribor, Ljubljanska 5, 2000 Maribor, SloveniaDepartment of Paediatrics, University Medical Centre Maribor, Ljubljanska 5, 2000 Maribor, SloveniaDepartment of Paediatrics, University Medical Centre Maribor, Ljubljanska 5, 2000 Maribor, SloveniaGlomerular filtration rate (GFR) measurement is a key tool for determining the degree of chronic kidney disease. The assessment of GFR is even more challenging in children than in adults with more variables in the equation than race and sex. Monitoring the progress of the kidney disease can therefore be difficult as in the initial stages of a decline in kidney function, there are no clinical signs. Due to children’s growth and development, changes in muscle mass and growth impair GFR estimation based solely on serum creatinine values. More invasive methods of GFR measurement are more reliable, but techniques using ionising agents, requiring large volume blood samples or timed voiding, have limited application in children. This paper reviews the methods of measuring and determining glomerular filtration rate and kidney function in children.https://www.mdpi.com/2227-9067/9/12/1995glomerular filtration rateassessmentchildrenchronic kidney disease |
| spellingShingle | Sonja Golob Jančič Mirjam Močnik Nataša Marčun Varda Glomerular Filtration Rate Assessment in Children Children glomerular filtration rate assessment children chronic kidney disease |
| title | Glomerular Filtration Rate Assessment in Children |
| title_full | Glomerular Filtration Rate Assessment in Children |
| title_fullStr | Glomerular Filtration Rate Assessment in Children |
| title_full_unstemmed | Glomerular Filtration Rate Assessment in Children |
| title_short | Glomerular Filtration Rate Assessment in Children |
| title_sort | glomerular filtration rate assessment in children |
| topic | glomerular filtration rate assessment children chronic kidney disease |
| url | https://www.mdpi.com/2227-9067/9/12/1995 |
| work_keys_str_mv | AT sonjagolobjancic glomerularfiltrationrateassessmentinchildren AT mirjammocnik glomerularfiltrationrateassessmentinchildren AT natasamarcunvarda glomerularfiltrationrateassessmentinchildren |