RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis
BackgroundShorter telomere length is associated with numerous comorbidities. Several studies have investigated the role of obesity in telomere shortening. In the current systematic review and meta-analysis, we summarized the results of studies that evaluated the association between obesity and telom...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.812846/full |
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| author | Sheida Khosravaniardakani Dmitry Olegovich Bokov Dmitry Olegovich Bokov Trias Mahmudiono Seyedeh Sedigheh Hashemi Negin Nikrad Shadi Rabieemotmaen Mahdieh Abbasalizad-Farhangi |
| author_facet | Sheida Khosravaniardakani Dmitry Olegovich Bokov Dmitry Olegovich Bokov Trias Mahmudiono Seyedeh Sedigheh Hashemi Negin Nikrad Shadi Rabieemotmaen Mahdieh Abbasalizad-Farhangi |
| author_sort | Sheida Khosravaniardakani |
| collection | DOAJ |
| description | BackgroundShorter telomere length is associated with numerous comorbidities. Several studies have investigated the role of obesity in telomere shortening. In the current systematic review and meta-analysis, we summarized the results of studies that evaluated the association between obesity and telomere length.MethodsA systematic search from Scopus, PubMed, Embase, and ProQuest electronic databases up to 19 March 2021 without language restriction was performed and after data extraction and screening, 19 manuscripts were eligible to be included in the final meta-synthesis.ResultsThe highest category of telomere length was associated with an approximate 0.75 kg/m2 reduction in body mass index (BMI; WMD = −0.75 kg/m2; CI = −1.19, −0.31; p < 0.001; I2 = 99.4%). Moreover, overweight/obese individuals had 0.036 kbp shorter telomere length compared with non-overweight/obese adults (WMD = −0.036; CI = −0.05, −0.02; p = 0.030; I2 = 100%). According to the results of subgroupings, continent, age, and sample size could be possible sources of heterogeneity.ConclusionFrom the results, it was clear that obesity was associated with shorter telomere length. Because of the observational design of included studies, the causality inference of results should be done with caution; thus, further longitudinal studies are warranted for better inference of causal association. |
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| language | English |
| last_indexed | 2024-04-24T19:27:12Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-f7ff7c3e8a7e4046a537ad475876628b2024-03-25T15:31:38ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-05-01910.3389/fnut.2022.812846812846RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-AnalysisSheida Khosravaniardakani0Dmitry Olegovich Bokov1Dmitry Olegovich Bokov2Trias Mahmudiono3Seyedeh Sedigheh Hashemi4Negin Nikrad5Shadi Rabieemotmaen6Mahdieh Abbasalizad-Farhangi7Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IranInstitute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, RussiaLaboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, RussiaDepartment of Nutrition, Faculty of Public Health, Universitas Airlangga, Surabaya, IndonesiaDepartment of Nutrition, School of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, IranStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Biology, East Tehran Branch, Islamic Azad University, Tehran, IranDepartment of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IranBackgroundShorter telomere length is associated with numerous comorbidities. Several studies have investigated the role of obesity in telomere shortening. In the current systematic review and meta-analysis, we summarized the results of studies that evaluated the association between obesity and telomere length.MethodsA systematic search from Scopus, PubMed, Embase, and ProQuest electronic databases up to 19 March 2021 without language restriction was performed and after data extraction and screening, 19 manuscripts were eligible to be included in the final meta-synthesis.ResultsThe highest category of telomere length was associated with an approximate 0.75 kg/m2 reduction in body mass index (BMI; WMD = −0.75 kg/m2; CI = −1.19, −0.31; p < 0.001; I2 = 99.4%). Moreover, overweight/obese individuals had 0.036 kbp shorter telomere length compared with non-overweight/obese adults (WMD = −0.036; CI = −0.05, −0.02; p = 0.030; I2 = 100%). According to the results of subgroupings, continent, age, and sample size could be possible sources of heterogeneity.ConclusionFrom the results, it was clear that obesity was associated with shorter telomere length. Because of the observational design of included studies, the causality inference of results should be done with caution; thus, further longitudinal studies are warranted for better inference of causal association.https://www.frontiersin.org/articles/10.3389/fnut.2022.812846/fulltelomere lengthobesitysystematic literature searchmeta-analysis of hypothesisadult |
| spellingShingle | Sheida Khosravaniardakani Dmitry Olegovich Bokov Dmitry Olegovich Bokov Trias Mahmudiono Seyedeh Sedigheh Hashemi Negin Nikrad Shadi Rabieemotmaen Mahdieh Abbasalizad-Farhangi RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis Frontiers in Nutrition telomere length obesity systematic literature search meta-analysis of hypothesis adult |
| title | RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis |
| title_full | RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis |
| title_fullStr | RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis |
| title_full_unstemmed | RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis |
| title_short | RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis |
| title_sort | retracted obesity accelerates leukocyte telomere length shortening in apparently healthy adults a meta analysis |
| topic | telomere length obesity systematic literature search meta-analysis of hypothesis adult |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.812846/full |
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