Impact of <i>Enterococci</i> vs. <i>Staphylococci</i> Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation
Background: The two most common organisms found in infective endocarditis following transcatheter aortic valve implantation (TAVI-IE) are <i>enterococci</i> (EC-IE) and <i>staphylococci</i> (SC-IE). We aimed to compare clinical characteristics and outcomes of patients with EC...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1817 |
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| author | Tomasz Gasior Felix J. Woitek Antonia Schroth Mohamed Abdel-Wahab Lisa Crusius Stephan Haussig Philipp Kiefer Piotr Scislo Zenon Huczek Maciej Dabrowski Adam Witkowski Anna Olasinska-Wisniewska Marek Grygier Marcin Protasiewicz Damian Hudziak Utz Kappert David Holzhey Wojtek Wojakowski Axel Linke Norman Mangner |
| author_facet | Tomasz Gasior Felix J. Woitek Antonia Schroth Mohamed Abdel-Wahab Lisa Crusius Stephan Haussig Philipp Kiefer Piotr Scislo Zenon Huczek Maciej Dabrowski Adam Witkowski Anna Olasinska-Wisniewska Marek Grygier Marcin Protasiewicz Damian Hudziak Utz Kappert David Holzhey Wojtek Wojakowski Axel Linke Norman Mangner |
| author_sort | Tomasz Gasior |
| collection | DOAJ |
| description | Background: The two most common organisms found in infective endocarditis following transcatheter aortic valve implantation (TAVI-IE) are <i>enterococci</i> (EC-IE) and <i>staphylococci</i> (SC-IE). We aimed to compare clinical characteristics and outcomes of patients with EC-IE and SC-IE. Methods: TAVI-IE patients from 2007 to 2021 were included in this analysis. The 1-year mortality was the primary outcome measure of this retrospective multi-center analysis. Results: Out of 163 patients, 53 (32.5%) EC-IE and 69 (42.3%) SC-IE patients were included. Subjects were comparable with regard to age, sex, and clinically relevant baseline comorbidities. Symptoms at admission were not significantly different between groups, except for a lower risk for presenting with septic shock in EC-IE than SC-IE. Treatment was performed in 78% by antibiotics alone and in 22% of patients by surgery and antibiotics, with no significant differences between groups. The rate of any complication, in particular heart failure, renal failure, and septic shock during treatment for IE, was lower in EC-IE compared with SC-IE (<i>p</i> < 0.05). In-hospital (EC-IE: 36% vs. SC-IE: 56%, <i>p</i> = 0.035) and 1-year mortality (EC-IE: 51% vs. SC-IE: 70%, <i>p</i> = 0.009) were significantly lower in EC-IE compared with SC-IE. Conclusions: EC-IE, compared with SC-IE, was associated with a lower morbidity and mortality. However, absolute numbers are high, a finding that should trigger further research in appropriate perioperative antibiotic management and improvement of early IE diagnosis in the case of clinical suspicion. |
| first_indexed | 2024-03-11T07:21:06Z |
| format | Article |
| id | doaj.art-f8004f7e41924833aebde175775836f3 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T07:21:06Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f8004f7e41924833aebde175775836f32023-11-17T07:58:44ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125181710.3390/jcm12051817Impact of <i>Enterococci</i> vs. <i>Staphylococci</i> Induced Infective Endocarditis after Transcatheter Aortic Valve ImplantationTomasz Gasior0Felix J. Woitek1Antonia Schroth2Mohamed Abdel-Wahab3Lisa Crusius4Stephan Haussig5Philipp Kiefer6Piotr Scislo7Zenon Huczek8Maciej Dabrowski9Adam Witkowski10Anna Olasinska-Wisniewska11Marek Grygier12Marcin Protasiewicz13Damian Hudziak14Utz Kappert15David Holzhey16Wojtek Wojakowski17Axel Linke18Norman Mangner19Department of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Cardiology, Heart Center Leipzig, University Hospital, 04289 Leipzig, GermanyDepartment of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Cardiac Surgery, Heart Center Leipzig, University Hospital, 04289 Leipzig, Germany1st Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, Poland1st Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Interventional Cardiology and Angiology, National Institute of Cardiology, 04-628 Warsaw, PolandDepartment of Interventional Cardiology and Angiology, National Institute of Cardiology, 04-628 Warsaw, PolandDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-701 Poznan, Poland1st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandInstitute of Heart Diseases, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, PolandDepartment of Cardiac Surgery, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Cardiac Surgery, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Cardiac Surgery, Helios University Hospital Wuppertal, 42117 Wuppertal, GermanyDepartment of Cardiology and Structural Heart Diseases, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, GermanyBackground: The two most common organisms found in infective endocarditis following transcatheter aortic valve implantation (TAVI-IE) are <i>enterococci</i> (EC-IE) and <i>staphylococci</i> (SC-IE). We aimed to compare clinical characteristics and outcomes of patients with EC-IE and SC-IE. Methods: TAVI-IE patients from 2007 to 2021 were included in this analysis. The 1-year mortality was the primary outcome measure of this retrospective multi-center analysis. Results: Out of 163 patients, 53 (32.5%) EC-IE and 69 (42.3%) SC-IE patients were included. Subjects were comparable with regard to age, sex, and clinically relevant baseline comorbidities. Symptoms at admission were not significantly different between groups, except for a lower risk for presenting with septic shock in EC-IE than SC-IE. Treatment was performed in 78% by antibiotics alone and in 22% of patients by surgery and antibiotics, with no significant differences between groups. The rate of any complication, in particular heart failure, renal failure, and septic shock during treatment for IE, was lower in EC-IE compared with SC-IE (<i>p</i> < 0.05). In-hospital (EC-IE: 36% vs. SC-IE: 56%, <i>p</i> = 0.035) and 1-year mortality (EC-IE: 51% vs. SC-IE: 70%, <i>p</i> = 0.009) were significantly lower in EC-IE compared with SC-IE. Conclusions: EC-IE, compared with SC-IE, was associated with a lower morbidity and mortality. However, absolute numbers are high, a finding that should trigger further research in appropriate perioperative antibiotic management and improvement of early IE diagnosis in the case of clinical suspicion.https://www.mdpi.com/2077-0383/12/5/1817TAVIinfective endocarditisstaphylococcienterococciprosthetic valve |
| spellingShingle | Tomasz Gasior Felix J. Woitek Antonia Schroth Mohamed Abdel-Wahab Lisa Crusius Stephan Haussig Philipp Kiefer Piotr Scislo Zenon Huczek Maciej Dabrowski Adam Witkowski Anna Olasinska-Wisniewska Marek Grygier Marcin Protasiewicz Damian Hudziak Utz Kappert David Holzhey Wojtek Wojakowski Axel Linke Norman Mangner Impact of <i>Enterococci</i> vs. <i>Staphylococci</i> Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation Journal of Clinical Medicine TAVI infective endocarditis staphylococci enterococci prosthetic valve |
| title | Impact of <i>Enterococci</i> vs. <i>Staphylococci</i> Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
| title_full | Impact of <i>Enterococci</i> vs. <i>Staphylococci</i> Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
| title_fullStr | Impact of <i>Enterococci</i> vs. <i>Staphylococci</i> Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
| title_full_unstemmed | Impact of <i>Enterococci</i> vs. <i>Staphylococci</i> Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
| title_short | Impact of <i>Enterococci</i> vs. <i>Staphylococci</i> Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
| title_sort | impact of i enterococci i vs i staphylococci i induced infective endocarditis after transcatheter aortic valve implantation |
| topic | TAVI infective endocarditis staphylococci enterococci prosthetic valve |
| url | https://www.mdpi.com/2077-0383/12/5/1817 |
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