Insights on the Association between Thyroid Diseases and Colorectal Cancer
Benign and malignant thyroid diseases (TDs) have been associated with the occurrence of extrathyroidal malignancies (EMs), including colorectal cancers (CRCs). Such associations have generated a major interest, as their characterization may provide useful clues regarding diseases’ etiology and/or pr...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/6/2234 |
| _version_ | 1797611067583496192 |
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| author | Federica Gagliardi Enke Baldini Eleonora Lori Silvia Cardarelli Daniele Pironi Augusto Lauro Domenico Tripodi Piergaspare Palumbo Eleonora D’Armiento Giuseppe Cavallaro Andrea Polistena Valerio D’Orazi Simone Sibio Poupak Fallahi Alessandro Antonelli Vito D’Andrea Salvatore Ulisse Salvatore Sorrenti |
| author_facet | Federica Gagliardi Enke Baldini Eleonora Lori Silvia Cardarelli Daniele Pironi Augusto Lauro Domenico Tripodi Piergaspare Palumbo Eleonora D’Armiento Giuseppe Cavallaro Andrea Polistena Valerio D’Orazi Simone Sibio Poupak Fallahi Alessandro Antonelli Vito D’Andrea Salvatore Ulisse Salvatore Sorrenti |
| author_sort | Federica Gagliardi |
| collection | DOAJ |
| description | Benign and malignant thyroid diseases (TDs) have been associated with the occurrence of extrathyroidal malignancies (EMs), including colorectal cancers (CRCs). Such associations have generated a major interest, as their characterization may provide useful clues regarding diseases’ etiology and/or progression, with the possible identification of shared congenital and environmental elements. On the other hand, elucidation of the underlying molecular mechanism(s) could lead to an improved and tailored clinical management of these patients and stimulate an increased surveillance of TD patients at higher threat of developing EMs. Here, we will examine the epidemiological, clinical, and molecular findings connecting TD and CRC, with the aim to identify possible molecular mechanism(s) responsible for such diseases’ relationship. |
| first_indexed | 2024-03-11T06:22:39Z |
| format | Article |
| id | doaj.art-f801b0289479458996a65021bcca53dc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:22:39Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f801b0289479458996a65021bcca53dc2023-11-17T11:49:57ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126223410.3390/jcm12062234Insights on the Association between Thyroid Diseases and Colorectal CancerFederica Gagliardi0Enke Baldini1Eleonora Lori2Silvia Cardarelli3Daniele Pironi4Augusto Lauro5Domenico Tripodi6Piergaspare Palumbo7Eleonora D’Armiento8Giuseppe Cavallaro9Andrea Polistena10Valerio D’Orazi11Simone Sibio12Poupak Fallahi13Alessandro Antonelli14Vito D’Andrea15Salvatore Ulisse16Salvatore Sorrenti17Department of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Specialties, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, ItalyDepartment of Surgical, Medical and Molecular Pathology and of Critical Area, University of Pisa, 56126 Pisa, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgery, “Sapienza” University of Rome, 00161 Rome, ItalyBenign and malignant thyroid diseases (TDs) have been associated with the occurrence of extrathyroidal malignancies (EMs), including colorectal cancers (CRCs). Such associations have generated a major interest, as their characterization may provide useful clues regarding diseases’ etiology and/or progression, with the possible identification of shared congenital and environmental elements. On the other hand, elucidation of the underlying molecular mechanism(s) could lead to an improved and tailored clinical management of these patients and stimulate an increased surveillance of TD patients at higher threat of developing EMs. Here, we will examine the epidemiological, clinical, and molecular findings connecting TD and CRC, with the aim to identify possible molecular mechanism(s) responsible for such diseases’ relationship.https://www.mdpi.com/2077-0383/12/6/2234thyroidhypothyroidismhyperthyroidismcolorectal cancer |
| spellingShingle | Federica Gagliardi Enke Baldini Eleonora Lori Silvia Cardarelli Daniele Pironi Augusto Lauro Domenico Tripodi Piergaspare Palumbo Eleonora D’Armiento Giuseppe Cavallaro Andrea Polistena Valerio D’Orazi Simone Sibio Poupak Fallahi Alessandro Antonelli Vito D’Andrea Salvatore Ulisse Salvatore Sorrenti Insights on the Association between Thyroid Diseases and Colorectal Cancer Journal of Clinical Medicine thyroid hypothyroidism hyperthyroidism colorectal cancer |
| title | Insights on the Association between Thyroid Diseases and Colorectal Cancer |
| title_full | Insights on the Association between Thyroid Diseases and Colorectal Cancer |
| title_fullStr | Insights on the Association between Thyroid Diseases and Colorectal Cancer |
| title_full_unstemmed | Insights on the Association between Thyroid Diseases and Colorectal Cancer |
| title_short | Insights on the Association between Thyroid Diseases and Colorectal Cancer |
| title_sort | insights on the association between thyroid diseases and colorectal cancer |
| topic | thyroid hypothyroidism hyperthyroidism colorectal cancer |
| url | https://www.mdpi.com/2077-0383/12/6/2234 |
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