Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western diet
Background: Brain-derived neurotrophic factor (BDNF) -tropomyosin-related kinase receptor B (TrkB) signaling is a vital regulator of myocardial performance. Here, we tested the impact of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on heart function, meta...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906722000719 |
| _version_ | 1818007620542267392 |
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| author | Abdulbaset Maroofi Ahmadreza Bagheri Rouch Nasim Naderi Arsalan Damirchi |
| author_facet | Abdulbaset Maroofi Ahmadreza Bagheri Rouch Nasim Naderi Arsalan Damirchi |
| author_sort | Abdulbaset Maroofi |
| collection | DOAJ |
| description | Background: Brain-derived neurotrophic factor (BDNF) -tropomyosin-related kinase receptor B (TrkB) signaling is a vital regulator of myocardial performance. Here, we tested the impact of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on heart function, metabolic parameters, and serum/cardiac BDNF (with its TrkB receptor) in animals fed a Western (WD) or regular diet (ND). Further, myocardial expression of pro-inflammatory cytokine interleukin-18 (IL-18) and cardioprotective molecule heme oxygens-1 (HO-1) were monitored. Methods: Wistar rats were divided into HIIT, MICT, and sedentary (SED), all fed a WD or ND, for 12 weeks. Heart function, protein expression, and serum factors were assessed via echocardiography, western blotting, and ELISA, respectively. Results: WD plus SED caused insulin resistance, dyslipidemia, visceral fat deposition, serum BDNF depletion as well as cardiac upregulation of IL-18 and downregulation of HO-1, without affecting, heart function and BDNF-TrkB expression. The cardiometabolic risk factors, serum BDNF losses, and IL-18 overexpression were similarly obviated by HIIT and MICT, although HO-1 expression was boosted by HIIT exclusively (even in ND). HIIT enhanced heart function, regardless of the diet. HIIT augmented cardiac BDNF expression, with a significant difference between ND and WD. Likewise, HIIT instigated TrkB expression only in ND. Conclusions: HIIT and MICT can cope with myocardial inflammation and cardiometabolic risk factors in WD consumers and, exclusively, HIIT may grant further protection by increasing heart function, BDNF-TrkB expression, and HO-1 expression. Thus, the HIIT paradigm should be considered as a preference for subjects who require heart function to be preserved or enhanced. |
| first_indexed | 2024-04-14T05:18:01Z |
| format | Article |
| id | doaj.art-f801b97efe9040cea7f3e115c6b2fba3 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-14T05:18:01Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-f801b97efe9040cea7f3e115c6b2fba32022-12-22T02:10:19ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672022-06-0140101022Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western dietAbdulbaset Maroofi0Ahmadreza Bagheri Rouch1Nasim Naderi2Arsalan Damirchi3Department of Exercise Physiology, Faculty of Physical Education & Sport Sciences, University of Guilan, Rasht, IranDepartment of Exercise Physiology, Faculty of Physical Education & Sport Sciences, University of Guilan, Rasht, IranRajaie Cardiovascular, Medical & Research Center, Iran University of Medical Sciences, Tehran, IranDepartment of Exercise Physiology, Faculty of Physical Education & Sport Sciences, University of Guilan, Rasht, Iran; Corresponding author at: Department of Exercise Physiology, Faculty of Physical Education & Sport Sciences, University of Guilan, Rasht, Iran.Background: Brain-derived neurotrophic factor (BDNF) -tropomyosin-related kinase receptor B (TrkB) signaling is a vital regulator of myocardial performance. Here, we tested the impact of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on heart function, metabolic parameters, and serum/cardiac BDNF (with its TrkB receptor) in animals fed a Western (WD) or regular diet (ND). Further, myocardial expression of pro-inflammatory cytokine interleukin-18 (IL-18) and cardioprotective molecule heme oxygens-1 (HO-1) were monitored. Methods: Wistar rats were divided into HIIT, MICT, and sedentary (SED), all fed a WD or ND, for 12 weeks. Heart function, protein expression, and serum factors were assessed via echocardiography, western blotting, and ELISA, respectively. Results: WD plus SED caused insulin resistance, dyslipidemia, visceral fat deposition, serum BDNF depletion as well as cardiac upregulation of IL-18 and downregulation of HO-1, without affecting, heart function and BDNF-TrkB expression. The cardiometabolic risk factors, serum BDNF losses, and IL-18 overexpression were similarly obviated by HIIT and MICT, although HO-1 expression was boosted by HIIT exclusively (even in ND). HIIT enhanced heart function, regardless of the diet. HIIT augmented cardiac BDNF expression, with a significant difference between ND and WD. Likewise, HIIT instigated TrkB expression only in ND. Conclusions: HIIT and MICT can cope with myocardial inflammation and cardiometabolic risk factors in WD consumers and, exclusively, HIIT may grant further protection by increasing heart function, BDNF-TrkB expression, and HO-1 expression. Thus, the HIIT paradigm should be considered as a preference for subjects who require heart function to be preserved or enhanced.http://www.sciencedirect.com/science/article/pii/S2352906722000719Brain-derived neurotrophic factor (BDNF)Receptor, trkBCardiac functionWestern dietary patternExerciseHeme oxygense-1 |
| spellingShingle | Abdulbaset Maroofi Ahmadreza Bagheri Rouch Nasim Naderi Arsalan Damirchi Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western diet International Journal of Cardiology: Heart & Vasculature Brain-derived neurotrophic factor (BDNF) Receptor, trkB Cardiac function Western dietary pattern Exercise Heme oxygense-1 |
| title | Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western diet |
| title_full | Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western diet |
| title_fullStr | Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western diet |
| title_full_unstemmed | Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western diet |
| title_short | Effects of two different exercise paradigms on cardiac function, BDNF-TrkB expression, and myocardial protection in the presence and absence of Western diet |
| title_sort | effects of two different exercise paradigms on cardiac function bdnf trkb expression and myocardial protection in the presence and absence of western diet |
| topic | Brain-derived neurotrophic factor (BDNF) Receptor, trkB Cardiac function Western dietary pattern Exercise Heme oxygense-1 |
| url | http://www.sciencedirect.com/science/article/pii/S2352906722000719 |
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