The Potential of Usnic-Acid-Based Thiazolo-Thiophenes as Inhibitors of the Main Protease of SARS-CoV-2 Viruses

The Potential of Usnic-Acid-Based Thiazolo-Thiophenes as Inhibitors of the Main Protease of SARS-CoV-2 Viruses

Although the COVID-19 pandemic caused by SARS-CoV-2 viruses is officially over, the search for new effective agents with activity against a wide range of coronaviruses is still an important task for medical chemists and virologists. We synthesized a series of thiazolo-thiophenes based on (+)- and (−...

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Bibliographic Details
Main Authors: Olga I. Yarovaya, Aleksandr S. Filimonov, Dmitriy S. Baev, Sophia S. Borisevich, Anna V. Zaykovskaya, Varvara Yu. Chirkova, Mariya K. Marenina, Yulia V. Meshkova, Svetlana V. Belenkaya, Dmitriy N. Shcherbakov, Maxim A. Gureev, Olga A. Luzina, Oleg V. Pyankov, Nariman F. Salakhutdinov, Mikhail V. Khvostov
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Viruses
Subjects:
usnic acid
SARS-CoV-2
main protease
3CL<sup>pro</sup>
molecular modeling
Online Access:https://www.mdpi.com/1999-4915/16/2/215

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