Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly
The underlying mechanism in both cognitive impairment and depression was chronic inflammation, which could be reflected by the dietary inflammatory index (DII). However, the effect of cognitive impairment on the association between DII and depression was not clear. Therefore, in this study, we hypot...
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/23/5118 |
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| author | Mengzi Sun Ling Wang Yueyang Hu Xuhan Wang Shoumeng Yan Yinpei Guo Jing Li Zechun Xie Bo Li |
| author_facet | Mengzi Sun Ling Wang Yueyang Hu Xuhan Wang Shoumeng Yan Yinpei Guo Jing Li Zechun Xie Bo Li |
| author_sort | Mengzi Sun |
| collection | DOAJ |
| description | The underlying mechanism in both cognitive impairment and depression was chronic inflammation, which could be reflected by the dietary inflammatory index (DII). However, the effect of cognitive impairment on the association between DII and depression was not clear. Therefore, in this study, we hypothesized that cognitive impairment could mediate the association between dietary inflammation and depressive symptoms. A total of 2550 participants aged ≥60 from the National Health and Nutrition Examination Survey (NHANES) in 2011–2014 were involved in the serial, cross-sectional study. Proinflammatory and anti-inflammatory diets were measured by DII. Cognitive impairment was measured by four dimensions, CERAD-immediate, CERAN-delayed, animal fluency test, and DSST. Depressive symptoms were measured by PHQ-9 scores. We found that a proinflammatory diet and cognitive impairment were both risk factors for depressive symptoms. An interaction between an inflammatory diet and cognitive impairment was detected (<i>P</i>-interaction = 0.060). In addition, all four dimensions of cognition mediated the association between DII and depressive symptom scores. Part of the association between DII and depressive symptoms scores could be explained by different dimensions of cognitive function, and the proportion of mediation ranged from 10.0% to 36.7%. In conclusion, cognitive impairment levels partly mediated the association between DII and depressive symptoms. |
| first_indexed | 2024-03-09T17:37:18Z |
| format | Article |
| id | doaj.art-f804902604824460826e3cfc4cc2d192 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T17:37:18Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f804902604824460826e3cfc4cc2d1922023-11-24T11:52:28ZengMDPI AGNutrients2072-66432022-12-011423511810.3390/nu14235118Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the ElderlyMengzi Sun0Ling Wang1Yueyang Hu2Xuhan Wang3Shoumeng Yan4Yinpei Guo5Jing Li6Zechun Xie7Bo Li8Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaDepartment of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun 130012, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaSchool of Nursing, Jilin University, Changchun 130021, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, ChinaThe underlying mechanism in both cognitive impairment and depression was chronic inflammation, which could be reflected by the dietary inflammatory index (DII). However, the effect of cognitive impairment on the association between DII and depression was not clear. Therefore, in this study, we hypothesized that cognitive impairment could mediate the association between dietary inflammation and depressive symptoms. A total of 2550 participants aged ≥60 from the National Health and Nutrition Examination Survey (NHANES) in 2011–2014 were involved in the serial, cross-sectional study. Proinflammatory and anti-inflammatory diets were measured by DII. Cognitive impairment was measured by four dimensions, CERAD-immediate, CERAN-delayed, animal fluency test, and DSST. Depressive symptoms were measured by PHQ-9 scores. We found that a proinflammatory diet and cognitive impairment were both risk factors for depressive symptoms. An interaction between an inflammatory diet and cognitive impairment was detected (<i>P</i>-interaction = 0.060). In addition, all four dimensions of cognition mediated the association between DII and depressive symptom scores. Part of the association between DII and depressive symptoms scores could be explained by different dimensions of cognitive function, and the proportion of mediation ranged from 10.0% to 36.7%. In conclusion, cognitive impairment levels partly mediated the association between DII and depressive symptoms.https://www.mdpi.com/2072-6643/14/23/5118cognitive functiondietary inflammatory indexdepressive symptomsmediation |
| spellingShingle | Mengzi Sun Ling Wang Yueyang Hu Xuhan Wang Shoumeng Yan Yinpei Guo Jing Li Zechun Xie Bo Li Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly Nutrients cognitive function dietary inflammatory index depressive symptoms mediation |
| title | Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly |
| title_full | Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly |
| title_fullStr | Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly |
| title_full_unstemmed | Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly |
| title_short | Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly |
| title_sort | cognitive impairment mediates the association between dietary inflammation and depressive symptoms in the elderly |
| topic | cognitive function dietary inflammatory index depressive symptoms mediation |
| url | https://www.mdpi.com/2072-6643/14/23/5118 |
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