Differences between primary peritoneal serous carcinoma and advanced serous ovarian carcinoma: a study based on the SEER database
Abstract Objective This study aimed to compare clinical features and overall survival (OS) between patients with primary peritoneal serous carcinoma (PPSC) and those with advanced serous ovarian carcinoma (ASOC) and to identify prognostic factors. Methods Patients diagnosed with PPSC and ASOC from 2...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-021-00788-y |
| _version_ | 1797965455567093760 |
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| author | Xiaoduo Li Qiao Yang Mingjing Chen Changqing Yang Jianfen Gu Qiang Dong Guangrong Yang |
| author_facet | Xiaoduo Li Qiao Yang Mingjing Chen Changqing Yang Jianfen Gu Qiang Dong Guangrong Yang |
| author_sort | Xiaoduo Li |
| collection | DOAJ |
| description | Abstract Objective This study aimed to compare clinical features and overall survival (OS) between patients with primary peritoneal serous carcinoma (PPSC) and those with advanced serous ovarian carcinoma (ASOC) and to identify prognostic factors. Methods Patients diagnosed with PPSC and ASOC from 2010 to 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were enrolled. Pearson’s chi-square test was used to compare clinical features. The primary endpoint was OS. The Kaplan–Meier method and log–rank test were used to perform the survival analysis. Propensity score matching was also conducted. Univariate, multivariate and subgroup analyses were performed using the Cox proportional hazards model. Results A total of 708 PPSC patients and 7610 ASOC patients were enrolled. The clinical features of PPSC patients were noticeably different from those of ASOC patients. The survival analysis showed that PPSC patients had poorer outcomes than ASOC patients. Even after the clinical features were balanced, PPSC patients still had poorer survival. Univariate and multivariate analyses indicated that older age, higher tumor grade and advanced American Joint Committee on Cancer stage were adverse prognostic factors in both groups, while surgery and chemotherapy were protective factors. A subgroup analysis demonstrated that most factors favored ASOC patients. The total distant metastasis rates of PPSC and ASOC were similar. Liver or lung metastasis was common, but bone and brain metastases were rare. A higher proportion of liver metastasis was observed in the ASOC group. Conclusion The clinical features and survival outcomes between PPSC patients and ASOC patients are clearly different, and PPSC is more aggressive than ASOC. |
| first_indexed | 2024-04-11T02:00:14Z |
| format | Article |
| id | doaj.art-f804b79a38544efd9807b95dd04eda4e |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T02:00:14Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-f804b79a38544efd9807b95dd04eda4e2023-01-03T04:32:47ZengBMCJournal of Ovarian Research1757-22152021-02-0114111010.1186/s13048-021-00788-yDifferences between primary peritoneal serous carcinoma and advanced serous ovarian carcinoma: a study based on the SEER databaseXiaoduo Li0Qiao Yang1Mingjing Chen2Changqing Yang3Jianfen Gu4Qiang Dong5Guangrong Yang6Department of Obstetrics and Gynecology, Qijiang Maternal and Child Health HospitalDepartment of Ultrasound, The 941st Hospital of the PLA Joint Logistic Support ForceDepartment of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Oncology, Qijiang Hospital of the First Affiliated Hospital of Chongqing Medical UniversityDepartment of Nutrition, Qijiang Hospital of the First Affiliated Hospital of Chongqing Medical UniversityDepartment of General Medicine, Qijiang Hospital of the First Affiliated Hospital of Chongqing Medical UniversityDepartment of Oncology, Qijiang Hospital of the First Affiliated Hospital of Chongqing Medical UniversityAbstract Objective This study aimed to compare clinical features and overall survival (OS) between patients with primary peritoneal serous carcinoma (PPSC) and those with advanced serous ovarian carcinoma (ASOC) and to identify prognostic factors. Methods Patients diagnosed with PPSC and ASOC from 2010 to 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were enrolled. Pearson’s chi-square test was used to compare clinical features. The primary endpoint was OS. The Kaplan–Meier method and log–rank test were used to perform the survival analysis. Propensity score matching was also conducted. Univariate, multivariate and subgroup analyses were performed using the Cox proportional hazards model. Results A total of 708 PPSC patients and 7610 ASOC patients were enrolled. The clinical features of PPSC patients were noticeably different from those of ASOC patients. The survival analysis showed that PPSC patients had poorer outcomes than ASOC patients. Even after the clinical features were balanced, PPSC patients still had poorer survival. Univariate and multivariate analyses indicated that older age, higher tumor grade and advanced American Joint Committee on Cancer stage were adverse prognostic factors in both groups, while surgery and chemotherapy were protective factors. A subgroup analysis demonstrated that most factors favored ASOC patients. The total distant metastasis rates of PPSC and ASOC were similar. Liver or lung metastasis was common, but bone and brain metastases were rare. A higher proportion of liver metastasis was observed in the ASOC group. Conclusion The clinical features and survival outcomes between PPSC patients and ASOC patients are clearly different, and PPSC is more aggressive than ASOC.https://doi.org/10.1186/s13048-021-00788-yPrimary peritoneal serous carcinomaAdvanced serous ovarian carcinomaClinical featuresOverall survivalSEER |
| spellingShingle | Xiaoduo Li Qiao Yang Mingjing Chen Changqing Yang Jianfen Gu Qiang Dong Guangrong Yang Differences between primary peritoneal serous carcinoma and advanced serous ovarian carcinoma: a study based on the SEER database Journal of Ovarian Research Primary peritoneal serous carcinoma Advanced serous ovarian carcinoma Clinical features Overall survival SEER |
| title | Differences between primary peritoneal serous carcinoma and advanced serous ovarian carcinoma: a study based on the SEER database |
| title_full | Differences between primary peritoneal serous carcinoma and advanced serous ovarian carcinoma: a study based on the SEER database |
| title_fullStr | Differences between primary peritoneal serous carcinoma and advanced serous ovarian carcinoma: a study based on the SEER database |
| title_full_unstemmed | Differences between primary peritoneal serous carcinoma and advanced serous ovarian carcinoma: a study based on the SEER database |
| title_short | Differences between primary peritoneal serous carcinoma and advanced serous ovarian carcinoma: a study based on the SEER database |
| title_sort | differences between primary peritoneal serous carcinoma and advanced serous ovarian carcinoma a study based on the seer database |
| topic | Primary peritoneal serous carcinoma Advanced serous ovarian carcinoma Clinical features Overall survival SEER |
| url | https://doi.org/10.1186/s13048-021-00788-y |
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